GEO DataSets

Analysis of hypothalami from postnatal day 70 male rats exposed in utero to dioxin at gestational day 15. Rats exposed to dioxin in utero exhibit a reduced pituitary synthesis of luteinizing hormone at the late fetal and early postnatal period, leading to defects in sexual behavior at adulthood.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6101

Series:

GSE48100

6 Samples

Download data

(Submitter supplied) Our previous studies have revealed that treatment of pregnant rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, 1 μg/kg) at gestational day (GD) 15 reduces the pituitary synthesis of luteinizing hormone (LH) during late fetal and early postnatal period, leading to imprinting of defects in sexual behaviors at adulthood. However, it remains obscure how the attenuation of pituitary LH links to sexual immaturity. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS5013 GDS5014

Platform:

GPL6101

12 Samples

Download data: TXT

Analysis of pituitary glands of postnatal day 70 male rats exposed in utero to dioxin at gestational day 15. Rats exposed to dioxin in utero exhibit a reduced pituitary synthesis of luteinizing hormone at the late fetal and early postnatal period, leading to defects in sexual behavior at adulthood.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL6101

Series:

GSE48100

6 Samples

Download data

(Submitter supplied) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes the many forms of reproductive toxicity, such as defects in sexual behaviors, in pups of which mother is exposed to this substance at lower doses. However, the mechanism underlying these defects remains to be clarified in spite of many researches conducted so far. Our previous studies have revealed that maternal treatment with TCDD attenuates the production of pituitary gonadotropins [luteinizing hormone (LH) and follicle-stimulating hormone] in the late fetuses, leading to the impairment of sexual behavior in adulthood. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6101

12 Samples

Download data: TXT

(Submitter supplied) We report the RNAseq-based transcriptome profiles of rat gestation day 20 dam liver, fetal male and female liver, fetal male pituitary, and fetal testis following in utero exposure to either 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 2,3,7,8-tetrachlorodibenzofuran (TCDF). Two exposure models were examined: 1) pregnant rats exposed to either a dose response series of TCDD or TCDF from gestation day 6 - 20 or 2) pregnant rats exposed to a single dose of TCDD or TCDF on gestation day 15. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

260 Samples

Download data: TXT