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Links from GEO DataSets

Items: 17

1.
Full record GDS5230

miR-193b overexpression effect on pancreatic cell line

Analysis of MIA PaCa-2 pancreatic cancer cells overexpressing miR-193b. Aberrant expression of microRNAs occurs in various cancers, including pancreatic cancer. Results identify target genes of miR-193b.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6480
Series:
GSE25215
4 Samples
Download data: TXT
DataSet
Accession:
GDS5230
ID:
5230
2.

Identification of target genes of miR-193b

(Submitter supplied) Searching of target genes of miR-193b by transcriptome assay using 44K Whole Human Genome Microarray system (Agilent Technologies, Palo Alto, CA) resulted in finding of several candidate genes.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5230
Platform:
GPL6480
4 Samples
Download data: TXT
Series
Accession:
GSE25215
ID:
200025215
3.

Pancreatic cancer vs. paired normal control

(Submitter supplied) The miRNA expression between normal and cancerous pancreatic tissues and identified preferentially expressed miRNAs.
Organism:
Rattus norvegicus; Murid gammaherpesvirus 4; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Homo sapiens; Human polyomavirus 1; Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
3 Samples
Download data: TXT
Series
Accession:
GSE28862
ID:
200028862
4.

The effect of miRNA overexpression on gene expression profile of MCF-7 cells

(Submitter supplied) To identify microRNAs impacting estrogen receptor ERα expression in breast cancer, we have screened ER-positive breast cancer cells with a library of pre-miRs, and systematically monitored the ERα expression by protein lysate microarrays. There was a significant enrichment of the in silico predicted ERα targeting microRNAs among the hits. The most potent pre-miRs miR-18a/b, miR-193b, miR-206, and miR-302c, were confirmed to directly target ERα and to repress estrogen-responsive genes. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6102
11 Samples
Download data: TXT
Series
Accession:
GSE14847
ID:
200014847
5.

Integration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Homo sapiens; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array; Expression profiling by array
Platforms:
GPL7723 GPL6480
12 Samples
Download data: TXT
Series
Accession:
GSE30822
ID:
200030822
6.

Integration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (mRNA dataset)

(Submitter supplied) BRCA1 deregulation is a frequent event in the pathogenesis of breast as well as other cancers. In addition to the DNA repair functions of BRCA1, it is involved in a wide range of cellular processes such as cell cycle, chromatin remodeling or transcription. However, the molecular events underlying BRCA1-associated tumorigenesis are still largely unknown. In order to deepen our understanding of BRCA1-associated tumorigenesis, we integrated data from mRNA and miRNA microarray experiments on the HCC1937 breast cancer cell line, and the isogenic HCC1937 stably expressing BRCA1, to obtain significant miRNA-mRNA relationships associated to the presence of the BRCA1 gene. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
6 Samples
Download data: TXT
Series
Accession:
GSE30821
ID:
200030821
7.

Integration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (miRNA dataset)

(Submitter supplied) Microarray‐based techniques are being used to obtain miRNA and gene expression signatures associated with different samples. In order to deepen our understanding of BRCA1-associated tumorigenesis, we integrated data from microarray experiments to obtain significant miRNA-mRNA relationships associated with the presence of the BRCA1 gene. We obtained significant miRNA-gene-pathway relationships underlying the array signatures. more...
Organism:
Rattus norvegicus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
6 Samples
Download data: TXT
Series
Accession:
GSE30763
ID:
200030763
8.

Aberrant microRNA expression in radiation-induced rat mammary cancer: the potential role of miR-194 overexpression in cancer cell proliferation.

(Submitter supplied) Aberrant expression of microRNAs (miRNAs) is frequently associated with a variety of cancers, including breast cancer. We and others have demonstrated that radiation-induced rat mammary cancer exhibits a characteristic gene expression profile and a random increase in aberrant DNA copy number; however, the role of aberrant miRNA expression is unclear. We performed a microarray analysis of frozen samples of eight mammary cancers induced by gamma-irradiation (2 Gy), eight spontaneous mammary cancers, and seven normal mammary samples. more...
Organism:
Rattus norvegicus
Type:
Non-coding RNA profiling by array
Platform:
GPL10344
23 Samples
Download data: TXT
Series
Accession:
GSE34119
ID:
200034119
9.

Analysis of the miRNA profile associated with c-Src-mediated transformation

(Submitter supplied) To address the molecular mechanisms underlying c-Src-mediated tumor progression, we previously developed a model system using Csk-deficient fibroblasts that can be transformed by wild-type c-Src. In this study, we applied this system for the analysis of the potential contribution of miRNA to c-Src-mediated transformation. Pair-wise significance analysis of the microarray indicated that seven miR genes were significantly upregulated and six miRNA genes were downregulated in c-Src-transformed cells with a P value below 0.01 and with a fold change over 2.0.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL9756
8 Samples
Download data: TXT
Series
Accession:
GSE23426
ID:
200023426
10.

miRNA expression profiling in tumor-associated BMDCs induced by mouse ovarian and colon tumor cells

(Submitter supplied) miRNA expression profiling in tumor-associated BMDCs induced by tumor cells 1D8 or CT-26 in comparison with those cultured in medium.
Organism:
Human alphaherpesvirus 1; Human gammaherpesvirus 4; Human gammaherpesvirus 8; Human polyomavirus 1; Macaca mulatta polyomavirus 1; Mus musculus; Rattus norvegicus; Murid betaherpesvirus 1; JC polyomavirus; Human immunodeficiency virus 1; Homo sapiens; Human betaherpesvirus 5
Type:
Non-coding RNA profiling by array
Platform:
GPL16352
3 Samples
Download data: TXT
Series
Accession:
GSE42722
ID:
200042722
11.

Identification of human miR-34a-responsive transcripts

(Submitter supplied) In order to examine the consequences of human miR-34a induction on the transcriptome, HCT116 cells (a colon cancer cell line) were infected with a retrovirus that produces miR-34a. Gene expression profiles were then monitored using Affymetrix microarrays. Affymetrix microarrays were used to examine the transcriptomes of HCT116 cells infected with an empty retroviral vector (pMSCV-PIG) or a retroviral vector that expresses human miR-34a. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2755
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE7754
ID:
200007754
12.
Full record GDS2755

miR-34 overexpression

Analysis of HCT116 cells overexpressing miR-34, a microRNA. miR-34 is commonly deleted in human cancers. Results provide insight into the function of miR-34.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE7754
4 Samples
Download data: CEL
13.

Differentially expressed genes between the miR-506-overexpressing AsPC-1 pancreatic cancer cell line (n=3) and its negative control (n=3)

(Submitter supplied) To identify additional miR-506 target genes and the mechanisms behind its tumor-suppressive effect, we performed global microarray analysis of mRNA expression in a miR-506-overexpressing AsPC-1 pancreatic cancer cell line and a negative control
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL13497
6 Samples
Download data: TXT
Series
Accession:
GSE76280
ID:
200076280
14.

miRNA expression profiles in the serum of diabetic cats

(Submitter supplied) BACKGROUND: MicroRNAs negatively regulate gene expression and play a pivotal role in the pathogenesis of human type 2 diabetes mellitus (T2DM). As the domestic cat presents a spontaneous animal model for human T2DM, the purpose of this study was to investigate whether microRNAs are detectable in feline serum and whether microRNA expression profiles differ between healthy and diabetic cats. METHODS: Total RNA was extracted from 400 µl serum of healthy lean (HL) and newly diagnosed diabetic (D) cats. more...
Organism:
Felis catus; Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL15426
15 Samples
Download data: TXT
Series
Accession:
GSE37177
ID:
200037177
15.

Chip-chip from HCT116 cells with YBX1

(Submitter supplied) YBX1 is a multifunctional protein involved in the control of transcription and translation. We identified YBX1 as an target of MEK/ERK signaling in colorectal cancer cell lines. We performed a ChIP-chip analysis of HCT116 cells to identify new potential target genes of YBX1.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL7694 GPL7695
2 Samples
Download data: TXT
Series
Accession:
GSE18337
ID:
200018337
16.

RAS signaling in colon carcinoma: Target gene deregulation and growth control through Y-box-binding protein 1

(Submitter supplied) The perturbation of the genetic program due to mutational activation of KRAS- or BRAF-mediated signal transduction is a prerequisite for the expression of neoplastic phenotypes; however, the mechanisms of cancer cell-specific transcriptional deregulation are poorly understood. We have analyzed the human colorectal cancer cell lines HCT116, HT29 and SW480 using an integrated approach combining transcriptional profiling, small molecule inhibitors targeting signaling pathway effectors, and computational prediction of regulatory elements in promoters of co-expressed genes with chromatin-based and cellular assays. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
18 Samples
Download data: CEL
Series
Accession:
GSE18232
ID:
200018232
17.

Expression data from CIC wild type and knockout cell lines

(Submitter supplied) Type I low-grade gliomas (LGGs), characterized by 1p/19q co-deletions and IDH1/2 mutations, show superior overall survival compared to other gliomas. Approximately 70% of cases harbour mutations in the Capicua (CIC) gene, whose product is a transcriptional repressor whose transcriptional network has yet to be extensively studied in human cells. To address this, we developed CIC knockout cell lines and used transcriptome analyses to study the consequences of CIC loss. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL
Series
Accession:
GSE80359
ID:
200080359
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