Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS5254

Pirin depletion effect on myelomonocytic cell line

Analysis of U937 myelomonocytic cells depleted for Pirin. Pirin is silenced in cells with the acute myeloid leukemia-1 eight-twenty-one and promyelocytic leukemia/retinoic acid receptor leukemogenic fusion proteins. Results provide insight into the role of Pirin in myeloid differentiation.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL570
Series:
GSE16798
4 Samples
Download data: CEL
DataSet
Accession:
GDS5254
ID:
5254
2.

Genes regulated after knock-down of Pirin in U937 cells

(Submitter supplied) Pirin (PIR) is a putative transcriptional regulator whose expression is silenced in cells bearing the AML1/ETO and PML/RAR leukemogenic fusion proteins and is significantly repressed in a large proportion of acute myeloid leukemias. PIR expression increases during in vitro myeloid differentiation of primary hematopoietic precursor cells, and ablation of PIR in the U937 myelomonocytic cell line or in murine primary hematopoietic precursor cells results in impairment of terminal myeloid differentiation. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5254
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE16798
ID:
200016798
3.

Expression data of Wnt3a stimulated K562 cells after CXXC5 overexpression or knockdown

(Submitter supplied) CXXC5 inhibits the canonical Wnt signaling pathway Impact of CXXC5 on Wnt stimulated gene expression in K562 cells
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE67060
ID:
200067060
4.

POU4F1 is associated with t(8;21) AML and contributes directly to its unique transcriptional signature

(Submitter supplied) POU4F1 is associated with t(8;21) acute myeloid leukemia (AML) and contributes directly to its unique transcriptional signature
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4042
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE19997
ID:
200019997
5.
Full record GDS4042

Transcription factor POU4F1 effect on fetal liver cells

Analysis of fetal liver cells expressing high, wildtype, or null levels of the POU domain-containing transcription factor POU4F1. Dysregulation of POU4F1 is a recurring abnormality in t(8;21) human acute myeloid leukemia (AML). Results provide insight into the role of POU4F1 in t(8;21) AML.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE19997
9 Samples
Download data: CEL
6.

BCL6 mediates Chemoresistance in Acute Myeloid Leukemia

(Submitter supplied) BCL6 is a transcription repressor that plays a crucial role in germinal center formation and lymphomagenesis. However, its role in myeloid malignancies remains unclear. Here, we explored the role of BCL6 in acute myeloid leukemia (AML). Heterogeneous levels of BCL6 were found across AML cell lines and primary AML samples. Cells with higher levels of BCL6 were indeed sensitive to treatment with BCL6 inhibitors. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
9 Samples
Download data: TXT
Series
Accession:
GSE133112
ID:
200133112
7.

Expression data from pediatric AML patients

(Submitter supplied) Pediatric acute myeloid leukemia (AML) is a heterogeneous disease characterized by non-random genetic aberrations related to outcome. Detecting these aberrations however still lead to failures or false negative results. Therefore, we focused on the potential of gene expression profiles (GEP) to classify pediatric AML. Gene expression microarray data of 237 children with AML were generated and cases were split into a discovery cohort (n=157) and an independent validation cohort (n=80). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
237 Samples
Download data: CEL
Series
Accession:
GSE17855
ID:
200017855
8.

Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort)

(Submitter supplied) Childhood acute lymphoblastic leukemia (ALL) comprises a large group of genetic subtypes with a favorable prognosis characterized by a TEL-AML1-fusion, hyperdiploidy (>50 chromosomes) or E2A-PBX1 fusion and a smaller group with unfavorable outcome characterized by either a BCR-ABL-fusion, MLL-rearrangement or T-ALL. About 25% of precursor B-ALL are currently genetically unclassified and have an intermediate prognosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL96
190 Samples
Download data: CEL
Series
Accession:
GSE13425
ID:
200013425
9.

Expression data from ALL samples for patients included in the Dutch Childhood Oncology Group

(Submitter supplied) Childhood acute lymphoblastic leukemia (ALL) comprises a large group of genetic subtypes with a favorable prognosis characterized by a TEL-AML1-fusion, hyperdiploidy (>50 chromosomes) or E2A-PBX1 fusion and a smaller group with unfavorable outcome characterized by either a BCR-ABL-fusion, MLL-rearrangement or T-ALL. About 25% of precursor B-ALL are currently genetically unclassified and have an intermediate prognosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
107 Samples
Download data: CEL, CHP
Series
Accession:
GSE13351
ID:
200013351
10.

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL5082 GPL5811 GPL8321
49 Samples
Download data: BAR, BED, CEL
Series
Accession:
GSE12363
ID:
200012363
11.

Genome-wide analysis of H3K79 dimethylation in MLL-AF4 leukemic bone marrow

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). ChIP-chip analysis demonstrated increased histone H3 Lysine 79 (H3K79) dimethylation that correlated with Mll-AF4 associated gene expression profiles in murine ALLs, and in human MLL-rearranged leukemias. In addition, human MLL-rearranged ALLs can be distinguished from other ALLs by their genome-wide H3K79 methylation profiles. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL5811
1 Sample
Download data: BAR, BED, BPMAP, CEL
Series
Accession:
GSE12362
ID:
200012362
12.

Genome-wide analysis of H3K79 dimethylation in normal and MLL-AF4 leukemic pre-B cells

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). ChIP-chip analysis demonstrated increased histone H3 Lysine 79 (H3K79) dimethylation that correlated with Mll-AF4 associated gene expression profiles in murine ALLs, and in human MLL-rearranged leukemias. In addition, human MLL-rearranged ALLs can be distinguished from other ALLs by their genome-wide H3K79 methylation profiles. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL5811
2 Samples
Download data: BAR, BED, BPMAP, CEL
Series
Accession:
GSE12361
ID:
200012361
13.

Genome-wide analysis of H3K79 methylation in CD34+ CD19+ cells from normal marrow, MLL-rearranged or MLL-germline ALL

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). ChIP-chip analysis demonstrated increased histone H3 Lysine 79 (H3K79) dimethylation that correlated with Mll-AF4 associated gene expression profiles in murine ALLs, and in human MLL-rearranged leukemias. In addition, human MLL-rearranged ALLs can be distinguished from other ALLs by their genome-wide H3K79 methylation profiles. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platform:
GPL5082
3 Samples
Download data: BAR, BED, BPMAP, CEL
Series
Accession:
GSE12360
ID:
200012360
14.

Expression profiling of activated or control 5-FU bone marrow from MLL-AF4stop knockin mice

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE12313
ID:
200012313
15.

Expression profiling of normal murine lymphoid progenitors and MLL-AF4 leukemic lymphoblasts

(Submitter supplied) We created a mouse model where conditional expression of physiologic levels of an Mll-AF4 fusion oncogene induces development of acute lymphoblastic (ALL) or acute myeloid leukemias (AML). Immunophenotypic and gene expression analysis of the ALL cells demonstrated bone marrow replacement with B-precursor cells which express a gene expression profile that has significant overlap with profiles in human MLL-rearranged ALL. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
39 Samples
Download data: CEL
Series
Accession:
GSE12310
ID:
200012310
16.

Zinc finger protein 521 overexpression is a feature of MLL-rearranged acute myeloid leukemia and contributes to the maintenance of myeloid differentiation block

(Submitter supplied) ZNF521 is a multiple zinc finger transcription factor previously identified because abundantly and selectively expressed in normal CD34+ hematopoietic stem and progenitor cells. From microarray datasets, aberrant expression of ZNF521 has been reported in both pediatric and adult acute myeloid leukemia (AML) patients with MLL gene rearrangements. However, a proper validation of microarray data is lacking, likewise ZNF521 contribution in MLL-rearranged AML is still uncertain. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
6 Samples
Download data: CEL
Series
Accession:
GSE79110
ID:
200079110
17.

In Vitro Transformation of Primary Human CD34+ Cells by AML Fusion Oncogenes: Early Gene Expression Profiling Reveals Possible Drug Target in AML

(Submitter supplied) Different fusion oncogenes in acute myeloid leukemia (AML) have distinct clinical and laboratory features suggesting different modes of malignant transformation. Here we compare the in vitro effects of representatives of major groups of AML fusion oncogenes on primary human CD34+ cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5059
Platform:
GPL570
30 Samples
Download data: CEL
Series
Accession:
GSE57194
ID:
200057194
18.
Full record GDS5059

Acute myeloid leukemia fusion oncogenes in vitro effect on primary CD34+ cells: time course

Analysis of CD34+ cells nucleofected (6h) or transduced (3d, 8d) with AML leukemia fusion oncogenes: AML1-ETO, MLL-AF9, PML-RARA or NUP98-HOXA9. Results provide insight into molecular mechanisms of fusion oncogene-driven leukemogenesis and early temporal patterns of gene deregulation in AML.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 10 protocol, 3 time sets
Platform:
GPL570
Series:
GSE57194
30 Samples
Download data: CEL
19.

The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia

(Submitter supplied) Fusion proteins involving the ETS factor ERG have been associated with multiple cancers such as Ewing's sarcoma and prostate cancer. In acute myeloid leukemias harboring t(16;21) another ERG fusion protein is expressed, FUS-ERG. Here, we found that this FUS-ERG oncofusion protein acts in the context of a heptad of proteins (ERG, FLI1, GATA2, LYL1, LNMO2, RUNX1 and TAL1) central to proper expression of genes involved in maintaining a stem cell hematopoietic phenotype. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL11154 GPL10999
20 Samples
Download data: WIG
Series
Accession:
GSE60477
ID:
200060477
20.

Epigenetic regulation of the apoptosis program in t(8;21) AMLs by an AML1-ETO, ERG and RUNX1 triad

(Submitter supplied) The t(8;21) acute myeloid leukemia associated oncoprotein AML1-ETO is a transcription factor that aberrantly regulates the pathways that lead to myeloid differentiation. Here, we set out to investigate the effects of AML1-ETO on gene expression and the epigenome in patient blast cells. We identify two modules, one in which AML1-ETO binds promoter regions of active genes and one represented by non-promoter binding to accessible, yet inactive chromatin regions. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL10999 GPL11154
16 Samples
Download data: WIG
Series
Accession:
GSE76464
ID:
200076464
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=3|blobid=MCID_61516c455b083a67f5295fb5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center