Similar studies for GEO DataSets (Select 5233) - GEO DataSets

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Items: 2

Select item 52331.

Bisphenol A effect on the fetal urogenital sinus: time course

Analysis of urogenital sinuses (UGS) of male fetuses exposed to bisphenol A. BPA is a ubiquitous, estrogenic chemical used in the production of polycarbonate plastics. UGS examined at embryonic days 17 and 18, and postnatal day 0. Results provide insight into the molecular effects of BPA on UGS.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 age, 3 agent sets

Platform:: GPL1261
Series:: GSE24928
9 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5233

ID:: 5233

Select item 2000249282.

Gene expression change induced by bisphenol A in mouse urogenital sinus

(Submitter supplied) Bisphenol A (BPA), an endocrine-disrupting chemical (EDC), is a well-known, ubiquitous estrogenic chemical. To investigate the effects of fetal exposure to low-dose BPA on the development of the prostate, we first examined the alterations of in situ sex steroid hormonal environment in the mouse urogenital sinus (UGS). Next, to investigate the BPA-specific gene alterations related to increases of the E2 levels and aromatase activity, we performed comprehensive gene expression analysis using Affymetrix GeneChip in the BPA-treated or DES-treated male UGS at embryonic day 17th and postnatal day 1st.