Similar studies for GEO DataSets (Select 5061) - GEO DataSets

Select item 50611.

Conventional cigarette or modified-risk tobacco product smoke effect on nasal respiratory epithelium: dose response

Analysis of nasal epithelia from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5061

ID:: 5061

Select item 2000502542.

Integration of toxicological end points with molecular measurements in a 28-day rat repeated dose inhalation study with cigarette smoke provides mechanistic understanding of smoke impact

(Submitter supplied) Demonstration of reduced biological effects with a prototypic modified risk tobacco product. Towards a systems toxicology-based risk assessment, we investigated molecular perturbations accompanying histopathological changes in a 28-day rat inhalation study combining transcriptomics with classical histopathology, and demonstrated reduced biological activity of a prototypic modified risk tobacco product (pMRTP) in comparison to the reference research cigarette 3R4F. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Datasets:: GDS5061 GDS5062 GDS5063
Platform:: GPL1355
75 Samples

Download data: CEL

Series

Accession:: GSE50254

ID:: 200050254

Select item 50633.

Conventional cigarette or modified-risk tobacco product smoke effect on lung bronchial epithelium: dose response

Analysis of left lung bronchi from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5063

ID:: 5063

Select item 50624.

Conventional cigarette or modified-risk tobacco product smoke effect on lung parenchyma: dose response

Analysis of left lung parenchyma from males that were nose-only exposed for 28 days to smoke from reference cigarette 3R4F at doses up to 23ug nicotine/l or from a modified risk tobacco product (MRTP) at a dose of 23ug nicotine/l. Results provide insight into the reduced biological activity of MRTP.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:: GPL1355
Series:: GSE50254
25 Samples

Download data: CEL

DataSet

Accession:: GDS5062

ID:: 5062

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