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Links from GEO DataSets

Items: 20

1.
Full record GDS5199

Silica-induced pulmonary toxicity: blood (part III)

Analysis of blood samples from Fischer animals 16 hours following inhalation of crystalline silica at a concentration of 1 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL6101
Series:
GSE27023
12 Samples
Download data
DataSet
Accession:
GDS5199
ID:
5199
2.

Blood gene expression profile of control and crystalline silica exposed rats

(Submitter supplied) The present research aimed to investigate peripheral blood gene expression profiling as a minimally invasive surrogate approach to study silica-induced pulmonary toxicity. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 hours/day, 5 days). Pulmonary damage and blood gene expression profiles were determined at various latency periods (0 - 16 weeks). Silica exposure resulted in pulmonary toxicity and this was evidenced by histological changes in the lungs and elevation of LDH activity, and total protein and albumin contents in the bronchoalveolar lavage fluid (BALF) of the rats. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS5197 GDS5198 GDS5199
Platform:
GPL6101
96 Samples
Download data: TXT
Series
Accession:
GSE27023
ID:
200027023
3.
Full record GDS5198

Silica-induced pulmonary toxicity: blood (part II)

Analysis of blood samples from Fischer animals 16 hours following inhalation of crystalline silica at a concentration of 2 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent sets
Platform:
GPL6101
Series:
GSE27023
12 Samples
Download data
DataSet
Accession:
GDS5198
ID:
5198
4.
Full record GDS5197

Silica-induced pulmonary toxicity: blood (part I)

Analysis of blood samples from Fischer animals for up to 16 weeks following inhalation of crystalline silica at a concentration of 15 mg/m3, 6 h/day for 5 consecutive days. Results provide insight into the utility of blood gene expression profiling to detect pulmonary toxicity induced by silica.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 agent, 6 time sets
Platform:
GPL6101
Series:
GSE27023
72 Samples
Download data
DataSet
Accession:
GDS5197
ID:
5197
5.

Transcriptomics Analysis of Lungs and Peripheral Blood of Crystalline Silica Exposed Rats

(Submitter supplied) Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity. Rats were exposed by inhalation to crystalline silica for one week (15 mg/m3, 6-hours/day, 5 days/week). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
24 Samples
Download data: TXT
Series
Accession:
GSE36208
ID:
200036208
6.

Molecular mechanisms of pulmonary response progression in crystalline silica exposed rats

(Submitter supplied) The capability to detect target organ toxicity as well as to determine the molecular mechanisms underlying such toxicity by employing surrogate biospecimens that can be obtained by a non-invasive or minimally invasive procedure has significant advantage in occupational toxicology. Pulmonary toxicity and global gene expression profile in the lungs, peripheral blood and bronchoalveolar lavage (BAL) cells were determined in rats at 44-weeks following pulmonary exposure to crystalline silica (15 mg/m3, 6-hours/day, 5 days). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
36 Samples
Download data: TXT
Series
Accession:
GSE41572
ID:
200041572
7.

Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats

(Submitter supplied) Occupational exposure to crystalline silica results in serious health effects, most notably, silicosis and cancer. A proper understanding of the mechanism(s) underlying the initiation and progression of silica-induced pulmonary toxicity is critical for the intervention and/or prevention of the adverse health effects associated with crystalline silica exposure. Rats were exposed to crystalline silica by inhalation at a concentration of 15 mg/m3, 6 hours/day, 5 days/week for 3, 6 or 12 weeks. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
36 Samples
Download data: TXT
Series
Accession:
GSE49144
ID:
200049144
8.

Expression data from brain tissue of Rattus norvegicus treated with D-Serine

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS3643
Platform:
GPL1355
24 Samples
Download data: CEL
Series
Accession:
GSE10748
ID:
200010748
9.
Full record GDS3643

D-serine effect on the brain: dose response

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 6 dose sets
Platform:
GPL1355
Series:
GSE10748
24 Samples
Download data: CEL
DataSet
Accession:
GDS3643
ID:
3643
10.

Gene expression profiles in rat lung following intratracheal instillation with C60 fullerene particles

(Submitter supplied) Gene expression profiling of the rat lung following intratracheal instillation with C60 fullerene particles was employed to gain insights into these molecular events.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
22 Samples
Download data: TXT
Series
Accession:
GSE17747
ID:
200017747
11.

Gene expression profiles in rat lung after inhalation exposure to C60 fullerene or ultrafine NiO particles

(Submitter supplied) Gene expression profiling of the rat lung after whole-body inhalation exposure to C60 fullerene and ultrafine nickel oxide (Uf-NiO) particles as a positive control were employed to gain insights into these molecular events.
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL7294
6 Samples
Download data: TXT
Series
Accession:
GSE13249
ID:
200013249
12.

Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats

(Submitter supplied) Identification of molecular target(s) and mechanism(s) of silica-induced pulmonary toxicity is important for the intervention and/or prevention of diseases associated with occupational exposure to crystalline silica. Rats were exposed to crystalline silica by inhalation (15 mg/m3, 6 h/day, 5 days) and global gene expression profile was determined in the lungs by microarray analysis at 1, 2, 4, 8, and 16 weeks following termination of silica exposure. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
60 Samples
Download data: TXT
Series
Accession:
GSE32147
ID:
200032147
13.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Rattus norvegicus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6947 GPL6101
80 Samples
Download data
Series
Accession:
GSE30216
ID:
200030216
14.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 5)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30215
ID:
200030215
15.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 4)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30214
ID:
200030214
16.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 3)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30213
ID:
200030213
17.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 2)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
20 Samples
Download data: TXT
Series
Accession:
GSE30200
ID:
200030200
18.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (A549 cells dataset 1)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
10 Samples
Download data: TXT
Series
Accession:
GSE30180
ID:
200030180
19.

Mechanisms of crystalline silica-induced pulmonary toxicity revealed by global gene expression profiling (rat lungs)

(Submitter supplied) A proper understanding of the mechanisms underlying crystalline silica-induced pulmonary toxicity has implications in the management and potential prevention of the adverse health effects associated with silica exposure including silicosis, cancer and several auto-immune diseases. Human lung type II epithelial cells and rat lungs exposed to crystalline silica were employed as experimental models to determine global gene expression changes in order to understand the molecular mechanisms underlying silica-induced pulmonary toxicity. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6101
20 Samples
Download data: TXT
Series
Accession:
GSE30178
ID:
200030178
20.

Tobacco smoke exposure exacerbates silica-induced pulmonary toxicity in rats

(Submitter supplied) Previous studies have shown that smoking induces oxidative stress and inflammation, known factors that coincide with the development and progression of silicosis. Nevertheless, the precise role of cigarette smoke exposure in silicosis and the underlying mechanisms are not clearly understood. Therefore, the objective of the present study was to determine the effect of smoking, if any, on silica-induced pulmonary response and the underlying mechanisms. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
24 Samples
Download data: TXT
Series
Accession:
GSE136945
ID:
200136945
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