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Links from GEO DataSets

Items: 6

1.
Full record GDS4892

Age effect on skeletal muscle precursor cells

Analysis of FACS-sorted CD45-Ter119-Sca-1-CD29+Cxcr4+ skeletal muscle precursor (SMP) cells from young, middle-aged, and old C57BL/6 males. Results provide insight into the molecular mechanisms underlying age-related skeletal muscle and stem cell dysfunction.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 age sets
Platform:
GPL1261
Series:
GSE50821
14 Samples
Download data: CEL
2.

Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle

(Submitter supplied) In this study, we investigated signaling pathways in Skeletal muscle precursors that are altered with aging and age-related deficits in muscle regenerative potential. We performed fluorescence activated cell sorting (FACS) to obtain highly purified skeletal muscle satellite cells from young, middle-aged and old mice. Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral "rejuvenating" factors that can restore regenerative function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4892
Platform:
GPL1261
14 Samples
Download data: CEL
Series
Accession:
GSE50821
ID:
200050821
3.

GDF11 is a myokine that inhibits muscle differentiation and induces atrophy during regeneration

(Submitter supplied) Age-related frailty may in part be due to a decreased competency in skeletal muscle regeneration. The role of the closely related TGFbeta amily molecules myostatin and GDF11 in regeneration is unclear. The commercially available antibody which in a prior report was used to demonstrate an age-related decrease in GDF11 was found to detect both GDF11 and myostatin, and with this reagent it appears that the combination of GDF11 and myostatin increases with age in serum. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
56 Samples
Download data: CEL
Series
Accession:
GSE67326
ID:
200067326
4.

miR-431 promotes differentiation and regeneration of old skeletal muscle by targeting Smad4

(Submitter supplied) we identified novel age-related microRNAs through comparative analysis of miRNA expression profiles in young and old myoblasts using next generation sequencing (NGS)
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11002
8 Samples
Download data: TXT
Series
Accession:
GSE66267
ID:
200066267
5.

Transcriptional profiles of skeletal muscle stem cells from mice of different ages, exercise status, and Ccnd1 genotypes

(Submitter supplied) Voluntary exercise enhances old skeletal muscle stem cell (MuSC) function in vivo and ex vivo, dependent on upregulation of Ccnd1. To determine the transcriptional changes associated with these phenotypes, RNA-Seq was performed on MuSCs from young and old mice that had exercised or not exercised, and from young mice with MuSC-specific loss-of-function deletions in zero, one, or both alleles of Ccnd1.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
36 Samples
Download data: TXT
Series
Accession:
GSE77178
ID:
200077178
6.

Effect of GDF11 on RANKL-induced osteoclastogenesis

(Submitter supplied) GDF11 treatment leads to bone loss in mice and strongly stimulates RANKL-induced osteoclastogenesis of bone marrow–derived macrophages (BMMs) in vitro. We used microarrays to identified distinct classes of up-regulated genes in BMMs after GDF11 treatment.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE84609
ID:
200084609
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