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Links from GEO DataSets

Items: 20

1.
Full record GDS5256

Caveolin-1 deficiency effect on dexamethasone treatment: embryonic day E14.5 cerebral cortex

Analysis of E14.5 cerebral cortex, Caveolin-1 (Cav-1) deficient, cultured neurospheres treated with glucocorticoid (GC) dexamethasone (100nM, 4h). Cav-1 involved in GC signaling in neural stem cells. Results provide insight into role of Cav-1 in GC treatment and impact fetal brain development.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL8321
Series:
GSE49804
20 Samples
Download data: CEL
2.

Expression data from dexamethasone treated mouse embryonic neural progenitor/stem cells isolated from wild type C57Bl/6 or caveolin-1 knockout mice

(Submitter supplied) Neurosphere cultures prepared from E14.5 mouse cerebral cortex at passage 3 were treated for 4 hours with 100 nM dexamethasone We used microarrays to detail the global program of dexamethasone regulated gene expression in embryonic neural progenitor/stem cells
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5256
Platform:
GPL8321
20 Samples
Download data: CEL
Series
Accession:
GSE49804
ID:
200049804
3.

A Comparison of the Sexually Dimorphic Dexamethasone Transcriptome in Mouse Cerebral Cortical and Hypothalamic Embryonic Neural Stem Cells

(Submitter supplied) We used RNA-Seq analysis to identify the sexually dimorphic dexamethasone regulated gene expression profile in primary mouse embryonic cerebral cortical and hypothalamic neural progenitor/stem cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
24 Samples
Download data: XLSX
Series
Accession:
GSE95363
ID:
200095363
4.

Expression data from dexamethasone treated mouse embryonic hypothalamic progenitor/stem cells isolated from wild type C57Bl/6 male or female mice

(Submitter supplied) We used RNA-Seq to detail the global program of sexually dimorphic dexamethasone regulated gene expression in embryonic hypothalamic neural progenitor/stem cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: TXT
Series
Accession:
GSE55113
ID:
200055113
5.

Glycogen Synthase Kinase-3-beta Regulates Glucocorticoid Signaling by Phosphorylating the Glucocorticoid Receptor

(Submitter supplied) Glucocorticoids (GCs) bind to the glucocorticoid receptor (GR) to regulate diverse biological functions from cell growth to apoptosis. Drugs that mimic their action are the most commonly prescribed therapeutic agents in the world and are currently used for the treatment of many diseases including asthma, autoimmune disorders, and some cancers. However, the mechanisms by which one hormone, via one receptor, modulates such diverse biological functions remain unclear. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
12 Samples
Download data: TIFF, TXT
Series
Accession:
GSE11205
ID:
200011205
6.

C/EBP Maintains Chromatin Accessibility in Liver and Facilitates Glucocorticoid Receptor Recruitment to Steroid Response Elements

(Submitter supplied) DNase-seq and ChIP-seq determine that C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9185
32 Samples
Download data: TXT, XLSX
Series
Accession:
GSE46047
ID:
200046047
7.

Role of Serine 134 phosphorylation of the glucocorticoid receptor (GR) in glucocorticoid signaling

(Submitter supplied) In response to environmental stressors and a variety of inflammatory cytokines, p38 MAPKs become directly activated. Here we report the human glucocorticoid receptor (GR) Serine 134 as a novel target for p38 MAPK. Unlike most other phosphorylation events that occur on the GR, phosphorylation of Ser134 was found to be hormone-independent in several human and rat cell types. Instead we found phosphorylation of Ser134 was induced by a variety of stress-activating stimuli, including: glucose starvation, ultraviolet irradiation, osmotic shock, and oxidative stress. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
12 Samples
Download data: TXT
Series
Accession:
GSE28912
ID:
200028912
8.

Gene Regulation by the Human Glucocorticoid Receptor Dimerization Domain Mutant dim4

(Submitter supplied) A mutation in the dimerization domain of the mouse glucocorticoid receptor (GR), dim1, has recently been shown to bind DNA and regulate gene expression. To expand these studies we created a stable osteosarcoma (U-2 OS) cell line expressing four mutations in the dimerization domain of the human GR, dim4 (N454D, A458T, R460D, D462C), and used whole human genome microarray analysis to compare differences in gene regulation between vehicle treated (CON) and those treated with the glucocorticoid receptor agonist dexamethasone (DEX) at 100nM concentration for 6 hours.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4133
6 Samples
Download data: TXT
Series
Accession:
GSE26857
ID:
200026857
9.

Time course of glucocortiocid receptor isoforms

(Submitter supplied) Glucocorticoids regulate diverse physiologic processes and synthetic derivatives of these natural hormones are widely used in the treatment of inflammatory diseases. However, chronic administration often triggers insensitivity and serious side effects including osteoporosis. The underlying mechanisms regulating these side effects are not completely understood. We report here that human osteosarcoma U-2 OS bone cells lacking the glucocorticoid receptor (GR) are resistant to glucocorticoid killing whereas the expression of wild-type GR activates an apoptotic program. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3432
Platform:
GPL1708
60 Samples
Download data: TIFF, TXT
Series
Accession:
GSE6711
ID:
200006711
10.
Full record GDS3432

Osteosarcoma cell line response to activation of specific glucocorticoid receptor alpha isoforms: time course

Analysis of glucocorticoid receptor alpha (hGRalpha) isoform -A, -B, -C, or -D expressing osteosarcoma cells for up to 24 h after hGRalpha activation with dexomethasone. Cell apoptosis occurred in a GR isoform-selective manner. Results provide insight into the function of each isoform.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 5 agent, 4 time sets
Platform:
GPL1708
Series:
GSE6711
60 Samples
Download data: TIFF, TXT
11.

GR and Klf15 regulate gene expression dynamics and integrate signals through feed forward circuitry

(Submitter supplied) The glucocorticoid receptor (GR) regulates adaptive transcriptional programs that alter metabolism in response to stress. Network properties that allow GR to tune gene expression to match specific physiologic demands are poorly understood. We analyzed the transcriptional consequences of GR activation in murine lungs deficient for Klf15, a transcriptional regulator of amino acid metabolism that is induced by glucocorticoids and fasting
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
29 Samples
Download data: TXT
Series
Accession:
GSE44695
ID:
200044695
12.

Glucocorticoid receptor (GR) target genes in C2C12 myotubes

(Submitter supplied) Analysis of C2C12 myotubes treated with dexamethasone (Dex) for 6 or 24 hours. Dex is a synthetic glucorticoid receptor agonist. Results provide insight to the effect of glucocorticoids on myotubes.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
18 Samples
Download data
Series
Accession:
GSE28840
ID:
200028840
13.

Expression microarray screen for genes regulated by the unliganded glucocorticoid receptor

(Submitter supplied) To further characterize the role of the unliganded glucocorticoid receptor (GR) in breast cells, we used an shRNA vector directed against GR to create EPH-4 mouse mammary cell lines with depleted endogenous levels of this receptor. RNA prepared from normal (EV-50) and GR-depleted (shGR-19) cells was used in an expression microarray screen for targets of unliganded GR. This analysis revealed 260 targets of negaive regulation by unliganded GR, and 343 targets of positive regulation by unliganded GR, several of which were involved in pro-apoptotic networks, and opposed the activity of liganded GR targets. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
4 Samples
Download data: TXT
Series
Accession:
GSE51408
ID:
200051408
14.

Time course microarray data following GR activation in MCF10A-Myc breast cells

(Submitter supplied) This series contain time course microarray data from MCF10A-Myc cells treated with either ethanol or Dexamethasone for 30 min, 2 hr, 4 hr, and 24 hr. This series contains three biological replicates that were analyzed as independent replicate experiments (data were normalized within each replicate experiment, not across all samples). Keywords: time course
Organism:
Homo sapiens
Type:
Expression profiling by array
Datasets:
GDS2095 GDS2096 GDS2097
Platform:
GPL96
24 Samples
Download data: CEL
Series
Accession:
GSE4917
ID:
200004917
15.
Full record GDS2097

Glucocorticoid receptor activation effect on breast cancer cells: time course (series 3)

Analysis of breast cancer MCF10A-Myc cells at various time points up to 24 hours following treatment with dexamethasone to activate the glucocorticoid receptor (GR). GR activation is critical in the stress response of virtually all cell types.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL96
Series:
GSE4917
8 Samples
Download data: CEL
DataSet
Accession:
GDS2097
ID:
2097
16.
Full record GDS2096

Glucocorticoid receptor activation effect on breast cancer cells: time course (series 2)

Analysis of breast cancer MCF10A-Myc cells at various time points up to 24 hours following treatment with dexamethasone to activate the glucocorticoid receptor (GR). GR activation is critical in the stress response of virtually all cell types.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL96
Series:
GSE4917
8 Samples
Download data: CEL
DataSet
Accession:
GDS2096
ID:
2096
17.
Full record GDS2095

Glucocorticoid receptor activation effect on breast cancer cells: time course (series 1)

Analysis of breast cancer MCF10A-Myc cells at various time points up to 24 hours following treatment with dexamethasone to activate the glucocorticoid receptor (GR). GR activation is critical in the stress response of virtually all cell types.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 4 time sets
Platform:
GPL96
Series:
GSE4917
8 Samples
Download data: CEL
DataSet
Accession:
GDS2095
ID:
2095
18.

SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL10558 GPL11154
35 Samples
Download data: BED
Series
Accession:
GSE48379
ID:
200048379
19.

SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (ChIP-seq)

(Submitter supplied) In addition to the glucocorticoids, the glucocorticoid receptor (GR) is regulated by post-translational modifications, including SUMOylation. We have analyzed how SUMOylation influences the activity of endogenous GR target genes and the receptor chromatin binding by using isogenic HEK293 cells expressing wild-type GR (wtGR) or SUMOylation-defective GR (GR3KR). Gene expression profiling revealed that both dexamethasone up- and down-regulated genes are affected by the GR sumoylation and that the affected genes are significantly associated with pathways of cellular proliferation and survival. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
11 Samples
Download data: BED
Series
Accession:
GSE48374
ID:
200048374
20.

SUMOylation Regulates the Anti-Proliferative Gene Signature Programs of Glucocorticoid Receptor (U2Os cell line)

(Submitter supplied) In addition to the glucocorticoids, the glucocorticoid receptor (GR) is regulated by post-translational modifications, including SUMOylation. We have analyzed how SUMOylation influences the activity of endogenous GR target genes and the receptor chromatin binding by using isogenic HEK293 cells expressing wild-type GR (wtGR) or SUMOylation-defective GR (GR3KR). Gene expression profiling revealed that both dexamethasone up- and down-regulated genes are affected by the GR sumoylation and that the affected genes are significantly associated with pathways of cellular proliferation and survival. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
12 Samples
Download data: TXT
Series
Accession:
GSE48330
ID:
200048330
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