GEO DataSets

Analysis of rhombomere regions 3 to 5 from embryos lacking the homeobox protein Hoxa1. Hoxa1 is necessary for the development of the brainstem, inner ear and heart. Results identify the role of Hoxa1 during embryogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL7202

Series:

GSE25868

8 Samples

Download data: TXT

(Submitter supplied) To better understand the role of Hoxa1 during embryogenesis and gain insight to the transcriptional network controlled by this gene, we carried out a large-scale screening for Hoxa1 downstream targets by performing microarray analysis. Tissue from the rhombomere 3-5 region of wildtype and Hoxa1 null embryos, including neuroectoderm, mesoderm and otic ectoderm was microdissected at the peak of Hoxa1 expression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS5228

Platform:

GPL7202

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Xenopus laevis

Type:

Expression profiling by array

Platforms:

GPL1318 GPL10756

27 Samples

Download data: CEL

(Submitter supplied) Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among them, Pax3 and Zic1 are both necessary and sufficient to trigger a complete neural crest developmental program. more...

Organism:

Xenopus laevis

Type:

Expression profiling by array

Platform:

GPL1318

11 Samples

Download data: CEL

(Submitter supplied) Neural crest development is orchestrated by a complex and still poorly understood gene regulatory network. Premigratory neural crest is induced at the lateral border of the neural plate by the combined action of signaling molecules and transcription factors such as AP2, Gbx2, Pax3 and Zic1. Among them, Pax3 and Zic1 are both necessary and sufficient to trigger a complete neural crest developmental program. more...

Organism:

Xenopus laevis

Type:

Expression profiling by array

Platform:

GPL10756

16 Samples

Download data: CEL

(Submitter supplied) Background: The goal of this study was to determine the transcriptional consequences of norepinephrine transporter (NET) gene deletion in noradrenergic neuron differentiation. The norepinephrine transporter (NET) is the target of powerful mind-altering substances, such as tricyclic antidepressants and the drug of abuse, cocaine. NET function in adult noradrenergic neurons of the peripheral and central nervous systems is that of a scavenger that internalizes norepinephrine from the synaptic cleft. more...

Organism:

Mus musculus

Type:

Expression profiling by SAGE

Platform:

GPL1349

2 Samples

Download data

(Submitter supplied) Microarrays containing the Compgen/Sigma-Genosys XEBLIB96 oligo set (which represents about 12,500 unique genes) was used to identify 100 genes up-regulated more than 2-fold by hoxb1b in zebrafish embryos

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL13908

6 Samples

Download data: TXT

(Submitter supplied) The transcription factors Pax3 and Zic1 are among the earliest genes activated at the neural plate border. Pax3 and Zic1 in combination promote neural crest fate, while Zic1 alone regulate cranial placode progenitor formation. We used microarrays to identify the global repertoire of genes activated by these facors individually or in combination to gain insights into the molecular mechanisms underlying cell fate decision at the neural plate border.

Organism:

Xenopus laevis

Type:

Expression profiling by array

Platform:

GPL10756

20 Samples

Download data: CEL

(Submitter supplied) Several transcription factors are known to be expressed in discrete regions of the otic vesicle and Dlx5 is one of those that is expressed highly in the presumptive dorsal vestibular region. Mice lacking Dlx5 have vestibular defects. Specifically, they fail to form the endolymphatic duct (a defect visible as early as E10) as well as the anterior and posterior semi-circular canals. The lateral canal does form but is smaller, whereas the saccule, the utricle and the cochlea appear relatively normal. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4443 GDS4577

Platform:

GPL1261

12 Samples

Download data: CEL

Analysis of otic vesicle derived 2B1 cells overexpressing Dlx5. Dlx5 is a homeobox transcription factor that plays a key role in the development of many organ systems. Results provide insight into the role of Dlx5 in the regulation of early inner ear development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL1261

Series:

GSE22381

4 Samples

Download data: CEL

Analysis of otic vesicles from E10 and E10.5 embryos deficient for Dlx5. Dlx5 is a homeobox transcription factor that plays a key role in the development of many organ systems. Results provide insight into the role of Dlx5 in the regulation of early inner ear development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE22381

8 Samples

Download data: CEL

(Submitter supplied) Retinoic acid (RA), an active derivative of the liposoluble vitamin A (retinol), acts as an important signaling molecule during embryonic development, regulating phenomenons as diverse as anterior-posterior axial patterning, forebrain and optic vesicle development, specification of hindbrain rhombomeres, pharyngeal arches and second heart field, somitogenesis, and differentiation of spinal cord neurons. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4836

Platform:

GPL6246

18 Samples

Download data: CEL, CHP

Analysis of anterior and posterior brain regions from Retinaldehyde Dehydrogenase 2 null-mutant (Raldh2-/-) embryos, which are unable to synthesize retinoic acid (RA) from maternally-derived retinol. Results provide insight into the repertoire of RA-regulated genes in the developing embryo.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 development stage, 2 genotype/variation, 2 tissue sets

Platform:

GPL6246

Series:

GSE43578

18 Samples

Download data: CEL, CHP

(Submitter supplied) We found that, whereas Hoxb1 does not affect NMP specification per se, it promotes NMP survival through the upregulation of Fgf8 and other components of Fgf signaling as well as the repression of components of the apoptotic pathway. Additionally, it upregulates the expression of some, primarily anterior, Hox genes suggesting that it plays an active role in the early steps of AP specification. In hindbrain neural progenitors Hoxb1 synergizes with shh to repress the expression of dorsal markers, regulate the expression of ventral markers and direct the specification of facial branchiomotorneuron (FBM) - like progenitors. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

18 Samples

Download data: TSV

(Submitter supplied) In our recent study, we reported the function of phosphatase and tensin homolog (PTEN) during inner ear development. PTEN is necessary for neuronal maintenance, such as neuronal survival and accurate nerve innervations of hair cells. To better understand the genes and signaling networks related to auditory neuron maintenance, we examined the profiles of differentially expressed genes (DEGs) using microarray analysis in Pten-deficient mice at E14.5. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

6 Samples

Download data: TXT

(Submitter supplied) The purpose of the study is to evaluate out whether the pattern of expression over time is similar between cells from the CVG, NC, and OV cell types.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL18573

27 Samples

Download data: CSV

(Submitter supplied) Stem/progenitor cells of the inner ear can be isolated as so-called otospheres from differentiated cells using a sphere forming assay. Although recent studies have demonstrated the characteristics of otospheres to some extent, most of the features of these cells are unknown. We describe the findings of transcriptome analyses with a cDNA microarray of otospheres derived from the cochleae of the inner ears of neonatal mice in order to clarify the gene expression profile of otic stem/progenitor cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

11 Samples

Download data: TXT

(Submitter supplied) The study of the gene expression during otic development is a source of important information for understanding the mechanism of inner ear development and subsequently create appropriate gene therapies both to prevent hearing loss and eventually to regenerate the damaged parts.This dataset contains data from temporal expression profiles in an epithelial cell line derived from the cochlear duct of a mouse inner ear at embryonic day E10.5. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

6 Samples

Download data: CEL

(Submitter supplied) This study explores the profiles of genes expressed during conditional differentiation of inner ear hair cell precursors in vitro. The cell line UB/OC-1 was derived from mouse embryonic organs of Corti (Rivolta et al, Proc. R. Soc. Lond. B 265: 1595-1603, 1998) and it can be induced to differentiate upon a temperature shift. The study has been replicated in two separate populations of cells, named Exp A and Exp B. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS45 GDS51

Platforms:

GPL75 GPL76

32 Samples

Download data

Gene expression profile of differentiation of inner ear hair cell precursors in vitro. A conditionally immortal cell line derived from the mouse cochlea, UB/OC-1, examined from 0 to 14 days.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 12 time sets

Platform:

GPL76

Series:

GSE36

16 Samples

Download data