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Links from GEO DataSets

Items: 15

1.
Full record GDS5286

Monocyte-derived dendritic cells from young and aged donors

Comparison of dendritic cells (DCs) from young (20 to 27 years) and aged (77 to 87 years) donors. DCs are antigen-presenting cells important in initiating and regulating innate and adaptive immune responses. Results provide insight into the molecular basis of the decline in DC function with age.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL571
Series:
GSE58015
9 Samples
Download data: CEL
2.

Gene Expression Data in Human Monocyte-derived Dendritic Cell (MoDC) from Young and Aged Donors

(Submitter supplied) Dendritic cells (DCs) are major antigen-presenting cells that play a key role in initiating and regulating innate and adaptive immune responses. DCs are critical mediators of tolerance and immunity. The functional properties of DCs changes with age. The purpose of this study was to define the age-associated molecular changes in DCs by gene array analysis using Affymatrix GeneChips. We identified up and down-regulated gene expression changes in DC from aged donors compared to young donors.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5286
Platform:
GPL571
9 Samples
Download data: CEL
Series
Accession:
GSE58015
ID:
200058015
3.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL10333 GPL4134
6 Samples
Download data: GPR, TXT
Series
Accession:
GSE39863
ID:
200039863
4.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [A]

(Submitter supplied) T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific activation process, triggered by specialized dendritic cells (DCs), by which naive CD4+ Th0 cells acquire the capacity to produce Th2 cytokines. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
4 Samples
Download data: GPR
Series
Accession:
GSE39862
ID:
200039862
5.

Role of interleukin-4 in the licensing of dendritic cells for the induction of Th2 responses [B]

(Submitter supplied) T helper type 2 (Th2) responses are crucial for defense against infections by helminths and are responsible for the development of allergic reactions that can lead to severe clinical disorders, such as asthma or anaphylaxis, and ultimately to death. The induction of Th2 responses requires a specific activation process, triggered by specialized dendritic cells (DCs), by which naive CD4+ Th0 cells acquire the capacity to produce Th2 cytokines. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10333
2 Samples
Download data: TXT
Series
Accession:
GSE39858
ID:
200039858
6.

Expression data from human monocyte derived dendritic cells infected with adenovirus expressing HIV-1 Vpr

(Submitter supplied) HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune responses. We used the microarray analysis to elucidate the differnetail expression pattern of differnet genes in human dendritic cells infected with HIV-1 Vpr. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE61171
ID:
200061171
7.

Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors

(Submitter supplied) Attenuated poxviruses are safe and capable to express foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune response. This manuscript describes two strategies aimed to improve the immunogenicity of the highly attenuated, host-range restricted poxvirus NYVAC: deletion of the viral gene encoding type-I interferon-binding protein and development of attenuated replication-competent NYVAC. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6883 GPL6104
80 Samples
Download data: TXT
Series
Accession:
GSE26239
ID:
200026239
8.

Lactobacillus acidophilus induces virus immune defense genes in murine dendritic cells by a TLR-2 dependent mechanism

(Submitter supplied) Lactobacilli are probiotics that, among other health promoting effects, have been ascribed immunostimulating and virus preventive properties. Certain lactobacilli species have been shown to possess strong IL-12 inducing properties. As IL-12 production depends on the up-regulation of type I interferons, we hypothesized that the strong IL-12 inducing capacity of L. acidophilus NCFM in murine bone marrow derived DC is caused by an up-regulation of IFN-β, which subsequently stimulates the induction of IL-12 and the dsRNA binding toll like receptor (TLR)-3. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
16 Samples
Download data: CEL
Series
Accession:
GSE18460
ID:
200018460
9.

Measles Virus-Infected Dendritic Cells

(Submitter supplied) Human CD14+ monocytes were isolated and grown in GM-CSF and IL-4 for six days. The cells were then infected with measles virus, Chicago-1 strain, and RNA was isolated at 3, 6, 12, and 24 hours post-infection. Keywords: time-course
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS1681
Platform:
GPL8300
14 Samples
Download data: CEL
Series
Accession:
GSE980
ID:
200000980
10.
Full record GDS1681

Dendritic cell response to measles virus infection: time course

Analysis of dendritic cells (DCs) for up to 24 hours after infection with measles virus (MV). MV induces immunosuppression followed by lasting immunity. DCs appear to play a role in this effect. Results provide insight into MV-DC interactions and suggest mechanisms for MV-modulated immune response.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 5 time sets
Platform:
GPL8300
Series:
GSE980
14 Samples
Download data: CEL
11.

Gene expression profiling of BM-derived dendritic cells reveals important mechanisms associated with predisposition to Staphylococcus infections

(Submitter supplied) Background: Staphylococcus aureus is a major pathogen of humans and animals and rapidly emerging antibiotic-resistant strains have further increased the severity of this health issue. Host genetics influence susceptibility to S. aureus infections, and genes determining infection outcome should be identified to analyze immune-based therapies as an alternative to antibiotics. Here, we used outbred animals from a divergent selection on susceptibility towards Staphylococcus infection to explore host immunogenetics. more...
Organism:
Ovis aries
Type:
Expression profiling by array
Platform:
GPL10427
44 Samples
Download data
Series
Accession:
GSE24448
ID:
200024448
12.

Functional phenotypes alteration on dendritic cells between tolerance and immnunity

(Submitter supplied) Dendritic cells (DC) are key regulators of immunological responses, immunity and tolerance. Due to their differentiation capacities, they have emerged as a promising tool for therapeutic applications. However, there are poorly understood functional DC-specific markers and cellular mechanisms for in-vitro research and clinical usage. This study’s aim is to evaluate the gene expression profiling of up-regulated or down-regulated by DC maturation and explore their function. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
3 Samples
Download data: TXT
Series
Accession:
GSE59754
ID:
200059754
13.

Murine Flt3L-derived dendritic cell-mediated early immune responses are critical to controlling cell-free HTLV-1 infection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platforms:
GPL11121 GPL11122
4 Samples
Download data
Series
Accession:
GSE24962
ID:
200024962
14.

Mouse Dendritic and Antigen Presenting Cell RT² Profiler PCR

(Submitter supplied) Infection of mouse bone marrow Flts3L-derived dendritic cells (FL-DCs) with chimeric human T cell leukemia virus type 1 (HTLV-1) results in the upregulation as well as selective downregulation of various DC-specific genes.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL11122
2 Samples
Download data: TXT
Series
Accession:
GSE24959
ID:
200024959
15.

Mouse Interferon α, β RT² Profiler PCR

(Submitter supplied) Infection of mouse bone marrow Flts3L-derived dendritic cells (FL-DCs) with chimeric human T cell leukemia virus type 1 (HTLV-1) results in the upregulation as well as selective downregulation of various interferon-stimulated genes.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL11121
2 Samples
Download data: TXT
Series
Accession:
GSE24957
ID:
200024957
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