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Links from GEO DataSets

Items: 13

1.
Full record GDS4902

FIZZ2 deficient lung response to the fibrotic agent bleomycin

Analysis of lungs of FIZZ2 deficient mutants following endotracheal injection of bleomycin to induce pulmonary fibrosis. Results provide insight into the role of FIZZ2 in the pathogenesis of fibrotic lung dieseases.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE25640
12 Samples
Download data: CEL
2.

Expression data from wild type or FIZZ2 knockout murine lungs

(Submitter supplied) To study the possible fibrotic role of FIZZ2, bleomycin was used to induce pulmonary fibrosis in wild type and FIZZZ2 knockout mice, lungs were then harvested and processed for RNA isolation. We used microarrays to detail the global gene expression regulated by FIZZ2 during fibrotic process.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4902
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE25640
ID:
200025640
3.

Expression data from mouse lung epithelium after allergen challenge

(Submitter supplied) Changes occur in the lung epithelium after allergen challenge that may give insight into asthma pathogenesis and we sought to identify novelepithelial genes induced by allergen exposure. We used microarrays to identify up-regulated genes induced by allergen challenge in lung epithelium.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4423
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE34764
ID:
200034764
4.
Full record GDS4423

Lung epithelium response to fungal allergen Alternaria

Analysis of bronchial brushings of lung epithelium from C57BL/6 females after Alternaria challenge. Alternaria allergen is associated with severe asthma, including life-threatening exacerbations. Results provide insight into the molecular basis of the acute innate airway response to Alternaria.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 stress sets
Platform:
GPL6246
Series:
GSE34764
6 Samples
Download data: CEL, CHP
5.

MMP1 and MMP7 as potential peripheral blood biomarkers in Idiopathic Pulmonary Fibrosis

(Submitter supplied) Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with significant morbidity and mortality. We identified a combinatorial signature of 5 proteins that was sufficient to distinguish IPF patients from controls; of these proteins MMP7 and MMP1 exhibited significantly higher values in both peripheral blood concentrations and lung tissue gene expression, suggesting their role as true biomarkers. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
46 Samples
Download data: TXT
Series
Accession:
GSE10667
ID:
200010667
6.

Gene expression analysis of lung fibroblasts in bleomycin-induced pulmonary fibrosis

(Submitter supplied) We conducted fibroblast-specific transcriptome analysis by next generation sequencing in order to investigate qualitative change and activation signatures of lung fibroblasts in bleomycin-induced pulmonary fibrosis. Lung fibroblasts were identified by using reporter mice of collagen-α2(I), in which collagen I-producing fibroblasts were labeled with EGFP. Lungs were dissociated with protease sollution, and single cell suspension were stained with lineage markers (Ter119, CD45, CD31, EpCAM). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16331
2 Samples
Download data: TXT
Series
Accession:
GSE42564
ID:
200042564
7.

miRNA in human lung fibroblasts

(Submitter supplied) By employing miRCURY™ LNA array, we have identified a subset (79) of the total number of miRNAs that are differentially expressed in TGF beta1-treated human lung fibroblasts MRC-5 cells, as compared to untreated control cells
Organism:
Mus musculus; Human alphaherpesvirus 1; Human alphaherpesvirus 2; Human gammaherpesvirus 4; Rattus norvegicus; JC polyomavirus; Human immunodeficiency virus 1; Merkel cell polyomavirus; Human gammaherpesvirus 8; Mus musculus cytomegalovirus 2; Human polyomavirus 1; Macaca mulatta polyomavirus 1; Homo sapiens; Human betaherpesvirus 5; Murid gammaherpesvirus 4
Type:
Non-coding RNA profiling by array
Platform:
GPL11432
9 Samples
Download data: TXT
Series
Accession:
GSE43992
ID:
200043992
8.

Development of gene expression signatures for Mmp19 regulation of fibroblast phenotype in mouse lungs

(Submitter supplied) We have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish Mmp19 regulation of fibroblast phenotype changes in mouse lungs. Pulmonary fibrosis was induced by bleomycin at 0.08 u in 50ul of saline. At 21st day the mice were sacrificed and mouse lung fibroblasts were isolated and cultured in FBM plus additives following Lonza's portocol. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
6 Samples
Download data: TXT
Series
Accession:
GSE49643
ID:
200049643
9.

RELMa induced differential gene expression in CD11c+ cells

(Submitter supplied) Mouse lung CD11c+ cell gene expression changes following recombinant RELMa treatment
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL25266
12 Samples
Download data: RCC, TXT
Series
Accession:
GSE116552
ID:
200116552
10.

Single Cell Analysis of Pulmonary Fibrotic Mesenchymal Cells Indicates a New Subtype

(Submitter supplied) Stromal taxonomy consists of multiple cell subtypes that play a critical role in tissue repair or regeneration, fibrosis, inflammation, angiogenesis and tumor formation. However, their identities are not fully understood, as these conventional classified populations have historically been defined by restricted sets of markers. We performed single-cell RNA sequencing to investigate stromal mesenchymal cells (MCs) in normal and fibrotic mouse lung. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
6 Samples
Download data: CSV, XLSX
Series
Accession:
GSE104154
ID:
200104154
11.

Single cell RNA-sequencing of normal and fibrotic lungs in mouse and human

(Submitter supplied) We performed scRNA-seq of cells obtained with a protocol designed to capture all of the collagen-producing cells from normal and fibrotic mouse and human lungs.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL21103 GPL24676
24 Samples
Download data: MTX, TSV
Series
Accession:
GSE132771
ID:
200132771
12.

Expression data from mice lung CD45-negative cells during fibrosis development

(Submitter supplied) We used microarrays to detail the global gene expression change and identified distinct classes of up-regulated genes during fibrosis development in lung non-hematopoietic cells. Close interaction between nonhematopoietic and hematopoietic cells are critical for fibrosis development.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL20775
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE143931
ID:
200143931
13.

Resistin-like molecule α provides vitamin A-dependent antimicrobial protection of the skin

(Submitter supplied) The skin is the human body’s largest organ and is in contact with a diverse community of microorganisms that includes both resident and pathogenic bacteria. Skin immune defenses include the production of antimicrobial proteins that kill bacteria directly. However, we still have an incomplete understanding of how skin antimicrobial proteins promote homeostasis with resident bacterial communities and limit infection. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
14 Samples
Download data: TXT
Series
Accession:
GSE108718
ID:
200108718
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