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Links from GEO DataSets

Items: 20

1.
Full record GDS4875

Proliferator-activated receptor gamma agonist rosiglitazone effect on extravillous cytotrophoblasts in vitro

Analysis of EVCTs isolated from first trimester placenta and treated with rosiglitazone, a PPARγ agonist. EVCT invasion into the uterus is critical for placental and fetal development. Results provide insight into the molecular basis of PPARγ-mediated regulation of EVCT invasion in vitro.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL571
Series:
GSE28426
10 Samples
Download data: CEL
2.

Human villous cytotrophoblast: Rosiglitazone treated (RT-VCT) vs. Control (VCT)

(Submitter supplied) Trophoblasts, as the main part of placenta, undergo cell differentiation including invasion, migration, and fusion. Abnormalities in these processes can lead to a series of gestational diseases whose underlying mechanisms are still unclear. The peroxisome proliferator-activated receptor γ (PPARγ), expressed in the nuclei of extravillous trophoblasts (EVCTs) at the first trimester and villous cytotrophoblasts (VCTs) throughout the pregnancy, is proved to be essential in placentation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21609
5 Samples
Download data: GPR
Series
Accession:
GSE137434
ID:
200137434
3.

LOXs in invasive trophoblasts

(Submitter supplied) Human placental development is characterized by invasion of extravillous cytotrophoblasts (EVCTs) into the uterine wall during the first trimester of pregnancy. Peroxisome proliferator-activated receptor gamma (PPARG) plays a major role in placental development, and activation of PPARG by its agonists results in inhibition of EVCT invasion in vitro. To identify PPARG target genes, microarray analysis was performed using GeneChip technology on EVCT primary cultures obtained from first-trimester human placentas. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4875
Platform:
GPL571
10 Samples
Download data: CEL
Series
Accession:
GSE28426
ID:
200028426
4.

Gene expression profiling of trophoblast cells

(Submitter supplied) Invasion of cytotrophoblasts into uterine tissues is essential for placental development. To identify molecules regulating trophoblast invasion, mRNA signatures of purified villous (CTB, poor invasiveness) and extravillous (EVT, high invasiveness) trophoblasts isolated from first trimester human placentae and villous explant cultures, respectively, were compared using GeneChip analyses yielding 991 invasion/migration related transcripts. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3523
Platform:
GPL96
11 Samples
Download data: CEL, CHP
Series
Accession:
GSE9773
ID:
200009773
5.
Full record GDS3523

Non-migratory villous cytotrophoblasts and invasive extra-villous trophoblasts

Comparison of non-migratory villous cytotrophoblasts (CTBs) and invasive extra-villous trophoblasts. Invasion of CTBs into uterine tissues is essential for placental development. Results provide insight into the molecular mechanisms regulating trophoblast invasion.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 cell type sets
Platform:
GPL96
Series:
GSE9773
11 Samples
Download data: CEL, CHP
6.

Gene expression breast cancer

(Submitter supplied) Gene expression profiles were generated from 176 primary breast cancer patients and 10 normal breast samples. This data is used to investigate the clinial relevance of genes of interest from in vitro studies, including FABP5 and DDX1.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
186 Samples
Download data: TXT
Series
Accession:
GSE22820
ID:
200022820
7.

HIF-1 dependent gene expression upon S. aureus infection

(Submitter supplied) HIF-1 is an important transcription factor for immune responses to bacterial infection. We wanted to analyze the HIF-1 dependent gene expression upon S. aureus infection and analyzed the gene expression of HepG2 nt and HepG2 HIF-1-/- cells four hours upon infection using affymetrix human gene 1.0 st. gene arrays.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
12 Samples
Download data: CEL
Series
Accession:
GSE44943
ID:
200044943
8.

Placental PPARg-Regulated Genes

(Submitter supplied) Robust identification of placental PPARg target genes via mutliple PPARg-dependence criteria. Integration of differential expression data from Pparg-null, Rxra-null, Med1-nul and Ncoa6-null placentas and from WT and Pparg-null Trophoblast stem cells (TSC) differentiated for 2 or 4 days in the presence or absence of the PPARg agonist Rosiglitazone (Rosi).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
40 Samples
Download data: CEL
Series
Accession:
GSE39233
ID:
200039233
9.

Altered Placental transcriptome in first trimester affected by in vitro fertilization and embryo transfer (IVF-ET) treatments

(Submitter supplied) We used microarrays to detail the global gene expression in human placental tissues in first trimester from patients subject to in vitro fertilization and embryo transfer and normal pregnancy
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE122214
ID:
200122214
10.

Effect of Lithum on adult white matter

(Submitter supplied) Analysis of adult murine optic nerves cultured for 3 days in vitro (DIV) ex-vivo in organotypic media containing saline or Lithium Chloride. Results provide insight on the mechanism of action of Lithium on glial cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE132397
ID:
200132397
11.

Expression data from human Th1 and Th1Th17 cells

(Submitter supplied) We previously demonstrated that Th1Th17 cells are highly permissive to HIV-1, whereas Th1 cells are relatively resistant. Here, we investigated molecular mechanisms underlying these differences. Superior HIV replication in Th1Th17 vs. Th1 cells was regulated by entry and post-entry mechanisms. We used microarrays to detail the gene expression signatures caracterizing Th1 cells from Th1Th17.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE50175
ID:
200050175
12.

Transcriptomic signatures of villous cytotrophoblast and syncytiotrophoblast in term human placenta.

(Submitter supplied) During pregnancy, the placenta ensures multiple functions, which are directly involved in the initiation, fetal growth and outcome of gestation. The placental tissue involved in maternal-fetal exchanges and in synthesis of pregnancy hormones is the mononucleated villous cytotrophoblast (VCT) which aggregates and fuses to form and renew the syncytiotrophoblast (ST). Knowledge of the gene expression pattern specific to this endocrine and exchanges tissue of human placenta is of major importance to understand functions of this heterogeneous and complex tissue. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21609
11 Samples
Download data: TXT
Series
Accession:
GSE79333
ID:
200079333
13.

Acute Genome-Wide Effects of Rosiglitazone on PPARγ Transcriptional Networks in Adipocytes

(Submitter supplied) Here we report, for the first time, the acute effects of the synthetic PPARγ agonist rosiglitazone on the transcriptional network of PPARγ in adipocytes. Treatment with Rosiglitazone for 1 hour leads to acute transcriptional activation as well as repression of a number of genes as determined by genome-wide RNA polymerase II occupancy. Unlike what has been shown for many other nuclear receptors, agonist treatment does not lead to major changes in the occurrence of PPARγ binding sites. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11002
16 Samples
Download data: BIGWIG, TXT
Series
Accession:
GSE49423
ID:
200049423
14.

Isolation and Characterisation of a Novel Trophoblast Hoescht Side-Population with Stem Cell Properties from First Trimester Placentae

(Submitter supplied) In this work, we have isolated a Hoescht side-population of trophoblasts from first trimester human placentae that cluster separately from more differentiated trophoblast populations, and have a transcriptomic profile indicative of a stem cell population.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL15207
15 Samples
Download data: CEL
Series
Accession:
GSE57834
ID:
200057834
15.

Characterization of primary isolated villous CTB and proximal column EVT from first trimester human placenta.

(Submitter supplied) The goal of this study was to identify the gene expression signatures of two closely related types of trophoblast in human placentas: villous cytotrophoblasts (vCTB) and proximal column extravillous trophoblasts (pcEVT). The two populations were isolated from first trimester placentas and identified using the specific surface markers, EGFR (vCTB) and HLA-G (pcEVT).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
11 Samples
Download data: TXT
Series
Accession:
GSE80996
ID:
200080996
16.

Hypoxia directs human villous CTB differentiation towards the EVT lineage in a HIF-dependent manner.

(Submitter supplied) We showed that hypoxia directs first trimester primary villous cytotrophoblast (vCTB) differentiation preferentially towards HLAG+ extravillous trophoblast (EVT). Infection of primary vCTB with ARNT-specific shRNA attenuates this effect, suggesting a role of the intact HIF-complex in hypoxia-directed CTB differentiation into EVT.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: TXT
Series
Accession:
GSE80995
ID:
200080995
17.

Transcriptional Dynamics of Cultured Human Villous Cytotrophoblasts

(Submitter supplied) Transcriptomic characterization of cultured primary human cytrophoblasts (2nd trimester) undergoing differentiation/invasion in vitro.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE86171
ID:
200086171
18.

Transcriptomic Profiling of Trophoblast Subpopulations in Severe Preeclampsia Reveals Novel Aspects of RNA Dysregulation

(Submitter supplied) The maternal signs of preeclampsia, principally the new onset of high blood pressure, are thought to occur secondary to faulty placentation. Previous studies profiled the gene expression patterns of chorionic villi, the maternal-fetal interface or isolated cytotrophoblasts in this pregnancy complication. We theorized that transcriptomic analyses of trophoblast subpopulations in situ would give us new insights into the role of these cells in preeclampsia pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
23 Samples
Download data: CEL, TXT
Series
Accession:
GSE93839
ID:
200093839
19.

PPARg dependent expression changes during differentiation of 3T3L1 cell into adipocytes

(Submitter supplied) We profiled PPARg dependent gene expression changes during differntiation of 3T3L1 cell using PPARg siRNA 3T3-L1 (Pre-adipocyte) cell line was induced to differentiate using standard adipocyte differentiation media (IBMX, Dex and Insulin) 48hrs post-confluency. RNA was harvested at day -2 (confluent fibroblasts), 48hrs post-induction with IBMX, DEX and Insulin (day=0) and for each subsequent day after rosiglitazone treatment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
48 Samples
Download data: TXT
Series
Accession:
GSE12929
ID:
200012929
20.

Evolved Labels of Placental Invasion in Human and Bovine Endometrial Stroma

(Submitter supplied) Among mammals, the extent of placental invasion is correlated with vulnerability to malignancy. Animals with more invasive placentation (e.g. humans) are more vulnerable to malignancy, whereas animals with a non-invasive placenta (e.g. ruminants) are less likely to develop malignant cancer. To explain this correlation,we propose the hypothesis of Evolved Levels ofInvasibility (ELI) positing that the permissiveness of stromal tissue to invasion is a unitary character affecting both placental and cancer invasion. more...
Organism:
Homo sapiens; Bos taurus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL19172 GPL16791
12 Samples
Download data: XLSX
Series
Accession:
GSE136299
ID:
200136299
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