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Items: 20

1.
Full record GDS5283

Hexahydro-1,3,5-trinitro-1,3,5-triazine effect on the liver: dose response and time course

Analysis of livers of males for up to 48 hours after treatment with a single, oral, nonseizure-inducing dose of 3 or 18 mg/kg hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is a synthetic, high-impact, stable explosive. Results provide insight into the acute effects of RDX on the liver.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 dose, 4 time sets
Platform:
GPL1355
Series:
GSE12196
24 Samples
Download data: CEL
DataSet
Accession:
GDS5283
ID:
5283
2.

Rat exposure to RDX (3mg/kg or 18mg/kg; 0, 4, 24, 48 hr)

(Submitter supplied) RDX (Hexahydro-1,3,5-trinitro-1,3,5-triazine) is a synthetic, high-impact, relatively stable explosive that has been in use since WWII. Exposure to RDX can occur either occupationally or through ordnance that lays unexploded on training ranges. The toxicology of RDX is dominated by acute tonic-clonic seizures at high doses, which remit when exposure is removed and internal RDX levels decrease. Sub-chronic studies have revealed few other toxic effects. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS5282 GDS5283
Platform:
GPL1355
48 Samples
Download data: CEL
Series
Accession:
GSE12196
ID:
200012196
3.
Full record GDS5282

Hexahydro-1,3,5-trinitro-1,3,5-triazine effect on the brain: dose response and time course

Analysis of cerebral cortices of males for up to 48 hours after treatment with an oral, nonseizure-inducing dose of 3 or 18 mg/kg hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX). RDX is a synthetic, high-impact, stable explosive. Results provide insight into the acute effects of RDX on the brain.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 2 dose, 4 time sets
Platform:
GPL1355
Series:
GSE12196
24 Samples
Download data: CEL
DataSet
Accession:
GDS5282
ID:
5282
4.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 7 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
24 Samples
Download data: TXT
Series
Accession:
GSE33935
ID:
200033935
5.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 6 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
8 Samples
Download data: TXT
Series
Accession:
GSE33934
ID:
200033934
6.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 5 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
8 Samples
Download data: TXT
Series
Accession:
GSE33932
ID:
200033932
7.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 4 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
24 Samples
Download data: TXT
Series
Accession:
GSE33928
ID:
200033928
8.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 3 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
24 Samples
Download data: TXT
Series
Accession:
GSE33919
ID:
200033919
9.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 2 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
11 Samples
Download data: TXT
Series
Accession:
GSE33893
ID:
200033893
10.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus) (part 1 of 10)

(Submitter supplied) Munitions constituents (MCs) including hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), 2,4,6-trinitrotoluene (TNT), and TNT derivatives are recognized to elicit aberrant neuromuscular responses in many species. The onset of seizures resulting in death was observed in the avian model Northern bobwhite after oral dosing with RDX beginning at 8 mg/kg/day in subacute (14 days) exposures, whereas affective doses of the TNT derivative, 2,6-dinitrotoluene (2,6-DNT), caused gastrointestinal impacts, lethargy, and emaciation in subacute and subchronic (60 days) exposures. more...
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
11 Samples
Download data: TXT
Series
Accession:
GSE33888
ID:
200033888
11.

Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Colinus virginianus
Type:
Expression profiling by array
Platform:
GPL14917
110 Samples
Download data: TXT
Series
Accession:
GSE27653
ID:
200027653
12.

Profiling differentially expressed earthworm genes in response to TNT, RDX, or TNT+RDX exposure.

(Submitter supplied) To understand molecular mechanisms of the joint effects of 2,4,6-trinitrotoluene (TNT) and hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX), both widely used ordnance compounds, we constructed a microarray consisting of 4,032 cDNA isolated from the earthworm Eisenia fetida using the suppressive subtractive hybridization technique. Worms were exposed to TNT-, RDX-, or TNT+RDX-spiked soil for 28 days (TNT 50 mg/kg, RDX 30 mg/kg). more...
Organism:
Eisenia fetida
Type:
Expression profiling by array
Platform:
GPL5776
40 Samples
Download data: TIFF
Series
Accession:
GSE8909
ID:
200008909
13.

Gene Expression Profiling of Rat Hippocampus Following Exposure to the Acetylcholinesterase Inhibitor Soman

(Submitter supplied) Soman (O-Pinacolyl methylphosphonofluoridate) is a potent neurotoxicant. Acute exposure to soman causes profound inhibition of the critical enzyme acetylcholinesterase, resulting in excessive levels of the neurotransmitter acetylcholine. Excessive acetylcholine levels cause convulsions, seizures, and respiratory distress. The initial cholinergic crisis can be overcome by rapid anti-cholinergic therapeutic intervention, resulting in increased survival. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS4940
Platform:
GPL1355
38 Samples
Download data: CEL
Series
Accession:
GSE13428
ID:
200013428
14.
Full record GDS4940

Hippocampus response to acetylcholinesterase inhibitor soman: time course

Analysis of hippocampi of Sprauge-Dawley males for up to 168 hours following exposure to the acetylcholinesterase inhibitor soman. Soman is a potent neurotoxicant. Results provide insight into the molecular pathogenesis of soman-induced neurodegeneration.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, transformed count, 3 agent, 10 time sets
Platform:
GPL1355
Series:
GSE13428
38 Samples
Download data: CEL
DataSet
Accession:
GDS4940
ID:
4940
15.

Differential gene expression in mice liver following primaquine administration

(Submitter supplied) Global gene expression in livers of primaquine treated mice was compared with control mice at different time points. Keywords: Time course
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL4389 GPL3493
7 Samples
Download data: TXT
Series
Accession:
GSE5979
ID:
200005979
16.

Comparison of genomic, morphological, and behavioral responses among fathead minnow (Pimephales promelas ) and zebrafish (Danio rerio) to acute RDX exposure

(Submitter supplied) Paper Abstract. Extrapolating toxicological sensitivity information across species can require the use of highly conservative safety factors as prescribed by ecological risk assessment protocols. The objective of our study was to use multipule factors to understand the dynamics of stress responses by comparing ecotoxicological, developmental, and genomic data to quantitatively determine the relative sensitivity of two common model aquatic vertebrates to assess the potential for developing refined safety factors among species. more...
Organism:
Danio rerio; Pimephales promelas
Type:
Expression profiling by array
Platforms:
GPL7301 GPL10259
59 Samples
Download data: TXT
Series
Accession:
GSE27067
ID:
200027067
17.

PGA Rat Liver Methylprednisolone

(Submitter supplied) Summary: The liver is the major site of gluconeogenesis, fat processing and distribution, as well as drug and xenobiotic metabolism. Altered gene expression in the liver is centrally invovled in both the immuosuppressive and the energetic actions of corticosteroids. Hypothesis: That pharmacodynamics can be derived from expression profiling data. Specific Aim: The aim of this project is to identify distinct temporal patters of RNA expression in the liver of rats following a bolus dose of the corticosteroid methylprednisolone. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Datasets:
GDS253 GDS972
Platforms:
GPL341 GPL85
91 Samples
Download data: CEL
Series
Accession:
GSE487
ID:
200000487
18.
Full record GDS972

Methylprednisolone effect on liver: time course (RAE230A)

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 168 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 11 time sets
Platform:
GPL341
Series:
GSE487
44 Samples
Download data: CEL
19.
Full record GDS253

Methylprednisolone effect on liver: time course

Expression profiling of liver from animals treated with methylprednisolone. Liver examined at various time points up to 72 hours following methylprednisolone treatment. Results provide insight into prednisone pharmacodynamics.
Organism:
Rattus norvegicus
Type:
Expression profiling by array, count, 2 agent, 17 time sets
Platform:
GPL85
Series:
GSE487
46 Samples
Download data: CEL
20.

Effect of Isoflurane and LTM on basolateral amygdala

(Submitter supplied) Fear conditioning in rats leads to long term memory (LTM) formation. A central neural substrate for LTM is the basolateral amygdala. We sought the expression changes specific to LTM at 6h following anesthesia with isoflurane (a general anesthetic and an effective amnestic agent), following pain (a component of conditioning), and following conditioning in presence and absence of isoflurane. Keywords = anesthesia, amygdala, LTM, Rampil, Isoflurane, fear, memory Keywords: other
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Dataset:
GDS2037
Platform:
GPL341
29 Samples
Download data
Series
Accession:
GSE1779
ID:
200001779
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