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Items: 2

1.
Full record GDS5278

Endometrium response to tamoxifen and low dose estradiol combination therapy

Analysis of endometria of postmenopausal cynomolgus macaques treated with tamoxifen and low dose estradiol. Tamoxifen is a selective estrogen receptor modulator (SERM). Estrogen and SERM co-therapy is an alternative to estrogen and progestin, a treatment associated with increased breast cancer risk.
Organism:
Macaca fascicularis; Macaca mulatta
Type:
Expression profiling by array, count, 4 agent sets
Platform:
GPL3535
Series:
GSE14518
16 Samples
Download data: CEL, CHP
2.

Endometrial profile of low-dose estradiol and tamoxifen combination therapy

(Submitter supplied) Combination therapy with estrogen and a selective estrogen receptor modulator (SERM) is a promising approach to safely alleviate important side effects related to estrogen deficiency in women at high risk for breast cancer. Data related to endometrial safety of estrogen+SERM co-therapies are limited, however. The primary goal of this study was to evaluate the endometrial profile of low-dose E2 and Tam alone and in combination.
Organism:
Macaca fascicularis; Macaca mulatta
Type:
Expression profiling by array
Dataset:
GDS5278
Platform:
GPL3535
16 Samples
Download data: CEL, CHP
Series
Accession:
GSE14518
ID:
200014518

Supplemental Content

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