Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 8

1.
Full record GDS4931

Macrophage response to to Staphylococcus aureus infection in vitro: time course

Analysis of monocyte-derived macrophages that phagocytosed S. aureus in vitro. Monocytes analyzed for up to 48 hours after phagocytosis. Results provide insight into the molecular mechanisms employed by S. aureus to prolong their intracellular survival.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 infection, 3 time sets
Platform:
GPL570
Series:
GSE13670
30 Samples
Download data: CEL, CHP
2.

Gene expression data from S. aureus-exposed macrophages

(Submitter supplied) It is becoming increasingly apparent that Staphylococcus aureus are able to survive engulfment by macrophages, and that the intracellular environment of these cells, which is essential to innate host defenses against invading microorganisms, may in fact provide a refuge for staphylococcal survival and dissemination. Based on this, we postulated that S. aureus might induce cytoprotective mechanisms by changing gene expression profiles inside macrophages similar to obligate intracellular pathogens, such as Mycobacterium tuberculosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4931
Platform:
GPL570
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE13670
ID:
200013670
3.

Gene expression profiling of BM-derived dendritic cells reveals important mechanisms associated with predisposition to Staphylococcus infections

(Submitter supplied) Background: Staphylococcus aureus is a major pathogen of humans and animals and rapidly emerging antibiotic-resistant strains have further increased the severity of this health issue. Host genetics influence susceptibility to S. aureus infections, and genes determining infection outcome should be identified to analyze immune-based therapies as an alternative to antibiotics. Here, we used outbred animals from a divergent selection on susceptibility towards Staphylococcus infection to explore host immunogenetics. more...
Organism:
Ovis aries
Type:
Expression profiling by array
Platform:
GPL10427
44 Samples
Download data
Series
Accession:
GSE24448
ID:
200024448
4.

Genetic Determinants for Susceptibility to Staphylococcus aureus Infection in A/J and C57BL/6J

(Submitter supplied) Although it has recently been shown that A/J mice are highly susceptible to Staphylococcus aureus sepsis as compared to C57BL/6J, the specific genes responsible for this differential phenotype are unknown. Using chromosome substitution strains (CSS), we found that factors on chromosomes (chr) 8, 11, and 18 are responsible for susceptibility to S. aureus sepsis in A/J mice. F1 mice from C57BL/6J X CSS8 cross (C8A) and C57BL/6J X CSS18 (C18A) were also susceptible to S. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
50 Samples
Download data: CEL
Series
Accession:
GSE19668
ID:
200019668
5.

Gene expression data from S. aureus-exposed neutrophils

(Submitter supplied) Neutrophil lysis after phagocytosis is a process potentially important in the pathogenesis of community-associated methicillin-resistant S. aureus (CA-MRSA) infection. The mechanism for this process is not currently known. Therefore, to better understand CA-MRSA virulence we used human oligonucleotide microarrays to investigate the mechanism underlying enhanced PMN lysis that occurs after phagocytosis of CA-MRSA. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
113 Samples
Download data: CEL, CHP
Series
Accession:
GSE16837
ID:
200016837
6.

The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression

(Submitter supplied) The stringent response is initiated by rapid (p)ppGpp synthesis, which leads to a profound reprogramming of gene expression in most bacteria. The stringent phenotype seems to be species specific and may be mediated by fundamentally different molecular mechanisms. In Staphylococcus aureus, (p)ppGpp synthesis upon amino acid deprivation is achieved through the synthase domain of the bifunctional enzyme RSH (RelA/SpoT homolog). more...
Organism:
Staphylococcus aureus
Type:
Expression profiling by array
Platform:
GPL10537
12 Samples
Download data: TXT
Series
Accession:
GSE45617
ID:
200045617
7.

Gene expression of innate immune response in endothelial cells

(Submitter supplied) Gene expression in human umbilical vein endothelial cells (HUVEC) was investigated by microarray analysis after 4 h infection with S. aureus isolated from healthy nasal carriers (n=5) and from blood (n=5) of septic patients. All bacterial isolates were spa-typed and characterized with a DNA microarray to determine the presence of virulence genes. Keywords: infection studies, pathogen, S. aureus
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4030
Platform:
GPL570
12 Samples
Download data: CEL
Series
Accession:
GSE13736
ID:
200013736
8.
Full record GDS4030

HUVECs infected with Staphylococcus aureus isolates from blood and anterior nares

Analysis of human umbilical vein endothelial cells (HUVECs) infected with S. aureus from nares of healthy carriers or from blood of septic patients (i.e. representing a disseminated disease). Results provide insight into interactions between HUVECs and virulent/non-virulent S. aureus isolates.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 infection sets
Platform:
GPL570
Series:
GSE13736
12 Samples
Download data: CEL
DataSet
Accession:
GDS4030
ID:
4030
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=5|blobid=MCID_614d1f9179b8f516c42964fb|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center