GEO DataSets

Analysis of lungs of diabetic animals. Diabetes induced by streptozotocin treatment. Results provide insight into the impact of diabetes on the cellular and molecular processes in the lung.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE15900

12 Samples

Download data: CEL

(Submitter supplied) Effect of type 1 diabetes (induced by streptozotocin 60 mg/kg) on lung gene expression. Wistar rats, male. At age 8 weeks control rats got IP buffer, diabetic rats got streptozotocin. At age 12 weeks animals were anesthetized and lungs removed. RNA was extracted with Trizol, and gene expression array analysis was performed using Affymetrix RAE 230A microarrays according to the directions from the manufacturer. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS5255

Platform:

GPL341

12 Samples

Download data: CEL

(Submitter supplied) 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, diaphragm muscle obtained at age of 12 weeks (thus animals were diabetic for 4 weeks) Keywords: Disease state analysis (diabetes)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

6 Samples

Download data

(Submitter supplied) Type 2 diabetes differs from type 1 diabetes in its pathogenesis. Type 1 diabetic diaphragm has altered gene expression which includes lipid and carbohydrate metabolism, ubiquitination and oxidoreductase activity. The objectives of the present study were to assess respiratory muscle gene expression changes in type 2 diabetes and to determine whether they are greater for the diaphragm than an upper airway muscle. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL341

22 Samples

Download data: CEL, CHP

(Submitter supplied) 8 week old rats injected with streptozotocin or buffer alone at age of 8 weeks, heart obtained at 12 weeks (thus animals were diabetic for 4 weeks). Left vent of heart. Keywords: Disease state analysis (diabetes)

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3153

Platform:

GPL341

6 Samples

Download data: CEL

Analysis of heart left ventricles of diabetic animals. Diabetes induced by streptozotocin treatment. Results provide insight into the molecular mechanisms underlying diabetes-induced cardiac dysfunction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE6880

6 Samples

Download data: CEL

(Submitter supplied) There has been an incresing body of epidemiologic and biochemical evidence implying the role of cerebral insulin resistance in Alzheimer-type dementia. For a better understanding of the insulin effect on the central nervous system we performed microarray-based gene expression profiling in the hippocampus, striatum and prefrontal cortex of streptozotocin-induced and spontaneously diabetic Goto-Kakizaki rats as model animals for type 1 and type 2 diabetes, respectively. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL15011

27 Samples

Download data: TXT

(Submitter supplied) Gene expression analysis in control and diabetic rats. Diabetes-induced erectile dysfunction in rat model of DM. 10 weeks of streptozotocin induced diabetes. F344 Rats. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1393

Platform:

GPL341

10 Samples

Download data: CEL, EXP, RPT

Analysis of F344 penile cavernosal tissue after 10 weeks of streptozotocin (STZ)-induced Type 1 diabetes. Results provide insight into molecular events associated with pathophysiology of diabetes-induced erectile dysfunction (ED).

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL341

Series:

GSE2457

10 Samples

Download data: CEL, EXP, RPT

(Submitter supplied) RNA was obtained from rear leg muscle of normal and diabetic rats in the presence and absence of oral treatment with vandyl sulfate. Diabetes was induced with streptozotocin and expression profiles were determined using Affymetrix Rat Genechip U34A. The effect of treatment and disease on gene expression was examined. Keywords: vanadium treatment

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1913

Platform:

GPL85

20 Samples

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Expression profiling of rear leg muscles of diabetic Wistars treated with vanadyl sulfate. Diabetes induced with streptozotocin (STZ). Studies show that vanadyl sulfate relieves diabetic hyperglycemia.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 2 disease state sets

Platform:

GPL85

Series:

GSE3068

20 Samples

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(Submitter supplied) Gene expression profiles in tissues of Zucker diabetic fatty (ZDF) rats compared with age matched Zucker lean control (ZLC) rats. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1767

Platform:

GPL1002

24 Samples

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Analysis of adipose, skeletal muscle, and liver tissues of Zucker diabetic fatty animals at pre-diabetic and diabetic stages. ZDF animals have a mutated leptin receptor. Results provide insight into the molecular mechanisms responsible for insulin resistance and progression to type 2 diabetes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log ratio, 2 age, 3 tissue sets

Platform:

GPL1002

Series:

GSE1080

24 Samples

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