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Links from GEO DataSets

Items: 5

1.
Full record GDS4928

Acetaminophen effect on thioredoxin reductase 1-null liver

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL8321
Series:
GSE37874
12 Samples
Download data: CEL
2.

Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity

(Submitter supplied) Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity. To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4928
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE37874
ID:
200037874
3.

Mouse Gsr-null and TrxR1/Gsr-null liver transcriptomes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
19 Samples
Download data: CEL
Series
Accession:
GSE124446
ID:
200124446
4.

Elevated Nrf2 response in TrxR1/Gsr-null livers

(Submitter supplied) Liver-specific depletion of both of the cytosolic NADPH-dependent disulfide reductases, TrxR1 and Gsr, was shown to result in increased activation of Nrf2 as compared to elimination of either of these enzymes alone. Activation of transcription factor Nrf2 and its downstream cytoprotective target genes by oxidative and electrophilic insults can protect cells from potentially carcinogenic damage. However, many cancers have an activated Nrf2 response, which can protect cancer cells from oxidative stress radiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
8 Samples
Download data: CEL
Series
Accession:
GSE124445
ID:
200124445
5.

Mouse Gsr-null liver transcriptome

(Submitter supplied) Genetic disruption of Gsr in mouse elicits only subtle changes in the liver transcriptome. Transcriptome analysis of Gsr-null livers was performed to further our understanding of pathways that may compensate for loss of Gsr, one of the two NADPH-dependent cytosolic disulfide reductases.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
11 Samples
Download data: CEL
Series
Accession:
GSE124444
ID:
200124444
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