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Links from GEO DataSets

Items: 3

1.
Full record GDS4895

SIRT1 deficiency effect on the brain

Analysis of brains deficient for SIRT1. SIRT1 is an NAD-dependent protein deacetylase that play a role in numerous metabolic processes in many tissues, including the brain. Results provide insight into the impact of SIRT1 on brain physiology.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE28790
8 Samples
Download data: CEL
2.

SIRT1 impact on global gene expression in the brain

(Submitter supplied) We compared expression of genes in brains of SIRT1 brain-specific knockouts (BSKO) to those of wild-type littermate controls (WT).
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4895
Platform:
GPL8321
8 Samples
Download data: CEL
Series
Accession:
GSE28790
ID:
200028790
3.

The role of SIRT1 in regulation of transcription and splicing in mouse embryonic stem cells

(Submitter supplied) SIRT1 is a nuclear enzyme that removes acetyl-groups from target proteins by using NAD+ as a co-substrate. SIRT1 regulates many vital biological processes such as metabolism, stress response, development, and aging. We have previously shown that SIRT1 is critically involved in mouse embryonic stem cell (mESC) maintenance and differentiation in part through modulation of the acetylation status of key transcription factors and their mediated amino acid metabolism and cell signaling. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
6 Samples
Download data: XLSX
Series
Accession:
GSE163920
ID:
200163920
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