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Links from GEO DataSets

Items: 20

1.
Full record GDS5164

GATA-3 deficiency effect on regulatory T cell

Analysis of regulatory T (Treg) cells from mutants deficient for the transcription factor GATA-3. GATA-3 forms a complex with the transcription factor Fox3p, essential in the function of Treg cells. Results provide insight into the role of GATA-3 in the regulation of the Treg transcriptome.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE39864
6 Samples
Download data: CEL
2.

Treg specific Gata3 knock out array

(Submitter supplied) The transcription factor Foxp3 is indispensible for the differentiation and function of regulatory T cells (Treg cells). To gain insights into the molecular mechanisms of Foxp3 mediated gene expression we purified Foxp3 complexes and explored their composition. Biochemical and mass-spectrometric analyses revealed that Foxp3 forms multi-protein complexes of 400-800 kDa or larger and identified 361 associated proteins ~30% of which are transcription-related. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5164
Platform:
GPL8321
6 Samples
Download data: CEL
Series
Accession:
GSE39864
ID:
200039864
3.

Foxo1/3-deficient Treg cells

(Submitter supplied) Identification of Foxos target genes in Treg cells. Foxo1and Foxo3 are transcription factors of Foxo family. CD4+Foxp3+ Treg cells isolated from wild-type and Foxo1/3-deficient mice were analyzed by global gene expression profiling. Results indicate Foxos regulate expression of a subset of Treg cell signature genes and genes in control of T cell homeostasis, signaling and metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE21678
ID:
200021678
4.

Foxp3 ablation in peripheral mature regulatory T cells

(Submitter supplied) Analysis of Foxp3 ablated peripheral regulatory T cells. Regulatory T cells require the expression of the transcription factor Foxp3 for thymic development. It is not known whether continuous expression of Foxp3 is required for the maintained function of mature regulatory T cells in the periphery. Results indicate changes to the regulatory T cell developmental program in the absence of Foxp3. Keywords: genetic modification
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS2525
Platform:
GPL1261
4 Samples
Download data: CEL
Series
Accession:
GSE6681
ID:
200006681
5.
Full record GDS2525

Foxp3 ablation effect on mature regulatory T cells

Analysis of mature regulatory T cells (Treg) ablated for the transcription factor Foxp3. Foxp3 is required for the development of Treg cells. Results provide insight into the role of Foxp3 in maintaining the transcriptional and functional program established during Treg cell development.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL1261
Series:
GSE6681
4 Samples
Download data: CEL
DataSet
Accession:
GDS2525
ID:
2525
6.

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Other
Platforms:
GPL24057 GPL6246
156 Samples
Download data: CEL, RCC
Series
Accession:
GSE104346
ID:
200104346
7.

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes [microarray]

(Submitter supplied) Microarray profiles of M176, M354 and WT FoxP3 -transdued (in vitro) and -Treg from mice
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE104345
ID:
200104345
8.

FoxP3 scanning mutagenesis reveals functional variegation and mild mutations with atypical autoimmune phenotypes [nanostring]

(Submitter supplied) Nanostring profiles of CD4+ T cells transduced with EV, WT or FoxP3 mutants
Organism:
Mus musculus
Type:
Other
Platform:
GPL24057
144 Samples
Download data: RCC
Series
Accession:
GSE104344
ID:
200104344
9.

Different molecular complexes that mediate transcriptional induction and repression by FoxP3

(Submitter supplied) ChIP-seq profile of WT or mutant FoxP3 in CD4+ T cells
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
11 Samples
Download data: BIGWIG
Series
Accession:
GSE102281
ID:
200102281
10.

Murine iTreg cells: Control (MIEG3) vs. YY1-expression vector transduced

(Submitter supplied) Transcriptional profiling of mouse induced Treg (iTreg) cells comparing control (MIEG3) vector-transduced iTreg cells with iTreg cells transduced with YY1-overexpression vector. Tranduced cells were sorted by GFP expression. Goal was to determine the effects of YY1 on global iTreg gene expression.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
1 Sample
Download data: TXT
Series
Accession:
GSE75052
ID:
200075052
11.

A multiply redundant genetic switch locks in the transcriptional signature of T regulatory cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL9185 GPL6246
64 Samples
Download data: BED, BIGWIG, BW, CEL, WIG
Series
Accession:
GSE40278
ID:
200040278
12.

Gene profiling data of CD4+ T cells doubly transduced with EOS+LEF1 or GATA1+SATB1

(Submitter supplied) The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE40277
ID:
200040277
13.

Gene profiling data of CD4+ T cells transduced with FOXP3 and GATA1, then sorted into different fractions, based on the expression of Thy1.1 (FOXP3)

(Submitter supplied) The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
7 Samples
Download data: CEL
Series
Accession:
GSE40276
ID:
200040276
14.

Gene profiling data of CD4+ T cells transduced with FOXP3 and candidate cofactors

(Submitter supplied) The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
33 Samples
Download data: CEL
Series
Accession:
GSE40274
ID:
200040274
15.

Gene expression profiling in Treg cells deficient or mutant in candidate FoxP3 cofactors

(Submitter supplied) The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE40273
ID:
200040273
16.

Genome-wide maps of FoxP3 binding in transduced CD4+ T cells

(Submitter supplied) The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. Computational network inference and experimental testing assessed the contribution of several other transcription factors (TFs). Enforced expression of Helios or Xbp1 elicited specific signatures, but Eos, Irf4, Satb1, Lef1 and Gata1 elicited exactly the same outcome, synergizing with FoxP3 to activate most of the Treg signature, including key TFs, and enhancing FoxP3 occupancy at its genomic targets. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9185
4 Samples
Download data: BED, BIGWIG, BW, WIG
Series
Accession:
GSE40238
ID:
200040238
17.

Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL1261 GPL11002
10 Samples
Download data: BED, CEL
Series
Accession:
GSE40657
ID:
200040657
18.

Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [ChIP-Seq]

(Submitter supplied) Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas the early Treg cell lineage commitment is regulated by the Akt kinase and the forkhead box O (Foxo) family of transcription factors6-10. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11002
4 Samples
Download data: BED
Series
Accession:
GSE40656
ID:
200040656
19.

Novel Foxo1-dependent Transcriptional Programs Control Treg Cell Function [Affymetrix gene expression data]

(Submitter supplied) Regulatory T (Treg) cells characterized by expression of the transcription factor forkhead box P3 (Foxp3) maintain immune homeostasis by suppressing self-destructive immune responses1-4. Foxp3 operates as a late acting differentiation factor controlling Treg cell homeostasis and function5, whereas the early Treg cell lineage commitment is regulated by the Akt kinase and the forkhead box O (Foxo) family of transcription factors6-10. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE40655
ID:
200040655
20.

AKT regulates de novo induction of Foxp3

(Submitter supplied) The CD4+Foxp3+ regulatory T cells play an essential role in maintaining tolerance via their suppressive function on conventional T cells. The intracellular signaling pathways that regulate Foxp3 expression are largely unknown. In this study we describe a novel inhibitory role for AKT in regulating de novo induction of Foxp3 both in vivo and in vitro. A constitutively active allele of AKT significantly diminished TGF-â induced Foxp3 induction via a rapamycin-sensitive pathway, establishing a role for the AKT-mTOR axis in Treg cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE7596
ID:
200007596
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