GEO DataSets

Analysis of cerebella from pre-symptomatic, postnatal day 7 cystatin B (CSTB)-deficient mice. Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disease caused by mutations in the CSTB gene. Results provide insight into the molecular basis of EPM1 pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE47516

8 Samples

Download data: CEL

(Submitter supplied) Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized the cystatin B deficient mice (Cstb-/-), a model for the disease. We have characterized the gene expression changes from the cerebellum of Cstb-/- mouse at postnatal day 7 (P7) and P30 as well as in cultured cerebellar granule cells using a pathway-based approach. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS5089 GDS5090 GDS5091

Platform:

GPL1261

21 Samples

Download data: CEL

Analysis of granule cells dissected from postnatal day 5 cystatin B (CSTB)-deficient mice and cultured for 2 days. Progressive myoclonus epilepsy Unverricht-Lundborg type (EPM1) is a neurodegenerative disease caused by CSTB gene mutations. Results provide insight into the molecular basis of EPM1.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE47516

7 Samples

Download data: CEL

Analysis of cerebella from symptomatic, postnatal day 30 cystatin B (CSTB)-deficient mice. Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disease caused by mutations in the CSTB gene. Results provide insight into the molecular basis of EPM1 pathogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE47516

6 Samples

Download data: CEL

(Submitter supplied) Cystain B (Cstb) is a ubiquitously expressed cysteine protease inhibitor and mutations of the CSTB gene lead to the neurodegenerative disease progressive myoclonus epilepsy of Unverricht-Lundorg type (EPM1). We are interested in the microglia-specific, Cstb-dependent gene-expression changes in mice and in this data set, we include gene-level expression data from cultured primary microglia of control and Cstb-/- mice extracted from neonatal mice at P5 and we identified 156 differentially-expressed genes in Cstb-/- microglia.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

8 Samples

Download data: CEL

(Submitter supplied) Genetic ablation of Ezh2 in Pax7-Cre driven lineages resulted in developmental defects in E13.5 cerebellum. The transcriptional change and H3K27me3 mark change were investigated by RNA-seq and ChIP-seq on H3K27me3.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:

GPL17021

10 Samples

Download data: BW, WIG, XLSX

(Submitter supplied) The beneficial effects of dietary restriction (DR) are associated with a rearrangement of gene expression that modulate metabolic and cytoprotective pathways. However, the effect of DR on the cerebellar transcriptome remained to be fully defined. Therefore we analyzed the effect of 30% DR on the transcriptome of cerebellar cortex of young-adult male mice using RNAseq.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

12 Samples

Download data: TXT