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Links from GEO DataSets

Items: 20

1.
Full record GDS5219

Histone methyltransferase MMSET overexpression effect on KMS11 multiple myeloma cell line

Analysis of KMS11 t(4;14) MM parental cell line with a normal overexpressed multiple myeloma SET domain containing protein (MMSET) and cell lines knocked out for MMSET on the translocated allele (TKO) or on the non-translocated allele (NTKO). Results provide insight into role of MMSET in t(4;14) MM.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 4 genotype/variation sets
Platform:
GPL6884
Series:
GSE57863
12 Samples
Download data
2.

MMSET Induces Global and Focal Changes in Histone Methylation in Myeloma Cells

(Submitter supplied) We investigated genome wide distribution of H3K36me2, H3K36me3 and H3K27me3 in the presence and absence of MMSET protein. MMSET overexpression in t(4;14)+ myeloma leads to global loss redistribution of H3K36me2 and genome-wide loss of H3K27 methylation. Despite the gloal decrease in H3K27me3, specific regions of the genome show enhanced H3K27me3 enrichment through increased recruitment of EZH2 methyltransferase
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
16 Samples
Download data: BW
Series
Accession:
GSE57977
ID:
200057977
3.

MMSET regulation of gene expression in t(4;14)+ myeloma

(Submitter supplied) We investigated gene expression in isogenic myeloma cell lines with or without overexpressed MMSET protein. MMSET is a histone methyltransferase which methylates lysine 36 on histone H3. Overexpression of MMSET in myeloma leads to a global increase in H3K36 methylation and concomitant decrease in H3K27 methylation. These global changes in histone methylation lead to altered gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5219
Platform:
GPL6884
12 Samples
Download data: TXT
Series
Accession:
GSE57863
ID:
200057863
4.

MMSET alters EZH2 Binding in Myeloma Cells

(Submitter supplied) We investigated EZH2 binding in the presence and absence of MMSET protein. MMSET overexpression in t(4;14)+ myeloma leads to global loss of H3K27 methylation and redistribution of EZH2 binding throughout the genome
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: TXT
Series
Accession:
GSE57632
ID:
200057632
5.

Treatment of multiple myeloma cells with EZH2 small molecule inhibitor

(Submitter supplied) We investigated differential gene expression in response to treatment of multiple myeloma cells with EZH2 inhibitor
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
8 Samples
Download data: TXT
Series
Accession:
GSE57478
ID:
200057478
6.

Effects of MMSET on gene expression in multiple myeloma

(Submitter supplied) The MMSET (Multiple Myeloma SET domain) protein is overexpressed in multiple myeloma patients with the translocation t(4;14). Although studies have shown the involvement of MMSET/WHSC1 in development, its mode of action in the pathogenesis of multiple myeloma (MM) is largely unknown. We found that MMSET is a major regulator of chromatin structure and transcription in t(4;14) MM cells. High levels of MMSET correlate with an increase in lysine 36 methylation of histone H3 and a decrease in lysine 27 methylation across the genome, leading to a more open structural state of the chromatin. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
18 Samples
Download data: TXT
Series
Accession:
GSE24746
ID:
200024746
7.

Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL4133 GPL9115
8 Samples
Download data: TXT
Series
Accession:
GSE41653
ID:
200041653
8.

Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer [ChIP-seq]

(Submitter supplied) Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here, we molecularly order two HMTases, EZH2 and MMSET that have established genetic links to oncogenesis. EZH2, which mediates histone H3K27 trimethylation and is associated with gene silencing, was shown to be coordinately expressed and function upstream of MMSET, which mediates H3K36 dimethylation and is associated with active transcription. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
2 Samples
Download data: TXT
Series
Accession:
GSE41652
ID:
200041652
9.

Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer [expression]

(Submitter supplied) Histone methyltransferases (HMTases), as chromatin modifiers, regulate the transcriptomic landscape in normal development as well in diseases such as cancer. Here, we molecularly order two HMTases, EZH2 and MMSET that have established genetic links to oncogenesis. EZH2, which mediates histone H3K27 trimethylation and is associated with gene silencing, was shown to be coordinately expressed and function upstream of MMSET, which mediates H3K36 dimethylation and is associated with active transcription. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
6 Samples
Download data: TXT
Series
Accession:
GSE41651
ID:
200041651
10.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL6885 GPL9115 GPL6947
25 Samples
Download data: TXT, WIG
Series
Accession:
GSE29305
ID:
200029305
11.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction]

(Submitter supplied) NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enzyme influences chromatin biology and myeloma pathogenesis. Here we show that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
4 Samples
Download data: TXT
Series
Accession:
GSE29150
ID:
200029150
12.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [TKO]

(Submitter supplied) NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enzyme influences chromatin biology and myeloma pathogenesis. Here we show that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
9 Samples
Download data: TXT
Series
Accession:
GSE29148
ID:
200029148
13.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi]

(Submitter supplied) NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enzyme influences chromatin biology and myeloma pathogenesis. Here we show that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6947
6 Samples
Download data: TXT
Series
Accession:
GSE29147
ID:
200029147
14.

NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP]

(Submitter supplied) NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in understanding how this enzyme influences chromatin biology and myeloma pathogenesis. Here we show that dimethylation of histone H3 at lysine 36 (H3K36me2) is the principal chromatin-regulatory activity of NSD2. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
6 Samples
Download data: TXT, WIG
Series
Accession:
GSE29146
ID:
200029146
15.

Epigenetic Control of Skeletal Development by the Histone Methyltransferase Ezh2

(Submitter supplied) Inhibition of H3K27 methyltransferase EZH2 enhances osteogenic commitment of human mesenchymal progenitors and Ezh2 inactivation in mouse calvarial cells induces a post-proliferative state concomitant with increased production of a bone-related mineralizing extra-cellular matrix.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL13112 GPL11154
19 Samples
Download data: TSV
Series
Accession:
GSE73075
ID:
200073075
16.

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL16558 GPL17586
22 Samples
Download data: BED, CEL, TAB
Series
Accession:
GSE69253
ID:
200069253
17.

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target [Affymetrix]

(Submitter supplied) in this study we define an epigenomic profile of PRC2 (H3K27me3 and bivalent) tragets in four newly diagnosed MM patients. Using Oncomine database we demonstarte that PRC2 targets are underexpressed with advanced ISS stages and correlated to poor outcome. Pharmacological inhibition of UNC1999 showed anti-myeloma potential in vitro by activating the expression genes related to apoptosis and cell differenatiation.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17586
6 Samples
Download data: CEL
Series
Accession:
GSE69251
ID:
200069251
18.

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target [Seq]

(Submitter supplied) Multiple myeloma (MM) is a hematopoietic malignancy characterised by the accumulation of neoplastic post-germinal centre, isotype-switched, long-lived plasma cell within the bone marrow. In genetic and clinical terms MM is highly heterogeneous and remains fatal. Here we present the first epigenomic map of MM derived from freshly isolated bone marrow plasma cells from four patients. Using ChIP- and RNA-sequencing we define a set of silent H3K27me3 targets, active genes bearing H3K4me3, and bivalent genes.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platform:
GPL16558
16 Samples
Download data: BED, TAB
Series
Accession:
GSE53215
ID:
200053215
19.

EZH1 and H3K27me3 ChIP-chip data from mouse embryonic stem cells

(Submitter supplied) Trimethylation on H3K27 (H3K27me3) mediated by Polycomb repressive complex 2 (PRC2) has been linked to embryonic stem cell (ESC) identity and pluripotency. EZH2, the catalytic subunit of PRC2, has been reported as the sole histone methyltransferase that methylates H3K27 and mediates transcriptional silencing. Analysis of Ezh2(-/-) ESCs suggests existence of an additional enzyme(s) catalyzing H3K27 methylation. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
7 related Platforms
28 Samples
Download data: CEL, TXT
Series
Accession:
GSE15388
ID:
200015388
20.

Expression data from mouse ES cells and various differentiated cell types

(Submitter supplied) We used microarrays to detail the role of Polycomb proteins including Ezh2 and Eed in maintaining ES cell identity and executing pluripotency. Keywords: cell type and time course
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
53 Samples
Download data: CEL
Series
Accession:
GSE12982
ID:
200012982
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