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Links from GEO DataSets

Items: 20

1.
Full record GDS5069

Rheumatoid arthritic synovium response to methotrexate

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of methotrexate (MTX) therapy. Results compared to those obtained from tocilizumab (TCZ) therapy (GDS5068) and provide insight into the differences in the mechanisms of action between TCZ and MTX.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 8 individual sets
Platform:
GPL570
Series:
GSE45867
16 Samples
Download data: CEL
2.

Effects of tocilizumab versus methotrexate therapy on gene expression profiles in the early rheumatoid arthrtis synovium

(Submitter supplied) Rheumatoid arthritis (RA) is a chronic, systemic autoimmune inflammatory disease that is characterized by the presence of inflammatory cytokines, including interleukin-6 (IL-6). Here, we investigated the global molecular effects of Tocilizumab, an approved humanized anti-IL6 Receptor antibody, versus Methotrexate therapy, in synovial biopsy samples collected prospectively in early RA before and 12 weeks after administration of the drug. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS5068 GDS5069
Platform:
GPL570
40 Samples
Download data: CEL
Series
Accession:
GSE45867
ID:
200045867
3.

Gene expression profiles in synovial biopsies from patients with arthritis

(Submitter supplied) Rheumatoid arthritis (RA) is an inflammatory joint disorder that results in progressive joint damage when insufficiently treated. In order to prevent joint destruction and functional disability in RA, early diagnosis and initiation of appropriate treatment with Disease-Modifying Antirheumatic Drugs (DMARDs) is needed. However, in daily clinical practice, patients may initially display symptoms of arthritis that do not fulfil the classification criteria for a definite diagnosis of RA, or any other joint disease, a situation called “Undifferentiated Arthritis” (UA). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4195
Platform:
GPL570
25 Samples
Download data: CEL, CHP
Series
Accession:
GSE36700
ID:
200036700
4.

Effects of Rituximab on global gene expression profiles in the RA synovium

(Submitter supplied) Objective: Rituximab displays therapeutic benefits in the treatment of rheumatoid arthritis (RA) patients resistant to TNF blockade. However, the precise role of B cells in the pathogenesis of RA is still unknown. In this study we investigated the global molecular effects of rituximab in synovial biopsies obtained from anti-TNF resistant RA patients before and after administration of the drug. Methods: Paired synovial biopsies were obtained from the affected knee of anti-TNF resistant RA patients before (T0) and 12 weeks after initiation of rituximab therapy (T12). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4903
Platform:
GPL570
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE24742
ID:
200024742
5.
Full record GDS5068

Rheumatoid arthritic synovium response to tocilizumab

Analysis of synovial biopsies from rheumatoid arthritis patients before and 12 weeks after the start of tocilizumab (TCZ) therapy. Results compared to those obtained from methotrexate (MTX) therapy (GDS5069) and provide insight into the differences in the mechanisms of action between TCZ and MTX.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 12 individual sets
Platform:
GPL570
Series:
GSE45867
24 Samples
Download data: CEL
6.
Full record GDS4903

Rheumatoid arthritic synovium response to rituximab

Analysis of synovial biopsy samples from anti-TNF resistant rheumatoid arthritis (RA) patients 12 wks after the start of rituximab (RTX) therapy. RTX is a mAb against CD20, expressed on subsets of B cells. Results provide insight into how RTX-induced B cell depletion interferes with RA pathogenesis.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 12 individual sets
Platform:
GPL570
Series:
GSE24742
24 Samples
Download data: CEL, CHP
7.
Full record GDS4195

Systemic lupus erythematosus and arthritides: synovial biopsies

Analysis of synovial biopsies obtained by needle arthroscopy from affected knees of patients with systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or osteoarthritis (OA). Results provide insight into distinct molecular mechanisms underlying SLE arthritis relative to those of OA and RA.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 5 disease state, 2 gender sets
Platform:
GPL570
Series:
GSE36700
25 Samples
Download data: CEL, CHP
8.

Differential effects of TNFalpha and IL1beta on FLS global gene expression profile

(Submitter supplied) TNFalpha and IL1beta play a pathogenic role in rheumatoid arthritis. Both cytokines are known to activate cytokine and metalloproteinase secretion by synovial fibroblasts. In the present study, we wanted to investigate whether TNFalpha and IL1beta displayed differential effects on cultured Fibroblast-like Synovial Cells derived from RA patients. Global gene expression analyses indicated that both cytokines induced similar genes in these cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE15615
ID:
200015615
9.

Differential gene expression in RA synovial biopsies from responders versus non-responders to adalimumab therapy

(Submitter supplied) TNF antagonists are routinely used in severe rheumatoid arthritis (RA) patients who failed conventional DMARD therapy. According to large clinical trials, the three available drugs (adalimumab, infliximab and etanercept) display similar effects in terms of efficacy, tolerability and side effects. These studies also indicate that about 25% of RA patients treated with TNF-antagonists do not display any significant clinical improvement. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
11 Samples
Download data: CEL
Series
Accession:
GSE15602
ID:
200015602
10.

Transcriptomic effects of TNFa in primary fibroblast-like synovial cell cultures

(Submitter supplied) Gene expression profiles in synovial biopsies from patients with rheumatoid arthritis (RA) display a high level of plasticity related to disease activity and response to therapy. In order to identify TNFa-dependent genes in ex vivo RA or other synovial biopsies, we generated the present set of data using primary fibroblast-like synovial cell (FLS) cultures incubated overnight in the presence or the absence of TNFa.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE73764
ID:
200073764
11.

RNAseq study of synovial biopsies after triple DMARD treatment

(Submitter supplied) Total RNA sequencing was performed on samples isolated from joint synovial biopsies from subjects with rheumatoid arthritis before and after 6 months of triple DMARD treatment
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
38 Samples
Download data: TXT
Series
Accession:
GSE97165
ID:
200097165
12.

RNAseq study of synovial biopsies

(Submitter supplied) Total RNA sequencing was performed on samples isolated from joint synovial biopsies from subjects with and without rheumatoid arthritis
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
218 Samples
Download data: TXT
Series
Accession:
GSE89408
ID:
200089408
13.

Antirheumatic Drug Response in Human Chondrocytes: Potential Molecular Targets to Stimulate Cartilage Regeneration

(Submitter supplied) Rheumatoid arthritis (RA) leads to progressive destruction of articular structures. Despite recent progress in controlling inflammation and pain, little cartilage repair has yet been observed. This in vitro study aims to determine the role of chondrocytes in RA-related cartilage destruction and antirheumatic drug-related regenerative processes. Human chondrocytes were three-dimensionally cultured in alginate beads. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
20 Samples
Download data: CEL, EXP, TXT
Series
Accession:
GSE12860
ID:
200012860
14.

The relationship between the gene expression profile in the synovium of RA patients at baseline and the clinical response to infliximab treatment

(Submitter supplied) Background: Although the use of TNF inhibitors has fundamentally changed the way rheumatoid arthritis (RA) is treated, not all patients respond well. It is desirable to facilitate the identification of responding and non-responding patients prior to treatment, not only to avoid unnecessary treatment but also for financial reasons. In this work we have investigated the transcriptional profile of synovial tissue sampled from RA patients before anti-TNF treatment with the aim to identify biomarkers predictive of response. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7768
62 Samples
Download data: GPR
Series
Accession:
GSE21537
ID:
200021537
15.

Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study

(Submitter supplied) The aim of this study was to identify the specific molecular biological features predicting the therapeutic outcomes of three bDMARDs, infliximab (IFX), tocilizumab (TCZ), and abatacept (ABT) by studying blood gene expression signature of patients prior to biologic treatment in a unified test platform. GSEA analyses showed that inflammasome genes were significantly upregulated in IFX’s NON-REM compared with its REM. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
209 Samples
Download data: TXT
Series
Accession:
GSE78068
ID:
200078068
16.

Gene expression profiling of rheumatoid arthritis synovial tissues

(Submitter supplied) Spots were selected that had an expression level higher than 1.6 the local background. The use of a common reference sample allows the comparison of the relative expression levels across the tissue samples. All genes were expressed relative to their median expression level across the arrays of the same microarray platform, allowing us to combine the data from the 2 platforms. Data from Lymphochip and Stanford Human cDNA arrays was combined per patient. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
4 related Platforms
28 Samples
Download data
Series
Accession:
GSE9027
ID:
200009027
17.

Transcriptional analysis of normal and pathological synovial fibroblasts

(Submitter supplied) The aim of this study was to compare gene expression between two pathological groups of human synovial fibroblasts (SF) from rheumatoid arthritis (RA) and osteoarthritis (OA) synovial tissues with normal SF from healthy individuals (HSF). We used microarray expression profiling in SF cultured from OA, RA and normal synovial tissues. We found larger numbers of transcripts with differential expression in OASF compared to the other groups than in RASF compared to HSF. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
31 Samples
Download data: TXT
Series
Accession:
GSE29746
ID:
200029746
18.

Adapted Boolean Network Models for Extracellular Matrix Formation

(Submitter supplied) Background Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by joint destruction and perpetuated by the synovial membrane (SM). In the inflamed SM, activated synovial fibroblasts (SFB) form the major cell type promoting development and progression of the disease by an abnormal expression/secretion of pro-inflammatory cytokines, tissue-degrading enzymes resulting in a predominant degradation of the extra-cellular matrix (ECM), and collagens causing joint fibrosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
60 Samples
Download data: CEL, CHP
Series
Accession:
GSE13837
ID:
200013837
19.

Synovial fibroblasts, RA versus OA

(Submitter supplied) mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Keywords: disease type comparison, mRNA expression study
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2931
Platform:
GPL8300
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE7669
ID:
200007669
20.
Full record GDS2931

Rheumatoid arthritis and osteoarthritis: synovial fibroblasts

Comparison of synovial fibroblasts from patients with rheumatoid arthritis (RA) to those with osteoarthritis (OA). RA is characterized by chronic inflammation and destruction of multiple joints. OA is a degenerative disease resulting from the breakdown of cartilage.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 other sets
Platform:
GPL8300
Series:
GSE7669
12 Samples
Download data: CEL, CHP
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