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Links from GEO DataSets

Items: 15

1.
Full record GDS5204

Age effect on normal adult brain: frontal cortical region

Analysis of postmortem neuropathologically normal brain samples from the frontal cortical regions of young, middle aged, normal aged and extremely aged adults. Results provide insight into molecular mechanisms of aging in frontal cortical regions of the brain.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 4 age, 2 gender sets
Platform:
GPL570
Series:
GSE53890
41 Samples
Download data: CEL
2.

REST and Stress Resistance in Aging and Alzheimer’s Disease

(Submitter supplied) Comparison of the gene expression profiles of adult human brain samples from frontal cortical regions, including samples from young, middle aged, normal aged.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5204
Platform:
GPL570
41 Samples
Download data: CEL
Series
Accession:
GSE53890
ID:
200053890
3.

Regulation of Lifespan by Neural Excitation and REST

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19757
24 Samples
Download data
Series
Accession:
GSE123146
ID:
200123146
4.

Regulation of Lifespan by Neural Excitation and REST [Day 10]

(Submitter supplied) Explore the effects of spr-4 and spr-3 on daf-2 function and lifespan.
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19757
12 Samples
Download data: TXT
Series
Accession:
GSE123145
ID:
200123145
5.

Regulation of Lifespan by Neural Excitation and REST [Day 2]

(Submitter supplied) Explore the effects of spr-4 and spr-3 on daf-2 function and lifespan.
Organism:
Caenorhabditis elegans
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19757
12 Samples
Download data: CSV
Series
Accession:
GSE107134
ID:
200107134
6.

Neuronal DNA damage response-associated dysregulation of signalling pathways and cholesterol metabolism at th earliest stages of Alzheimer-type pathology

(Submitter supplied) High levels of oxidative stress and an associated neuronal DDR occur at the earliest stages of Alzheimer pathology (low Braak stage), and is associated with cognitive impairment. The aim of the present study was to combine immuno-LCM and microarray analysis to characterize the neuronal transcriptome at low Braak stages (Braak 0-II), with respect to the neuronal DDR, in post-mortem human frontal cortex derived from the Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS).
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE66333
ID:
200066333
7.

Down syndrome study

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
9 Samples
Download data: GPR
Series
Accession:
GSE14105
ID:
200014105
8.

dyrk1a

(Submitter supplied) Transcription profiling of transgenic down syndrome mouse model to show the role of DYRK1A gene. The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7877
5 Samples
Download data: GPR
Series
Accession:
GSE14072
ID:
200014072
9.

Transcriptional analysis of murine neurobastoma N18 cell line transfected with a pAd-Dyrk1a vector

(Submitter supplied) The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. We found that DYRK1A binds the SWI/SNF-complex known to interact with REST/NRSF. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
5 Samples
Download data: GPR
Series
Accession:
GSE14030
ID:
200014030
10.

Transcriptional analysis of E12.5 telencephalon from 152F7 transgenic mouse

(Submitter supplied) The molecular mechanisms that lead to the cognitive defects characteristic of Down syndrome (DS), the most frequent cause of mental retardation, have remained elusive. Here we use a transgenic DS mouse model to show that DYRK1A gene dosage imbalance deregulates chromosomal clusters of genes located near neuron-restrictive silencer factor (REST/NRSF) binding sites. We found that DYRK1A binds the SWI/SNF-complex known to interact with REST/NRSF. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL2872
4 Samples
Download data: GPR
Series
Accession:
GSE14021
ID:
200014021
11.

REST and Neural Gene Network Dysregulation in iPS Cell Models of Alzheimer’s Disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing
Platforms:
GPL25371 GPL16791
37 Samples
Download data: CEL
Series
Accession:
GSE117589
ID:
200117589
12.

REST and Neural Gene Network Dysregulation in iPS Cell Models of Alzheimer’s Disease (RNA-seq data set)

(Submitter supplied) Alzheimer’s disease (AD) is preceded by a long prodromal period of decades during which pathology accumulates in the brain prior to the onset of dementia. The molecular basis of these changes as well as how and when they start are unclear. Here we have analyzed neural progenitor (NP) cells and neurons generated from induced pluripotent stem cells (iPSCs) from individuals with sporadic AD (AD) and age-matched controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
6 Samples
Download data: TSV
Series
Accession:
GSE117588
ID:
200117588
13.

REST and Neural Gene Network Dysregulation in iPS Cell Models of Alzheimer’s Disease (Affymetrix NPC data set)

(Submitter supplied) Alzheimer’s disease (AD) is preceded by a long prodromal period of decades during which pathology accumulates in the brain prior to the onset of dementia. The molecular basis of these changes as well as how and when they start are unclear. Here we have analyzed neural progenitor (NP) cells and neurons generated from induced pluripotent stem cells (iPSCs) from individuals with sporadic AD (AD) and age-matched controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL25371
10 Samples
Download data: CEL
Series
Accession:
GSE117586
ID:
200117586
14.

REST and Neural Gene Network Dysregulation in iPS Cell Models of Alzheimer’s Disease (Affymetrix neurons data set)

(Submitter supplied) Alzheimer’s disease (AD) is preceded by a long prodromal period of decades during which pathology accumulates in the brain prior to the onset of dementia. The molecular basis of these changes as well as how and when they start are unclear. Here we have analyzed neural progenitor (NP) cells and neurons generated from induced pluripotent stem cells (iPSCs) from individuals with sporadic AD (AD) and age-matched controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL25371
11 Samples
Download data: CEL
Series
Accession:
GSE117585
ID:
200117585
15.

REST and Neural Gene Network Dysregulation in iPS Cell Models of Alzheimer’s Disease (Affymetrix iPSC data set)

(Submitter supplied) Alzheimer’s disease (AD) is preceded by a long prodromal period of decades during which pathology accumulates in the brain prior to the onset of dementia. The molecular basis of these changes as well as how and when they start are unclear. Here we have analyzed neural progenitor (NP) cells and neurons generated from induced pluripotent stem cells (iPSCs) from individuals with sporadic AD (AD) and age-matched controls. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL25371
10 Samples
Download data: CEL
Series
Accession:
GSE117584
ID:
200117584
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