GEO DataSets

Analysis of spleen from C57BL/6 females infected with Plasmodium yoelii strains N67 and N67C which produce different levels of disease severity. Results provide insight into host innate response pathways corresponding to strain-specific disease phenotypes.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 infection sets

Platform:

GPL6885

Series:

GSE51329

18 Samples

Download data: TXT

(Submitter supplied) Malaria infection triggers vigorous host immune responses; however, the parasite ligands, host receptors and the signaling pathways responsible for these reactions remain unknown or controversial. Malaria parasites primarily reside within red blood cells (RBCs), thereby hiding themselves from direct contact and recognition by host immune cells. Host responses to malaria infection are very different from those elicited by bacterial and viral infections and the host receptors recognizing parasite ligands have been elusive. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5225

Platform:

GPL6885

18 Samples

Download data: TXT

(Submitter supplied) Erythrocyte binding-like (EBL) proteins are known to play an important role in malaria parasite invasion; however, any roles in regulating host immune responses remain unknown. Here we show that an amino acid substitution (C741Y) in the protein trafficking domain of Plasmodium yoelii EBL (PyEBL) changes host immune response and disease severity, but not invasion of red blood cells (RBCs) as suggested previously. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

11 Samples

Download data: XLSX

(Submitter supplied) Malaria is a disease with diverse symptoms depending on host immune status and pathogenicity of Plasmodium parasites. The continuous parasite growth within a host suggests mechanisms of immune evasion and/or inhibition. To identify pathways commonly inhibited by malaria infection, we infected C67BL/6 mice with four Plasmodium yoelii strains causing different disease phenotypes and 24 progeny of a genetic cross. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

102 Samples

Download data: TXT

(Submitter supplied) An invading pathogen will trigger specific host responses, which can be explored to identify genes functioning in pathogen recognition and elimination. Here we performed trans-species expression quantitative trait locus (ts-eQTL) analysis using genotypes of the Plasmodium yoelii malaria parasite and phenotypes of mouse gene expression. We significantly (LOD score≥3.0) linked 1,054 host genes to many parasite genetic loci. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

81 Samples

Download data: TXT

(Submitter supplied) Malaria infection induces complex and diverse immune responses, including impairment of dendritic cell (DC) function and immune suppression that may contribute to the low vaccination antibody titers to some antigens in endemic populations. To elucidate the mechanisms underlying host-parasite interaction, we performed a genetic screen during early Plasmodium yoelii infection and identified a large number of interacting host and parasite genes/loci after trans-species expression quantitative trait loci (Ts-eQTL) analysis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

69 Samples

Download data: TXT

(Submitter supplied) Microarray studies using synchronized Plasmodium falciparum parasites have revealed a ‘continuous cascade’ of gene expression. Reports vary regarding the stability in these transcriptional patterns in the presence of external stressors. Using Plasmodium yoelii 17X parasites replicating in vivo, we have examined differential gene expression in parasites isolated from individual mice, from independent infections, during ascending and peak parasitemia and in the presence and absence of host antibody responses. more...

Organism:

Plasmodium yoelii

Type:

Expression profiling by array

Platform:

GPL14125

15 Samples

Download data: TXT

(Submitter supplied) Microarray profiling of amplified total splenic RNA isolated from TLR9-, TLR7-, UNC93b1- or MYD88- deficient mice or their C57BL/6 controls 24h after mock infection or infection with Plasmodium chabaudi.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

40 Samples

Download data: TXT

(Submitter supplied) N6-Methyladenosine (m6A) modification has been found to play important roles in diverse pathogen infections and host responses, here we report host m6A mRNA transcriptome profiles regulated by the infections of two strains of malaria parasite Plasmodium yoelii (N67 and N67C). We showed that malaria infection can regulate host m6A mRNA modification and reprogram host m6A mRNA methylome by mediating corresponding m6A catalytic enzyme levels. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL21103

12 Samples

Download data: TXT