Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS4903

Rheumatoid arthritic synovium response to rituximab

Analysis of synovial biopsy samples from anti-TNF resistant rheumatoid arthritis (RA) patients 12 wks after the start of rituximab (RTX) therapy. RTX is a mAb against CD20, expressed on subsets of B cells. Results provide insight into how RTX-induced B cell depletion interferes with RA pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 12 individual sets
Platform:
GPL570
Series:
GSE24742
24 Samples
Download data: CEL, CHP
2.

Effects of tocilizumab versus methotrexate therapy on gene expression profiles in the early rheumatoid arthrtis synovium

(Submitter supplied) Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versus Methotrexate therapy, in synovial biopsy samples collected prospectively in early RA before and 12 weeks after administration of the drug. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS5068 GDS5069
Platform:
GPL570
40 Samples
Download data: CEL
Series
Accession:
GSE45867
ID:
200045867
3.

Gene expression profiles in synovial biopsies from patients with arthritis

(Submitter supplied) Rheumatoid arthritis (RA) is an inflammatory joint disorder that results in progressive joint damage when insufficiently treated. In order to prevent joint destruction and functional disability in RA, early diagnosis and initiation of appropriate treatment with Disease-Modifying Antirheumatic Drugs (DMARDs) is needed. However, in daily clinical practice, patients may initially display symptoms of arthritis that do not fulfil the classification criteria for a definite diagnosis of RA, or any other joint disease, a situation called “Undifferentiated Arthritis” (UA). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4195
Platform:
GPL570
25 Samples
Download data: CEL, CHP
Series
Accession:
GSE36700
ID:
200036700
4.

Effects of Rituximab on global gene expression profiles in the RA synovium

(Submitter supplied) Objective: Rituximab displays therapeutic benefits in the treatment of rheumatoid arthritis (RA) patients resistant to TNF blockade. However, the precise role of B cells in the pathogenesis of RA is still unknown. In this study we investigated the global molecular effects of rituximab in synovial biopsies obtained from anti-TNF resistant RA patients before and after administration of the drug. Methods: Paired synovial biopsies were obtained from the affected knee of anti-TNF resistant RA patients before (T0) and 12 weeks after initiation of rituximab therapy (T12). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4903
Platform:
GPL570
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE24742
ID:
200024742
5.
Full record GDS5069

Rheumatoid arthritic synovium response to methotrexate

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of methotrexate (MTX) therapy. Results compared to those obtained from tocilizumab (TCZ) therapy (GDS5068) and provide insight into the differences in the mechanisms of action between TCZ and MTX.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 8 individual sets
Platform:
GPL570
Series:
GSE45867
16 Samples
Download data: CEL
6.
Full record GDS5068

Rheumatoid arthritic synovium response to tocilizumab

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of tocilizumab (TCZ) therapy. Results compared to those obtained from methotrexate (MTX) therapy (GDS5069) and provide insight into the differences in the mechanisms of action between TCZ and MTX.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 12 individual sets
Platform:
GPL570
Series:
GSE45867
24 Samples
Download data: CEL
7.
Full record GDS4195

Systemic lupus erythematosus and arthritides: synovial biopsies

Analysis of synovial biopsies obtained by needle arthroscopy from affected knees of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or osteoarthritis (OA). Results provide insight into distinct molecular mechanisms underlying SLE arthritis relative to those of OA and RA.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 disease state, 2 gender sets
Platform:
GPL570
Series:
GSE36700
25 Samples
Download data: CEL, CHP
8.

Differential effects of TNFalpha and IL1beta on FLS global gene expression profile

(Submitter supplied) TNFalpha and IL1beta play a pathogenic role in rheumatoid arthritis. Both cytokines are known to activate cytokine and metalloproteinase secretion by synovial fibroblasts. In the present study, we wanted to investigate whether TNFalpha and IL1beta displayed differential effects on cultured Fibroblast-like Synovial Cells derived from RA patients. Global gene expression analyses indicated that both cytokines induced similar genes in these cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE15615
ID:
200015615
9.

Differential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy

(Submitter supplied) TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. These studies also indicate that about 25% of RA patients treated with TNF-antagonists do not display any significant clinical improvement. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
11 Samples
Download data: CEL
Series
Accession:
GSE15602
ID:
200015602
10.

Rheumatoid arthritis and anti-TNF treatment

(Submitter supplied) In 15 patients with rheumatoid arthritis the baseline expression (t=0) of type I IFN-regulated genes was determined in peripheral blood cells (PAXgene) using cDNA-microarrays and compared to levels one month after (t=1) anti-TNF treatment (infliximab). Therefore, we used 43K cDNA microarrays from the Stanford Functional Genomics Facility (http://microarray.org/sfgf/) printed on aminosilane-coated slides containing ~20.000 unique genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL9871 GPL9869 GPL9870
30 Samples
Download data
Series
Accession:
GSE19821
ID:
200019821
11.

Differential expression of rituximab responders vs. non responders on 3 different blood cell types

(Submitter supplied) New and effective therapeutical options are available for the treatment of Rheumatoid Arthritis. One of such treatments is rituximab, and chimeric anti-CD20 antibody that selectively depletes the CD20+ B cell subpopulation. Similar to established anti-TNF alpha therapies, there is a subgroup of RA patients that do not experience significant clinical response. Therefore, one of the major necessities in actual RA therapeutical management is to identify reliable predictors of the response to this therapies. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2507
23 Samples
Download data: TXT
Series
Accession:
GSE15316
ID:
200015316
12.

Transcriptional analysis of normal and pathological synovial fibroblasts

(Submitter supplied) The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from OA, RA and normal synovial tissues. We found larger numbers of transcripts with differential expression in OASF compared to the other groups than in RASF compared to HSF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
31 Samples
Download data: TXT
Series
Accession:
GSE29746
ID:
200029746
13.

Antirheumatic Drug Response in Human Chondrocytes: Potential Molecular Targets to Stimulate Cartilage Regeneration

(Submitter supplied) Rheumatoid arthritis (RA) leads to progressive destruction of articular structures. Despite recent progress in controlling inflammation and pain, little cartilage repair has yet been observed. This in vitro study aims to determine the role of chondrocytes in RA-related cartilage destruction and antirheumatic drug-related regenerative processes. Human chondrocytes were three-dimensionally cultured in alginate beads. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
20 Samples
Download data: CEL, EXP, TXT
Series
Accession:
GSE12860
ID:
200012860
14.

Adapted Boolean Network Models for Extracellular Matrix Formation

(Submitter supplied) Background Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by joint destruction and perpetuated by the synovial membrane (SM). In the inflamed SM, activated synovial fibroblasts (SFB) form the major cell type promoting development and progression of the disease by an abnormal expression/secretion of pro-inflammatory cytokines, tissue-degrading enzymes resulting in a predominant degradation of the extra-cellular matrix (ECM), and collagens causing joint fibrosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
60 Samples
Download data: CEL, CHP
Series
Accession:
GSE13837
ID:
200013837
15.

Synovial fibroblasts, RA versus OA

(Submitter supplied) mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Keywords: disease type comparison, mRNA expression study
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2931
Platform:
GPL8300
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE7669
ID:
200007669
16.
Full record GDS2931

Rheumatoid arthritis and osteoarthritis: synovial fibroblasts

Comparison of synovial fibroblasts from patients with rheumatoid arthritis (RA) to those with osteoarthritis (OA). RA is characterized by chronic inflammation and destruction of multiple joints. OA is a degenerative disease resulting from the breakdown of cartilage.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 other sets
Platform:
GPL8300
Series:
GSE7669
12 Samples
Download data: CEL, CHP
17.

Arthritis and Rheumatism

(Submitter supplied) Synovial tissue mRNA from 21 RA patients and 9 OA patients is hybridized against a common reference sample on lymphochips. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL3262
31 Samples
Download data
Series
Accession:
GSE3848
ID:
200003848
18.

Comparison of gene expression profiles in paired synovial biopsies from rheumatoid arthritis (RA) patients

(Submitter supplied) We explored transcriptomic profiles of paired synovial biopsies from RA patients, in order to assess heterogeneity in synovial tissue at the individual level. Pairwise comparison of transcriptomic profiles showed similar expression of RA-related molecular pathways (TCR signaling, T cell co-stimulation and response to TNF⍺), thereby showing that global molecular alterations in RA synovitis are similar between small and large joints from the same patient.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE153015
ID:
200153015
19.

Key Regulatory Molecules of Cartilage Destruction in Rheumatoid Arthritis: An in vitro Study

(Submitter supplied) We have studied the expression profile of 3D cultured human chondrocytes that were stimulated with supernatant of synovial fibroblasts derived from a RA patient (RASF=HSE cell line) and from a normal donor (NDSF=K4IM cell line), respectively. For this purpose, passage 2 human chondrocytes were cultured for 14 days in alginate beads and subsequently stimulated for 48 hours with supernatant of RASF and NDSF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3158
Platform:
GPL96
6 Samples
Download data: CEL, EXP
Series
Accession:
GSE10024
ID:
200010024
20.
Full record GDS3158

Rheumatoid arthritis-related cartilage destruction model: chondrocytes

Analysis of chondrocytes treated with a supernatant from SV40 T-antigen immortalized human synovial fibroblasts derived from a patient with rheumatoid arthritis (RA). Results provide insight into the molecular mechanism underlying RA-related cartilage destruction.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 3 agent sets
Platform:
GPL96
Series:
GSE10024
6 Samples
Download data: CEL, EXP
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=2|blobid=MCID_61518e4a208db139f37bedae|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center