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Links from GEO DataSets

Items: 20

1.
Full record GDS4885

Kruppel-like zinc finger protein ZNF217 overexpression effect on breast cancer cell line

Analysis of MDA-MB-231 cells overexpressing ZNF217. ZNF217 is a Kruppel-like zinc finger protein that localizes to the nucleus. Results provide insight into the role of ZNF217 in the progression of breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE35511
4 Samples
Download data: CEL
DataSet
Accession:
GDS4885
ID:
4885
2.

Gene-expression profiling of ZNF217-overexpressing MDA-MB-231 cells

(Submitter supplied) To obtain an overview of the cellular functions regulated by ZNF217 signaling in breast-cancer cell lines, we performed global gene-expression profiling on MDA-MB-231-pcDNA6 and MDA-MB-231-ZNF217 cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4885
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE35511
ID:
200035511
3.

The transcription factor ZNF217 is a prognostic biomarker and therapeutic target during breast cancer progression

(Submitter supplied) The transcription factor ZNF217 is a candidate oncogene in the amplicon on chromosome 20q13 that occurs in 20-30% of primary human breast cancers and that correlates with poor prognosis. We show Znf217 overexpression drives aberrant differentiation and signaling events, promotes increased self-renewal capacity, mesenchymal marker expression, motility and metastasis, and represses an adult tissue stem cell gene signature downregulated in cancers. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11062
8 Samples
Download data: TXT
Series
Accession:
GSE24727
ID:
200024727
4.

lncRNA-Activated by TBGF-β-induced transcriptional changes and binding targets in hepatocellular carcinoma cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array; Other
Platforms:
GPL16951 GPL15314 GPL11154
14 Samples
Download data: GPR, TXT
Series
Accession:
GSE54800
ID:
200054800
5.

Genome-wide identification of transcripts associated with lncRNA-ATB by RIP-seq

(Submitter supplied) The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL11154
2 Samples
Download data: TXT
Series
Accession:
GSE54799
ID:
200054799
6.

Expression profiling of SMMC-7721 cells: stably express lncRNA-ATB vs pcDNA3.1

(Submitter supplied) lncRNA-ATB induced transcriptional changes in SMMC-7721
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16951
6 Samples
Download data: GPR
Series
Accession:
GSE54798
ID:
200054798
7.

Long non-coding RNAs and mRNAs regulated by TGF-β

(Submitter supplied) The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB promotes the invasion-metastasis cascade, which suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for anti-metastatic therapies.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platform:
GPL15314
6 Samples
Download data: TXT
Series
Accession:
GSE54797
ID:
200054797
8.

Expression data from Control and Six1 expressing MCF7 cells

(Submitter supplied) Inappropriate activation of developmental pathways is a well-recognized tumor-promoting mechanism. Here we show that overexpression of the homeoprotein Six1, normally a developmentally restricted transcriptional regulator, increases Transforming Growth Factor-beta (TGF-beta) signaling in mammary carcinoma cells and induces an epithelial to mesenchymal transition (EMT) that is in part dependent on its ability to increase TGF-beta signaling. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3921
20 Samples
Download data: CEL
Series
Accession:
GSE23655
ID:
200023655
9.

YWHAZ is an Invasion and Metastasis promoting genes of Lung cancer

(Submitter supplied) Metastasis is a major cause leading to mortality for lung cancer patients. We identified YWHAZ as a potential metastasis-promoting candidate and found that overexpression of YWHAZ promotes lung cancer cell proliferation, anchorage-independent growth, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. It not only increases cell protrusions and branchings but also induces epithelial-mesenchymal transition. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE20318
ID:
200020318
10.

SIRT7 Antagonizes TGF-β Signaling and Inhibits Breast Cancer Metastasis

(Submitter supplied) Protein deacetylase SIRT7 is significantly downregulated in lung metastases of human patient and mouse tissues, and predicted metastasis-free survival. To explore the roles of SIRT7 in breast cancer, we analysed the gene expressions in breast cancer BT549 cells with SIRT7 knockdown or not.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
6 Samples
Download data: XLSX
Series
Accession:
GSE99596
ID:
200099596
11.

Mesenchymal cancer cell-stromal crosstalk promotes niche activation, epithelial reversion and metastatic colonization

(Submitter supplied) The experiment was design to address the intrinsic differences between metastatic cancer stem cells in the primary tumour and during metastatic colonization in the mouse mammary gland tumour model MMTV-pyMT.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
3 Samples
Download data: TXT
Series
Accession:
GSE63558
ID:
200063558
12.

14-3-3ζ promotes TGF-β-induced bone metastasis program in 231 cells

(Submitter supplied) To explore the regulatory role of 14-3-3ζ in TGF-β induced bone metastasis program in 231 cells, we generated MDA-MB-231 human breast cancer cell sublines with 14-3-3ζ shRNA knockdown (231.ZKD-4 and 231.ZKD-5) and scrambled shRNA (231.Scr) We performed cDNA microarray analysis on these cells treated with vehicle or TGF-β (5ng/ml, 2 hours) respectively in vitro
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10904
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE52066
ID:
200052066
13.

14-3-3ζ overexpression-induced gene signature in MCF-10A cells

(Submitter supplied) To study the function of 14-3-3ζ, we established MCF-10A human mammary epithelial cells transduced with 14-3-3ζ (10A.ζ) and vector (10A.Vec) We performed gene expression profiling on 10A.ζ cells and 10A.Vec cells, and normalized to profiling of MCF-10A parental cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
3 Samples
Download data: CEL, TXT
Series
Accession:
GSE52032
ID:
200052032
14.

Metastases of breast cancer

(Submitter supplied) Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL96
65 Samples
Download data: CEL
Series
Accession:
GSE14020
ID:
200014020
15.

Metastases of breast cancer (U133A)

(Submitter supplied) Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. Keywords: Disease state analyses
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
36 Samples
Download data: CEL
Series
Accession:
GSE14018
ID:
200014018
16.

Metastases of breast cancer (U133plus2)

(Submitter supplied) Comparisons among breast cancer metastases at different organs revealed distinct microenvironments as characterized by cytokine content. Such microenvironment distinction might be important to dictate how the cancer cells adapt to survival before they successfully colonize. Keywords: Disease state analyses
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE14017
ID:
200014017
17.

Genes Directly Regulated by the Oncogene ZNF217 Using ChIP-chip Assays on ENCODE and Promoter Arrays and Expression Data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by genome tiling array
4 related Platforms
43 Samples
Download data: TXT
18.

Identification of genes directly regulated by the oncogene ZNF217 using ChIP-chip assays (Expression Data)

(Submitter supplied) It has been proposed that ZNF217, which is amplified at 20q13 in various tumors, plays a key role during neoplastic transformation. ZNF217 has been purified in complexes that contain repressor proteins such as CtBP2, suggesting that it acts as a transcriptional repressor. However, the function of ZNF217 has not been well characterized due to a lack of known target genes. Using a global ChIP-chip approach, we have identified thousands of ZNF217 binding sites in three tumor cell lines (MCF7, SW480, and Ntera2). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2507
6 Samples
Download data
19.

Identification of genes directly regulated by the oncogene ZNF217 using ChIP-chip assays (Promoter Arrays)

(Submitter supplied) It has been proposed that ZNF217, which is amplified at 20q13 in various tumors, plays a key role during neoplastic transformation. ZNF217 has been purified in complexes that contain repressor proteins such as CtBP2, suggesting that it acts as a transcriptional repressor. However, the function of ZNF217 has not been well characterized due to a lack of known target genes. Using a global ChIP-chip approach, we have identified thousands of ZNF217 binding sites in three tumor cell lines (MCF7, SW480, and Ntera2). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL3930 GPL4704
26 Samples
Download data: TXT
20.

Identification of genes directly regulated by the oncogene ZNF217 using ChIP-chip assays

(Submitter supplied) It has been proposed that ZNF217, which is amplified at 20q13 in various tumors, plays a key role during neoplastic transformation. ZNF217 has been purified in complexes that contain repressor proteins such as CtBP2, suggesting that it acts as a transcriptional repressor. However, the function of ZNF217 has not been well characterized due to a lack of known target genes. Using a global ChIP-chip approach, we have identified thousands of ZNF217 binding sites in three tumor cell lines (MCF7, SW480, and Ntera2). more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL3980
11 Samples
Download data: TXT
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