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Links from GEO DataSets

Items: 20

1.
Full record GDS5074

First-time acute myocardial infarction: peripheral blood

Analysis of circulating blood from first-time acute myocardial infarction (AMI) patients within 48 hours of MI. Results provide insight into molecular mechanisms underlying the response of circulating cells to first-time AMI.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE48060
52 Samples
Download data: CEL
2.

Transcriptome from circulating cells suggests dysregulated pathways associated with long-term recurrent events following first-time myocardial infarction.

(Submitter supplied) Whole-genome gene expression analysis has been successfully utilized to diagnose, prognosticate, and identify potential therapeutic targets for cardiovascular disease. However, the utility of this approach to identify outcome-related genes and dysregulated pathways following first-time myocardial infarction (AMI) remains unknown and may offer a novel strategy to detect affected expressome networks that predict long-term outcome. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS5022 GDS5074
Platform:
GPL570
52 Samples
Download data: CEL
Series
Accession:
GSE48060
ID:
200048060
3.
Full record GDS5022

First-time acute myocardial infarction patients with or without recurrent event: peripheral blood

Analysis of blood from first-time acute myocardial infarction (AMI) patients, clinically indistinguishable at baseline, with or without recurrent cardiovascular events at 18 months. Results provide insight into molecular mechanisms distinguishing AMI patients with or without recurrent events.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state sets
Platform:
GPL570
Series:
GSE48060
31 Samples
Download data: CEL
4.

Bmi1 defines long-term adult cardiac stem cells in heart homeostasis and repair

(Submitter supplied) We have found the existence of a Bmi1+ population in the adult heart contributing to the organ low-rate turnover and repair with the generation of new cardiomyocytes. We show that the Bmi1+ population is a sub-population of the cardiac Sca-1+ progenitor cells. We have analyzed the gene profile by deep-sequencing (RNA-Seq) of Bmi1+ and Sca-1+Bmi1- cells in homeostatic heart condition. On the other hand, we have compared gene profile by deep-sequencing (RNA-Seq) of Bmi1+ cells in homeostatic condition versus Bmi1+ cells 5 days after myocardial infarction (MI). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11002
12 Samples
Download data: XLS
Series
Accession:
GSE55754
ID:
200055754
5.

Transcriptional Profiling of Human Liver Identifies Sex-Biased Genes Associated with Polygenic Dyslipidemia and Coronary Artery Disease

(Submitter supplied) Sex-differences in human liver gene expression were characterized on a genome-wide scale using a large liver sample collection, allowing for detection of small expression differences with high statistical power. 1,249 sex-biased genes were identified, 70% showing higher expression in females. Chromosomal bias was apparent, with female-biased genes enriched on chrX and male-biased genes enriched on chrY and chr19, where 11 male-biased zinc-finger KRAB-repressor domain genes are distributed in six clusters. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
16 Samples
Download data: TXT
Series
Accession:
GSE23766
ID:
200023766
6.

RNA-seq analysis of human heart failure

(Submitter supplied) The goal of this study is to compare the transcriptome of heart failure patients (with ischemic or dilated cardiomyopathy) undergoing heart transplantation compared with healthy controls.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16288
36 Samples
Download data: TXT
Series
Accession:
GSE55296
ID:
200055296
7.

Altered expression of microRNAs in the myocardium of rats with acute myocardial infarction

(Submitter supplied) MicroRNAs are important cellular components and their dysfunctions are associated with various disease. Acute myocardial infarction (AMI) is one of the most serious cardiovascular diseases. Although several miRNAs have been reported to be associated with AMI, more novel miRNAs are needed to be investigated to ascertain if they are associated with AMI.
Organism:
Rattus norvegicus; Mus musculus; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL9837
12 Samples
Download data: LSR
Series
Accession:
GSE19695
ID:
200019695
8.

Rat LAD IR study

(Submitter supplied) Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Keywords: rat heart ventricles, LAD - left anterior descending coronary artery, IR - ischemia-reperfusion
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS1959
Platform:
GPL341
12 Samples
Download data
Series
Accession:
GSE4105
ID:
200004105
9.
Full record GDS1959

Ischemic myocardium response to reperfusion

Analysis of ischemic heart ventricles 2 or 7 days after reperfusion. Ischemia induced by occlusion of the left anterior descending coronary artery. Results provide insight into the molecular mechanisms involved in the early and late inflammatory phases of acute myocardial infarction.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 protocol, 2 time sets
Platform:
GPL341
Series:
GSE4105
12 Samples
Download data
DataSet
Accession:
GDS1959
ID:
1959
10.

Identification of Novel Serum Biomarkers for Early Decision of ST-elevation Myocardial Infarction

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6106 GPL6884
57 Samples
Download data
Series
Accession:
GSE61145
ID:
200061145
11.

Expression data from blood samples of STEMI and Same STEMI patients after PIC

(Submitter supplied) We aim to determine blood transcriptome-based molecular signature of acute coronary syndrome (ACS), and to identify novel serum biomarkers for early stage ST-segment-elevation myocardial infarction (STEMI)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6106
24 Samples
Download data: TXT
Series
Accession:
GSE61144
ID:
200061144
12.

Assessment and Diagnostic Relevance of Novel Serum Biomarkers for Early Decision of ST-elevation Myocardial Infarction

(Submitter supplied) We aim to determine blood transcriptome-based molecular signature of acute coronary syndrome (ACS), and to identify novel serum biomarkers for early stage ST-segment-elevation myocardial infarction (STEMI)
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
33 Samples
Download data: TXT
Series
Accession:
GSE60993
ID:
200060993
13.

Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction.

(Submitter supplied) Recent technological advances have made transcriptome sequencing (RNA-seq) possible in cells with low RNA copy number including platelets. Resulting studies have used RNA-seq in platelets isolated from healthy individuals to characterize the platelet transcriptome. However, platelets, possibly through gene expression changes, contribute to the etiology of and response to cardiovascular disease and events. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
34 Samples
Download data: CSV, XLS
Series
Accession:
GSE65705
ID:
200065705
14.

Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction

(Submitter supplied) Despite a substantial progress in diagnosis and therapy, acute myocardial infarction (MI) is a major cause of mortality in the general population. A novel insight into the pathophysiology of myocardial infarction obtained by studying gene expression should help to discover novel biomarkers of MI and to suggest novel strategies of therapy. The aim of our study was to establish gene expression patterns in leukocytes from acute myocardial infarction patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
98 Samples
Download data: CEL
Series
Accession:
GSE62646
ID:
200062646
15.

Expression data from advanced stage of murine pancreatic ductal adenocarcinoma (PDAC) and control pancreas

(Submitter supplied) We used microarrays to detail the global gene expression signature of PDAC and to identify distinct up- and down-regulated transcripts in these tumors compared to control pancreas. We also established from this dataset the metabolic signature of PDAC in order to define new metabolic therapeutic target for pancreatic cancer.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE61412
ID:
200061412
16.

Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL8091
111 Samples
Download data: CEL, TXT
Series
Accession:
GSE24188
ID:
200024188
17.

Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Affymetrix platform]

(Submitter supplied) With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well as a model substance for induction of nuclear receptor PXR. Expression profiling with Affymetrix whole genome arrays shows that statins induce extensive transcriptome changes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
40 Samples
Download data: CEL
Series
Accession:
GSE24187
ID:
200024187
18.

Atorvastatin, rosuvastatin and rifampicin effect on human primary hepatocyte transcriptome [Steroltalk platform]

(Submitter supplied) With particular emphasis on interactions between cholesterol homeostasis and drug metabolism we investigate the transcriptome of human primary hepatocytes treated by two commonly prescribed cholesterol lowering drugs atorvastatin and rosuvastatin and by rifampicin that serves as an outgroup as well as a model substance for induction of nuclear receptor PXR. Expression profiling with dedicated Steroltalk cDNA arrays shows that statins induce extensive transcriptome changes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8091
71 Samples
Download data: TXT
Series
Accession:
GSE24186
ID:
200024186
19.

Earliest Changes in the Left Ventricular Transcriptome Post-Myocardial Infarction

(Submitter supplied) We report a genome-wide survey of early responses of the mouse heart transcriptome to acute myocardial infarction (AMI). For three regions of the left ventricle (LV), namely ischemic/infarcted tissue (IF), the surviving LV free wall (FW) and the interventricular septum (IVS), 36,899 transcripts were assayed at six time points from 15 min to 48 h post-AMI in both AMI and sham surgery mice. For each transcript, temporal expression patterns were systematically compared between AMI and sham groups, which identified 515 AMI-responsive genes in IF tissue, 35 in the FW, 7 in the IVS, with three genes induced in all three regions. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS2329 GDS2330 GDS2331
Platforms:
GPL83 GPL81 GPL82
198 Samples
Download data: CEL
Series
Accession:
GSE4648
ID:
200004648
20.
Full record GDS2331

Acute myocardial infarction model: time course (MG-U74C)

Analysis of left heart ventricles (LV) at various time points up to 48 hours following surgically induced acute myocardial infarction (AMI). Ischemic/infarcted tissue, surviving free wall, and the interventricular septum of LV examined. Results provide insight into the molecular pathogenesis of AMI.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 disease state, 7 time, 4 tissue sets
Platform:
GPL83
Series:
GSE4648
66 Samples
Download data: CEL
DataSet
Accession:
GDS2331
ID:
2331
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