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Items: 4

1.
Full record GDS4880

Treatment-naive, chronic hepatitis C virus-infected patients: CD4+ and CD8+ T-lymphocytes

Analysis of antigen-specific CD4+ and CD8+ T-cells from treatment-naive, chronic hepatitis C virus (CHC) patients with high or low viral loads. Results provide insight into molecular mechanisms underlying functional impairment differences between CD4+ and CD8+ T-cells during CHC infection.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 cell type, 3 disease state sets
Platform:
GPL570
Series:
GSE49954
30 Samples
Download data: CEL
2.

T lymphocytes from Chronic HCV-infected patients express unique pro-apoptotic gene signature.

(Submitter supplied) Although extensive studies have demonstrated the gene expression patterns of antigen-specific CD4+ and CD8+ T-cells during chronic hepatitis C virus (HCV) infection, the transcriptional profiles of global CD4+ and CD8+ T-cells remains unclear. In this report, we recruited 10 long-term (~20 years) treatment-naïve chronic HCV (CHC) patients and 5 healthy donors (HDs) to investigate differences in global CD4+ and CD8+ T-cells gene expression profile. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4880
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE49954
ID:
200049954
3.

Comparison of gene expression profiles of HCV-specific CD8 T cells from resolving patients and HCV-specific CD8 T cells chronic patients that target conserved or escaped epitopes.

(Submitter supplied) T cell exhaustion is a well-defined process diminishing the efficacy of the CD8 response in persistent viremia. What is less understood is whether early differences in T cell regulation already predetermine the fate of the T cell response and infection outcome. Its dichotomous outcome that is unique among human viral infections makes hepatitis C virus infection uniquely suited to compare transcriptional regulation between HCV-specific CD8 T cells that do and do not achieve viral control. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL22932
78 Samples
Download data: CEL
Series
Accession:
GSE93712
ID:
200093712
4.

Comparison of gene expression profiles of HCV-specific CD8 T cells from resolving and chronic patients.

(Submitter supplied) T cell exhaustion is a well-defined process diminishing the efficacy of the CD8 response in persistent viremia. What is less understood is whether early differences in T cell regulation already predetermine the fate of the T cell response and infection outcome. Its dichotomous outcome that is unique among human viral infections makes hepatitis C virus infection uniquely suited to compare transcriptional regulation between HCV-specific CD8 T cells that do and do not achieve viral control. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL22931
10 Samples
Download data: CEL
Series
Accession:
GSE93711
ID:
200093711
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