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Links from GEO DataSets

Items: 20

1.
Full record GDS4874

IQGAP2 knockout model of hepatocellular carcinoma: time course

Analysis of liver from IQ-motif containing GTPase-activating protein 2 (IQGAP2) KOs at 6- and 24-months of age. IQGAP2 is a member of a multidomain scaffolding protein family that also includes IQGAP1 and IQGAP3. Results provide insight into a potential tumor suppressive role for IQGAP2 in liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE46646
12 Samples
Download data: CEL
2.

IQGAP2 knockout model of hepatocellular carcinoma

(Submitter supplied) Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4874
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE46646
ID:
200046646
3.

Expression data from mouse hepatocellular carcinomas developed in Axin1 hepatocyte deleted mice

(Submitter supplied) Mouse liver tumors (T) and non tumoral adjacent livers (NT) sorted from mice knock out for Axin1 gene specifically in the hepatocytes . 3 mice of the brother hood non deleted for Axin1 were used as controls (WT) We used microarrays to determine the differential expression between tumoral and non tumoral tissue.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL18802
16 Samples
Download data: CEL
Series
Accession:
GSE107374
ID:
200107374
4.

Niclosamide ethanolamine reverses gene expression and inhibits growth of hepatocellular carcinoma in vitro and in vivo

(Submitter supplied) Hepatocellular carcinoma (HCC) is a fatal malignancy with a dismal prognosis. The recent advances in genomics and transcriptomics have led to large volumes of molecular data for HCC, providing an unprecedented opportunity to translate these data into more effective therapeutics. By creating HCC gene expression signatures and comparing with drug response signatures from multiple datasets, we identified four antihelminthics (from over 1000 FDA-approved drugs) that can reverse the HCC disease gene expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
9 Samples
Download data: TXT
Series
Accession:
GSE77322
ID:
200077322
5.

Global analysis of genes regulated by canonical Wnt pathway

(Submitter supplied) Up-regulation of canonical Wnt signaling has been implicated in liver fibrosis and cancer. To determine canonical Wnt target genes potentially implicated in these diseases, we performed microarray analysis of culture-activated rat hepatic stellate cells (HSCs) treated with canonical Wnt inhibitors, DKK-1, ICG-001, or FJ9.
Organism:
Rattus norvegicus; Rattus norvegicus albus
Type:
Expression profiling by array
Platform:
GPL6247
6 Samples
Download data: CEL
Series
Accession:
GSE76330
ID:
200076330
6.

Study of gene expression of mouse cMET experiments

(Submitter supplied) We analyzed the molecular changes in a mouse c-MET over-expression model of hepatocellular carcinoma (HCC).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6794
49 Samples
Download data: CEL
Series
Accession:
GSE25142
ID:
200025142
7.

Study of gene expression of human liver Hepatocellular carcinoma

(Submitter supplied) Hepatocellular carcinoma (HCC) affects millions of people worldwide and is a lethal malignancy for which there are no effective therapies. To identify prognostic gene markers for liver cancer, we conducted transcriptome profiling of frozen tissues (tumor and non-tumor) from 300 early-to-advanced stage HCCs plus 40 cirrhotic and 6 normal livers.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10687
557 Samples
Download data: CEL
Series
Accession:
GSE25097
ID:
200025097
8.

An Immune Gene Expression Signature Associated With Development of Human Hepatocellular Carcinoma Identifies Mice That Respond to Chemopreventive Agents

(Submitter supplied) Background & Aims: Cirrhosis and chronic inflammation precede development of hepatocellular carcinoma (HCC) in approximately 80% of cases. We investigated immune-related gene expression patterns in liver tissues surrounding early-stage HCCs and chemopreventive agents that might alter these patterns to prevent liver tumorigenesis. Methods: We analyzed gene expression profiles of non-tumor liver tissues from 392 patients with early-stage HCC (training set, n=167 and validation set, n=225) and liver tissue from patients with cirrhosis without HCC (n=216, controls) to identify changes in expression of genes that regulate the immune response that could contribute to hepatocarcinogenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL21382
22 Samples
Download data: CEL
Series
Accession:
GSE125975
ID:
200125975
9.

DNA methylation-based prognosis and epidrivers in hepatocellular carcinoma

(Submitter supplied) Genome-wide expression analysis of 228 hepatocellular carcinoma and 168 cirrhotic samples as part of a integrated study of gene expression and DNA-methylation de-regulation in patients with hepatocellular carcinoma Analysis of whole-genome transcriptome changes in human samples from hepatocellular carcinoma patients
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13667
396 Samples
Download data: CEL
Series
Accession:
GSE63898
ID:
200063898
10.

Gene-expression profiles of hepatitis C-related, early-stage liver cirrhosis

(Submitter supplied) BACKGROUND & AIMS: Cirrhosis affects 1% to 2% of the world population and is the major risk factor for hepatocellular carcinoma (HCC). Hepatitis C cirrhosis-related HCC is the most rapidly increasing cause of cancer death in the United States. Noninvasive methods have been developed to identify patients with asymptomatic early-stage cirrhosis, increasing the burden of HCC surveillance, but biomarkers are needed to identify patients with cirrhosis who are most in need of surveillance. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8432
216 Samples
Download data: TXT
Series
Accession:
GSE15654
ID:
200015654
11.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
387 Samples
Download data: TXT
Series
Accession:
GSE10143
ID:
200010143
12.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Validation Set)

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
225 Samples
Download data: TXT
Series
Accession:
GSE10142
ID:
200010142
13.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, HCC)

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
80 Samples
Download data: TXT, XLS
Series
Accession:
GSE10141
ID:
200010141
14.

Gene Expression in Fixed Tissues and Outcome in Hepatocellular Carcinoma (Training Set, Liver)

(Submitter supplied) Background: It is a challenge to identify those patients who, after undergoing potentially curative treatments for hepatocellular carcinoma, are at greatest risk of recurrence. Such high-risk patients could receive novel interventional measures. An obstacle to the development of genome-based predictors of outcome in patients with hepatocellular carcinoma has been the lack of a means to carry out genomewide expression profiling of fixed, as opposed to frozen, tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
82 Samples
Download data: TXT
Series
Accession:
GSE10140
ID:
200010140
15.

Molecular mechanisms of liver carcinogenesis in the Mdr2-knockout mice

(Submitter supplied) Mouse models of hepatocellular carcinoma (HCC) simulate specific subgroups of human HCC. We investigated hepatocarcinogenesis in Mdr2-KO mice, a model of inflammation-associated HCC, using gene expression profiling and immunohistochemical analyses. Gene expression profiling demonstrated that although Mdr2-KO mice differ from other published murine HCC models, they share several important deregulated pathways and many coordinately differentially expressed genes with human HCC datasets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
15 Samples
Download data: CEL
Series
Accession:
GSE8642
ID:
200008642
16.

Argonaute CLIP defines a deregulated miR-122 bound transcriptome that correlates with patient survival in human liver cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other
Platforms:
GPL16791 GPL17021
46 Samples
Download data
Series
Accession:
GSE97061
ID:
200097061
17.

Argonaute CLIP defines a deregulated miR-122 bound transcriptome that correlates with patient survival in human liver cancer (Mouse RNA-Seq)

(Submitter supplied) MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Ago-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
9 Samples
Download data: TXT
Series
Accession:
GSE97060
ID:
200097060
18.

Argonaute CLIP defines a deregulated miR-122 bound transcriptome that correlates with patient survival in human liver cancer (Mouse CLIP-Seq)

(Submitter supplied) MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Ago-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL17021
9 Samples
Download data: TXT
19.

Argonaute CLIP defines a deregulated miR-122 bound transcriptome that correlates with patient survival in human liver cancer (Human CLIP-Seq)

(Submitter supplied) MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Ago-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL16791
28 Samples
Download data: TXT
20.

Gene expression data of human hepatocellular carcinoma (HCC)

(Submitter supplied) We used Affymetrix microarray profiling to analyze gene expression patterns in healthy donor liver as well as tumor and paired non-tumor tissue of HCC patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL3921 GPL571
488 Samples
Download data: CEL, TXT
Series
Accession:
GSE14520
ID:
200014520
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