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Links from GEO DataSets

Items: 20

1.
Full record GDS4897

Skeletal muscle of patients with inherited insulin resistance

Analysis of muscle from patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR). This mutation is associated with inherited insulin resistance. Results provide insight into molecular mechanisms underlying insulin resistance in skeletal muscle.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL571
Series:
GSE36297
16 Samples
Download data: CEL
DataSet
Accession:
GDS4897
ID:
4897
2.

A PGC-1alpha-dependent decrease in mitochondrial oxidative metabolism in muscle of humans with inherited insulin resistance

(Submitter supplied) We used microarrays to assess gene expression profiling of 6 patients with a mutation (Arg1174Gln) in the tyrosine kinase domain of the insulin receptor gene (INSR) and 10 matched healthy controls
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4897
Platform:
GPL571
16 Samples
Download data: CEL
Series
Accession:
GSE36297
ID:
200036297
3.

Reduced expression of mitochondrial oxidative metabolism genes in skeletal muscle of women with PCOS

(Submitter supplied) Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin resistance in the polycystic ovary syndrome (PCOS). Using the HG-U133 Plus 2.0 expression array from Affymetrix, we analyzed gene expression in skeletal muscle from obese women with PCOS (n=16) and age- and body mass index-matched control women (n=13) metabolically characterized by euglycemic-hyperinsulinemic clamp and indirect calorimetry. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3104
Platform:
GPL570
29 Samples
Download data: CEL
Series
Accession:
GSE6798
ID:
200006798
4.
Full record GDS3104

Insulin-resistant polycystic ovary syndrome: muscle

Analysis of vastus lateralis muscles from women with insulin-resistant polycystic ovary syndrome (PCOS). Insulin resistance in skeletal muscles is a risk factor for the development of type 2 diabetes in women with PCOS. Results provide insight into the pathogenesis of insulin resistance in PCOS.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state sets
Platform:
GPL570
Series:
GSE6798
29 Samples
Download data: CEL
DataSet
Accession:
GDS3104
ID:
3104
5.

Progressive loss of PGC-1alpha expression in aging muscle potentiates glucose intolerance and systemic inflammation

(Submitter supplied) Decreased mitochondrial mass and function in muscle of diabetic patients is associated with low PGC-1alpha, a transcriptional coactivator of the mitochondrial gene program. To investigate whether reduced PGC-1alpha and oxidative capacity in muscle directly contributes to age-related glucose intolerance, we compared the genetic signatures and metabolic profiles of aging mice lacking muscle PGC-1alpha. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4904
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE52550
ID:
200052550
6.
Full record GDS4904

Peroxisome proliferator-γ coactivator-1α deficiency effect on aged gastrocnemius muscle

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE52550
12 Samples
Download data: CEL
7.

Effects of a 8-week training on human skeletal muscle

(Submitter supplied) Context: Exercise training is a plausible model for identification of molecular mechanisms that cause metabolic-related changes in human skeletal muscle. Objective: The goal was to explore the molecular basis of the adaptation of skeletal muscle to exercise training. Design and Intervention: Obese male subjects were subjected to an individualized supervised training program targeted in order to optimize lipid oxidation during 8 weeks. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16022
16 Samples
Download data: GPR
Series
Accession:
GSE40551
ID:
200040551
8.

Transcription profiling of myotubes from patients with type 2 diabetes

(Submitter supplied) Microarray-based studies of skeletal muscle from patients with type 2 diabetes and high-risk individuals have demonstrated that insulin resistance and reduced mitochondrial biogenesis co-exist early in the pathogenesis of type 2 diabetes independent of hyperglycaemia and obesity. It is unknown whether reduced mitochondrial biogenesis or other transcriptional alterations co-exist with impaired insulin-responsiveness in primary human muscle cells from patients with type 2 diabetes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3681
Platform:
GPL8300
20 Samples
Download data: CEL
Series
Accession:
GSE12643
ID:
200012643
9.
Full record GDS3681

Type 2 diabetes: myotube

Analysis of myotube cell lines established from type 2 diabetes (T2D) subjects. Insulin resistance and reduced mitochondrial biogenesis coexist early in T2D pathogenesis independent of hyperglycemia and obesity. Results provide insight into the effect of T2D on developing skeletal muscle cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL8300
Series:
GSE12643
20 Samples
Download data: CEL
DataSet
Accession:
GDS3681
ID:
3681
10.

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles

(Submitter supplied) Transcriptional microarray analysis was conducted on gastrocnemius muscle of control and PGC-1β(i)skm-/- mice one week after the last tamoxifen administration using the Affymetrix Mouse Gene 1.0 ST.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE73572
ID:
200073572
11.

mTOR pathway controls mitochondrial gene expression and respiration through the YY1/PGC-1alpha transcriptional complex

(Submitter supplied) Mitochondrial oxidative function is tightly controlled to maintain energy homeostasis in response to nutrient and hormonal signals. An important cellular component in the energy sensing response is the target of rapamycin (TOR) kinase pathway; however whether and how mTOR controls mitochondrial oxidative activity is unknown. Here, we show that mTOR kinase activity stimulates mitochondrial gene expression and oxidative function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE5332
ID:
200005332
12.

Analysis of PGC-1alpha overexpression effects on the whole transcriptome in cultured skeletal muscle cells

(Submitter supplied) The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) is a chief activator of the mitochondrial and metatolic program in skeletal muscle (skm) and prevents atrophy. Here we tested whether PGC-1α overexpression could restructure the transcriptome and metabolism of cultured human skeletal myotubes, which display an athropic phenotype. An oligonucleotide microarray analysis was used to reveal PGC-1α effects on the whole transcriptome, and the possible impact on fuel metabolism reprogramming was examined. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
6 Samples
Download data: TXT
Series
Accession:
GSE28206
ID:
200028206
13.

Gene expression from Prep1-ablated mice

(Submitter supplied) The homeodomain transcription factor Prep1 was previously shown to regulate insulin sensitivity. Our aim was to study the specific role of Prep1 for the regulation of energy metabolism in skeletal muscle. Muscle specific ablation of Prep1 resulted in increased expression of respiratory chain subunits. This finding was consistent with an increase in mitochondrial enzyme activity without affecting mitochondrial volume fraction as assessed by electron microscopy. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
8 Samples
Download data: TXT
Series
Accession:
GSE52424
ID:
200052424
14.

Hypomorphic Mutation in PGC1beta causes mitochondrial dysfunction and liver insulin resistance

(Submitter supplied) PGC1beta is a transcriptional coactivator that potently stimulates mitochondrial biogenesis and respiration of cells. Here, we have generated mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice). These mice express a mutant protein that has reduced coactivation activity on a subset of transcription factors, including ERRalpha, a major target of PGC1beta in the induction of mitochondrial gene expression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS2515 GDS3197
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE6210
ID:
200006210
15.
Full record GDS3197

Transcriptional coactivator PGC-1beta hypomorphic mutation effect on the liver

Analysis of livers of animals bearing a hypomorphic PGC-1beta mutation. PGC-1beta is a transcriptional coactivator that stimulates mitochondrial biogenesis and respiration of cells. Results provide insight into the function of PGC-1beta in the liver.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE6210
6 Samples
Download data: CEL
16.
Full record GDS2515

Transcriptional coactivator PGC-1beta hypomorphic mutation effect on the skeletal muscle

Analysis of quadriceps muscles of animals bearing a hypomorphic PGC-1beta mutation. PGC-1beta is a transcriptional coactivator that stimulates mitochondrial biogenesis and respiration of cells. Results provide insight into the function of PGC-1beta in the skeletal muscle.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE6210
6 Samples
Download data: CEL
17.

Control of oxidative stress by miRNA and impact on ovarian tumorigenesis

(Submitter supplied) Transcriptome analysis of high-grade human ovarian adenocarcinomas. The hypothesis tested in the present study was that two reciprocal pathways, namely oxidative stress response and fibrosis, enable to build a hierarchical cluster of ovarian patients.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
107 Samples
Download data: CEL
Series
Accession:
GSE26193
ID:
200026193
18.

TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle

(Submitter supplied) substantial number of people at risk to develop type 2 diabetes could not improve insulin sensitivity by physical training intervention. We studied the mechanisms of this impaired exercise response in 20 middle-aged individuals who performed a controlled eight weeks cycling and walking training at 80 % individual VO2max. Participants identified as non-responders in insulin sensitivity (based on Matsuda index) did not differ in pre-intervention parameters compared to high responders. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
36 Samples
Download data: CEL
Series
Accession:
GSE72462
ID:
200072462
19.

Role of p110a subunit of PI3-kinase in skeletal muscle mitochondria

(Submitter supplied) Skeletal muscle insulin resistance, decreased phosphatidylinositol 3-kinase (PI3K) activation and altered mitochondrial function are hallmarks of type 2 diabetes. We created mice with a muscle-specific knockout of p110α or p110β, the two major catalytic subunits of PI3K. We find that mice with muscle-specific knockout of p110α, but not p110β, display impaired muscle insulin signaling and reduced muscle size due to enhanced proteasomal and autophagic activity. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
29 Samples
Download data: CSV
Series
Accession:
GSE124394
ID:
200124394
20.

The Mitochondrial Calcium Uniporter controls skeletal muscle mass in vivo

(Submitter supplied) Muscle atrophy contributes to the poor prognosis of many physiopathological conditions, but pharmacological therapies are still limited. Muscle activity leads to major swings in mitochondrial [Ca2+] which control aerobic metabolism, cell death and survival pathways. We have investigated in vivo the effects of mitochondrial Ca2+ homeostasis in skeletal muscle function and trophism, by overexpressing or silencing the Mitochondrial Calcium Uniporter (MCU). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL13912
30 Samples
Download data: TXT
Series
Accession:
GSE60931
ID:
200060931
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