Similar studies for GEO DataSets (Select 5246) - GEO DataSets

Select item 52461.

Oligodendroglial cell model of multiple system atrophy: time course

Analysis of oligodendroglia stably expressing α-synuclein and transiently expressing p25α for up to 16 hrs. Coexpression of α -synuclein and p25α causes a degenerative phenotype modeling multiple system atrophy (MSA). Results provide insight into the molecular basis of MSA pathogenesis.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol, 3 time sets

Platform:: GPL1355
Series:: GSE51781
12 Samples

Download data: CEL

DataSet

Accession:: GDS5246

ID:: 5246

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000517812.

Expression data from oligodendroglial cell line

(Submitter supplied) Coexpression of alpha-synuclein and p25alpha in an oligodendroglial cell line elicites a degenerative response that relies on aggregation and phosphorylation of alpha-synuclein at Ser129 We used microarray analysis to detail the changes in gene expression caused by alpha-synuclein aggregation followed by cellular degeneration

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS5246
Platform:: GPL1355
12 Samples

Download data: CEL, XLS

Series

Accession:: GSE51781

ID:: 200051781

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001075823.

RNA-seq analysis for mRNA expression change in alpha-synclein fibril-treated cultured oligodendrocyte precursor cells

(Submitter supplied) Glial cytoplasmic inclusion is the pathological hallmark of multiple system atrophy commonly observed as alpha-synulcien-positive aggregates within oligodendrocytes. We elucidated that preformed alpha-synulcien fibrils triggers multimerization and upsurge of endogenous alpha-synulcien in oligodendrocyte precursor cells which is attributable to insufficient autophagic proteolysis. To assess the functional influence of alpha-synuclein fibrils application on oligodendrocyte precursor cells, RNA-seq analysis was performed. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19052
6 Samples

Download data: TXT

Series

Accession:: GSE107582

ID:: 200107582

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002285264.

Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression

(Submitter supplied) Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm to mediate immune response. We investigate the relationship between p65 and inhibitor-κB⍺ (IκBα) protein levels and dynamic properties of the system, and how this interaction impacts on the expression of key inflammatory genes. more...