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Links from GEO DataSets

Items: 20

1.
Full record GDS4874

IQGAP2 knockout model of hepatocellular carcinoma: time course

Analysis of liver from IQ-motif containing GTPase-activating protein 2 (IQGAP2) KOs at 6- and 24-months of age. IQGAP2 is a member of a multidomain scaffolding protein family that also includes IQGAP1 and IQGAP3. Results provide insight into a potential tumor suppressive role for IQGAP2 in liver.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE46646
12 Samples
Download data: CEL
2.

IQGAP2 knockout model of hepatocellular carcinoma

(Submitter supplied) Whole body knockout mice lacking IQ-motif containing GTPase-activating protein 2 (IQGAP2) develop spontaneous hepatocellular carcinoma (HCC) at the age of 12 months and older (Schmidt et al., 2008). Hepatic transcript expression profiles were obtained for IQGAP2 knockout and wild-type control mice of two age groups, 6- and 24-month-old. Liver samples from 24-month-old IQGAP2 knockout mice were HCC tumors, livers from all other groups were tumor-free. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4874
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE46646
ID:
200046646
3.

Study of gene expression of mouse cMET experiments

(Submitter supplied) We analyzed the molecular changes in a mouse c-MET over-expression model of hepatocellular carcinoma (HCC).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6794
49 Samples
Download data: CEL
Series
Accession:
GSE25142
ID:
200025142
4.

Study of gene expression of human liver Hepatocellular carcinoma

(Submitter supplied) Hepatocellular carcinoma (HCC) affects millions of people worldwide and is a lethal malignancy for which there are no effective therapies. To identify prognostic gene markers for liver cancer, we conducted transcriptome profiling of frozen tissues (tumor and non-tumor) from 300 early-to-advanced stage HCCs plus 40 cirrhotic and 6 normal livers.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10687
557 Samples
Download data: CEL
Series
Accession:
GSE25097
ID:
200025097
5.

Molecular mechanisms of liver carcinogenesis in the Mdr2-knockout mice

(Submitter supplied) Mouse models of hepatocellular carcinoma (HCC) simulate specific subgroups of human HCC. We investigated hepatocarcinogenesis in Mdr2-KO mice, a model of inflammation-associated HCC, using gene expression profiling and immunohistochemical analyses. Gene expression profiling demonstrated that although Mdr2-KO mice differ from other published murine HCC models, they share several important deregulated pathways and many coordinately differentially expressed genes with human HCC datasets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL339
15 Samples
Download data: CEL
Series
Accession:
GSE8642
ID:
200008642
6.

Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma (HT-HG_U133A)

(Submitter supplied) Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4269
Platform:
GPL3921
4 Samples
Download data: CEL
Series
Accession:
GSE10393
ID:
200010393
7.

Integrative Transcriptome Analysis Reveals Common Molecular Subtypes of Human Hepatocellular Carcinoma

(Submitter supplied) Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and prior attempts to develop genomic-based classification for HCC have yielded highly divergent results, indicating difficulty in identifying unified molecular anatomy. We performed a meta-analysis of gene expression profiles in data sets from eight independent patient cohorts across the world. In addition, aiming to establish the real world applicability of a classification system, we profiled 118 formalin-fixed, paraffin-embedded tissues from an additional patient cohort. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5474
118 Samples
Download data: TXT
Series
Accession:
GSE10186
ID:
200010186
8.
Full record GDS4269

Transforming growth factor-beta effect on Hepatocellular carcinoma Huh-7 cell line

Analysis of Hepatocellular carcinoma (HCC) Huh-7 cells stimulated with transforming growth factor-beta (TGF-β). HCC cell line Huh-7 has intact WNT pathway components. Results provide insight into the role of TGF-β in regulating WNT pathway activity in HCC cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL3921
Series:
GSE10393
4 Samples
Download data: CEL
9.

Met Expression Signature in Hepatocytes

(Submitter supplied) To identify HGF/Met regulated genes, we performed expression microarray analysis after inducible activation of Met receptor in primary cultures of hepatocytes established from wild-type control (Alb-Cre +/-) and Met conditional knockout mice (Alb-Cre +/-; Met Fl/Fl). Keywords: time series design
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3148
Platform:
GPL1536
60 Samples
Download data
Series
Accession:
GSE4451
ID:
200004451
10.
Full record GDS3148

Hepatocyte growth factor effect on Met receptor-knockout primary hepatocytes: time course

Analysis of Met-deficient hepatocytes treated with HGF for up to 24 hours. HGF/Met signaling controls invasive growth and metastasis in a variety of cancers, including hepatocellular carcinoma. Results identify a Met-dependent gene expression signature that may help elucidate the oncogenic process.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation, 5 time sets
Platform:
GPL1536
Series:
GSE4451
60 Samples
Download data
11.

Microarray profiling shows distinct differences between primary tumors and commonly used preclinical models in hepatocellular carcinoma

(Submitter supplied) Background: Despite advances in therapeutics, outcomes for hepatocellular carcinoma (HCC) remain poor and there is an urgent need for efficacious systemic therapy. Unfortunately, drugs that are successful in preclinical studies often fail in the clinical setting, and we hypothesize that this is due to functional differences between primary tumors and commonly used preclinical models. In this study, we attempt to answer this question by comparing tumor morphology and gene expression profiles between primary tumors, xenografts and HCC cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE72981
ID:
200072981
12.

Gene expression profile of human cancer associated hepatic stellate cells in HBV related hepatocellular carcinoma (HCC)

(Submitter supplied) We identified the genomic characteristics of peritumoral hepatic stellate cells (HSCs) in HBV related HCC. Expression levels of 17160 genes were compared between quiescent and activated HSCs and cancer associated myofibroblasts (CAMFs) from three independent samples per group. We find that among all significant changed genes (≥2-fold change and p<0.05), there were only 188 upregulated and 467 downregulated genes in peritumoral HSCs compared to intratumoral CAMFs. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
12 Samples
Download data: TXT
Series
Accession:
GSE124552
ID:
200124552
13.

Delineation of EZH2 oncogenic functions in hepatocellular carcinoma

(Submitter supplied) The goal of this study was to delineate the important EZH2 direct target genes that mediate the oncogenic properties of EZH2 in HCC. The EZH2 direct target genes in two HCC cell lines were identified by chromatin immunoprecipitation microarray (ChIP-chip) analysis and later confirmed by independent ChIP-PCR. The functions of the target genes were further examined.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL4125 GPL4124
8 Samples
Download data: TXT
Series
Accession:
GSE17733
ID:
200017733
14.

Transcriptomic characterization of Hepatocellular Carcinoma with CTNNB1 mutation

(Submitter supplied) we report transcritomic characterization of changes in CTNNB1 mutation positive HCCs in comparison to paratumoral tissues
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9115
8 Samples
Download data: TXT
Series
Accession:
GSE55048
ID:
200055048
15.

Aberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes

(Submitter supplied) MicroRNAs is a rapidly expanding area expected to change the way in which diseases will be diagnosed, treated and monitored in the future. Hepatocellular carcinoma (HCC) shows a rising incidence with high mortality but lack of effective targeted therapies. We identified the aberrantly expressed miRNAs involved in HCC through the comparison of miRNA expression profiling in cancerous hepatocytes with that in normal primary human hepatocytes and found 37 dysregulated miRNAs in HCC. more...
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8227
11 Samples
Download data: TXT
Series
Accession:
GSE20077
ID:
200020077
16.

Expression data of hepatocellular carcinoma and adjacent liver tissues

(Submitter supplied) To identify therapeutic targets with high specificity to HCC, we searched for genes significantly up-regulated in HCC over corresponding non-tumor liver using high-density microarrays Keywords: disease state analysis
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
20 Samples
Download data: CEL
Series
Accession:
GSE12941
ID:
200012941
17.

Transcriptomic analyses of Myc-induced zebrafish liver cancer

(Submitter supplied) To study the characteristics and mechanisms of Myc-induced zebrafish liver tumor, next-generation sequencing-based SAGE analyses were used to examine the transcriptomes of tumor and control samples. The results indicated that ribosome proteins were overwhelmingly up-regulated in the Myc-induced liver tumors. Cross-species analyses showed that the zebrafish Myc model correlated well with Myc transgenic mouse models for liver cancers. more...
Organism:
Danio rerio
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16034
8 Samples
Download data: TXT
Series
Accession:
GSE40745
ID:
200040745
18.

Transcriptomes of normal liver and spontaneous hepatocellular carcinoma in C3HeB/FeJ male mice

(Submitter supplied) The goal of this study was to identify and analyze differential gene expression between normal liver and tumor tissue responding or not to potential treatments. A second goal was to compare the mouse results with that from analysis of human differential gene expression for normal liver and hepatocellular carcinoma.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
14 Samples
Download data: CSV
Series
Accession:
GSE101818
ID:
200101818
19.

Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling

(Submitter supplied) Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed. We examined the expression profiles of 34 HCC specimens (17 hepatitis B virus [HBV]-related and 17 hepatitis C virus [HCV]-related) and 71 non-tumor liver specimens (36 chronic hepatitis B [CH-B] and 35 chronic hepatitis C [CH-C]) using an in-house cDNA microarray consisting of liver-predominant genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13536
105 Samples
Download data: GPR
Series
Accession:
GSE44074
ID:
200044074
20.

Astrocyte elevated gene-1 (AEG-1) promotes hepatocarcinogenesis: novel insights from a mouse model

(Submitter supplied) Astrocyte elevated gene-1 (AEG-1) as a positive inducer of hepatocellular carcinoma (HCC). Transgenic mice with hepatocyte-specific expression of AEG-1 were challenged with N-nitrosodiethylamine (DEN) and developed multinodular HCC with steatotic features. Thus, we have identified the follwoing AEG-1 functions: induction of steatosis, inhibition of senescence and activation of coagulation pathway to augment an aggressive hepatocarcinogenic phenotype.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE34669
ID:
200034669
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