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Links from GEO DataSets

Items: 5

1.
Full record GDS5090

Cystatin B knockout model of progressive myoclonus epilepsy: postnatal day 30 cerebellum

Analysis of cerebella from symptomatic, postnatal day 30 cystatin B (CSTB)-deficient mice. Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disease caused by mutations in the CSTB gene. Results provide insight into the molecular basis of EPM1 pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE47516
6 Samples
Download data: CEL
2.

Gene expression alterations in the cerebellum and granule neurons of Cstb-/- mouse are associated with early synaptic changes and inflammation

(Submitter supplied) Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is an inherited neurodegenerative disease with myoclonus, seizures and ataxia, caused by the mutations in cystatin B (CSTB) gene. In an approach towards understanding the molecular basis of pathogenic events in EPM1 we have utilized the cystatin B deficient mice (Cstb-/-), a model for the disease. We have characterized the gene expression changes from the cerebellum of Cstb-/- mouse at postnatal day 7 (P7) and P30 as well as in cultured cerebellar granule cells using a pathway-based approach. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS5089 GDS5090 GDS5091
Platform:
GPL1261
21 Samples
Download data: CEL
Series
Accession:
GSE47516
ID:
200047516
3.
Full record GDS5091

Cystatin B knockout model of progressive myoclonus epilepsy: cultured cerebellar granule cells

Analysis of granule cells dissected from postnatal day 5 cystatin B (CSTB)-deficient mice and cultured for 2 days. Progressive myoclonus epilepsy Unverricht-Lundborg type (EPM1) is a neurodegenerative disease caused by CSTB gene mutations. Results provide insight into the molecular basis of EPM1.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE47516
7 Samples
Download data: CEL
4.
Full record GDS5089

Cystatin B knockout model of progressive myoclonus epilepsy: postnatal day 7 cerebellum

Analysis of cerebella from pre-symptomatic, postnatal day 7 cystatin B (CSTB)-deficient mice. Progressive myoclonus epilepsy of Unverricht-Lundborg type (EPM1) is a neurodegenerative disease caused by mutations in the CSTB gene. Results provide insight into the molecular basis of EPM1 pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE47516
8 Samples
Download data: CEL
5.

Gene expression data of cultured primary microglia from neonatal control and Cstb-/- mice.

(Submitter supplied) Cystain B (Cstb) is a ubiquitously expressed cysteine protease inhibitor and mutations of the CSTB gene lead to the neurodegenerative disease progressive myoclonus epilepsy of Unverricht-Lundorg type (EPM1). We are interested in the microglia-specific, Cstb-dependent gene-expression changes in mice and in this data set, we include gene-level expression data from cultured primary microglia of control and Cstb-/- mice extracted from neonatal mice at P5 and we identified 156 differentially-expressed genes in Cstb-/- microglia.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6096
8 Samples
Download data: CEL
Series
Accession:
GSE64823
ID:
200064823
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