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Links from GEO DataSets

Items: 9

1.
Full record GDS4942

Glucose effect on young pancreatic islets: dose response and time course

Analysis of islets isolated from young animals and cultured at 3mM glucose (G3) for 10 hr (T0) and then challenged with 11mM glucose for 1 hr (T1) and 4 hr (T4). Islets cultured at G3 for 2 days were also examined. Results provide insight into the kinetics of molecular response of islets to glucose.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 dose, 4 time sets
Platform:
GPL1261
Series:
GSE42591
8 Samples
Download data: CEL
DataSet
Accession:
GDS4942
ID:
4942
2.

Gene-expression profiles of primary cultures of cortical neurons and astrocytes.

(Submitter supplied) We used microarrays to compare the global programme of gene expression in primary cultures of neurons and astrocytes. These data sets were compared to the expression profiles of other tissues, including pancreatic islets, in order to identify a specific neuroendocrine program in pancreatic islets.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE42607
ID:
200042607
3.

Expression data from fresh and cultured islets at different glucose concentrations

(Submitter supplied) β-cell identity is determined by tightly regulated transcriptional networks that are modulated by extracellular cues, thereby ensuring β-cell adaptation to the organism’s insulin demands. We have observed in pancreatic islets that stimulatory glucose concentrations induced a gene profile that was similar to that of freshly isolated islets, indicating that glucose-elicited cues are involved in maintaining β-cell identity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS4939 GDS4942
Platform:
GPL1261
26 Samples
Download data: CEL
Series
Accession:
GSE42591
ID:
200042591
4.
Full record GDS4939

Glucose effect on young and aged pancreatic islets: dose response

Analysis of islets isolated from young and aged animals and cultured for 2 days at 3 to 16mM glucose (G3 to G16). Freshly-isolated islets were also examined. Ageing is associated with functional changes in beta cells. Results provide insight into the molecular response of aged islets to glucose.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 5 dose, 2 protocol sets
Platform:
GPL1261
Series:
GSE42591
20 Samples
Download data: CEL
DataSet
Accession:
GDS4939
ID:
4939
5.

A Gene Expression Network Model of Type 2 Diabetes Links Cell Cycle

(Submitter supplied) Insulin resistance is necessary but not sufficient for the development of type 2 diabetes. Diabetes results when pancreatic beta-cells fail to compensate for insulin resistance by increasing insulin production through an expansion of beta-cell mass or increased insulin secretion. Communication between insulin target tissues and beta-cells may initiate this compensatory response. Correlated changes in gene expression between tissues can provide evidence for such intercellular communication. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL3677
240 Samples
Download data
Series
Accession:
GSE10785
ID:
200010785
6.

Expression data from pancreatic beta cells isolated from differentially weaned mice.

(Submitter supplied) Transcriptome analysis reveals that in pancreatic beta cells weaning increases the expression of genes involved in replication licensing, suggesting a mechanism to increased responsiveness to the mitogenic activity of high glucose.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
7 Samples
Download data: CEL
Series
Accession:
GSE64524
ID:
200064524
7.

mRNA analysis in different mouse tissues

(Submitter supplied) The functioning of a specific tissue depends on the expression pattern of the different genes. We used microarrays to compare gene expression across different murine tissues, to get a better understanding in the expression pattern and functioning of the different tissues. With this analysis, we were not only able to identify genes that were specifically expressed in a spicific tissue but, as important, we also identified genes that were specifically repressed in a tissue, compared to al the other analysed tissues. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL1261
73 Samples
Download data: CEL
Series
Accession:
GSE24207
ID:
200024207
8.

Circadian gene expression profile of pancreatic islets from C57BL6 mice fed on rodent chow diet collected at 4hr intervals around the clock

(Submitter supplied) Comparison of pancreatic islet transcriptome at 4hr intervals around the clock helps to identify genes that are cycling under the control of the circadian clock. We used Agilent microarrays to analyze pancreatic islet transcriptome at different time points across the circadian cycle.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL11202
6 Samples
Download data: TXT
Series
Accession:
GSE80692
ID:
200080692
9.

Single-Cell RNAseq Reveals That Pancreatic β-Cells From Very Old Male Mice Have a Young Gene Signature

(Submitter supplied) Aging improves pancreatic β-cell function in mice. This is a surprising finding since aging is typically associated with functional decline. We performed single-cell RNA sequencing of β-cells from 3 and 26 month old mice to explore how changes in gene expression contribute to improved function with age. The old mice were healthy, had reduced blood glucose levels and increased β-cell mass, which correlated to their body weight. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
207 Samples
Download data: TXT
Series
Accession:
GSE83146
ID:
200083146
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