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Items: 4

1.
Full record GDS4982

Non-Hodgkin’s lymphoma cell lines response to antibodies against CD20 or B-cell receptor

Analysis of NHL lines treated with CD20 or B-cell receptor (BCR) antibodies. CD20 is a B cell-specific, cell surface protein; BCR has a key role in B cell development. Results provide insight into concordance in molecular changes following BCR activation and anti-CD20 Ab treatment in lymphoma cells.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 8 agent, 4 cell line sets
Platform:
GPL570
Series:
GSE23394
96 Samples
Download data: CEL
2.

Expression data from human NHL cell lines treated with agonistic antibodies

(Submitter supplied) CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antibodies induce very similar expression patterns of up- or down-regulated genes in NHL cell lines indicating that CD20 may play a role in BCR signaling and vice versa. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4982
Platform:
GPL570
96 Samples
Download data: CEL, XLS
Series
Accession:
GSE23394
ID:
200023394
3.

SRC family kinases are involved in the regulation of CD20

(Submitter supplied) CD20 is an integrate membrane protein expressed on the surface of normal and malignant B-cells. It is an excellent molecular target for monoclonal antibodies (mAbs) that are widely used in the treatment of non-Hodgkin’s lymphomas (NHL) and chronic lymphocytic leukemia (CLL). Anti-CD20-directed therapies are the most effective, successful and widely used therapeutic monoclonal antibodies, routinely incorporated into all phases of conventional treatment, including first-line, maintenance and salvage treatment. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16699
8 Samples
Download data: TXT
Series
Accession:
GSE50929
ID:
200050929
4.

Differential regulation patterns of anti-CD20 mAbs in MCL

(Submitter supplied) We investigated the differential regulation patterns of type I anti-CD20 monoclonal antibody (mAb) rituximab and type II obinutuzumab on a transcriptional level. Using a panel of MCL cell lines, we determined the effects of obinutuzumab and rituximab as monotherapies as well as in combination on cell viability and proliferation. Obinutuzumab induced a higher reduction in cell proliferation in each mantle cell lymphoma cell line than rituximab did. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
75 Samples
Download data: CEL
Series
Accession:
GSE54169
ID:
200054169
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