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Links from GEO DataSets

Items: 10

1.
Full record GDS5294

HIV-1 Vpr effect on monocyte-derived macrophage

Analysis of monocyte-derived macrophages infected with a recombinant adenovirus expressing the HIV-1 Vpr protein. HIV-1 Vpr is a multi-functional protein involved in HIV-1 replication and pathogenesis. Results provide further insight into the role of HIV-1 Vpr in HIV-1 infected macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 individual sets
Platform:
GPL570
Series:
GSE56591
4 Samples
Download data: CEL
2.

Expression data from human monocyte derived macrophages infected with adenovirus expressing HIV-1 Vpr

(Submitter supplied) HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune respone and cell signaling pathways. We used the microarray analysis to elucidate the differnetail expression pattern of differnet genes in human macrophages infected with HIV-1 Vpr. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5294
Platform:
GPL570
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE56591
ID:
200056591
3.

Expression data from human monocyte derived dendritic cells infected with adenovirus expressing HIV-1 Vpr

(Submitter supplied) HIV-1 Vpr protein is a multifunctional protein which perturbs human transcriptome and interacts with a number of cellular proteins. In this study, we have attempted to explore the efffects of Vpr on human transcriptome and have identified several genes which are involved in innate immune responses. We used the microarray analysis to elucidate the differnetail expression pattern of differnet genes in human dendritic cells infected with HIV-1 Vpr. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
4 Samples
Download data: CEL
Series
Accession:
GSE61171
ID:
200061171
4.

HIV downregulates interferon stimulated genes in primary macrophages.

(Submitter supplied) HIV is able to outpace the innate immune response, including the response mediated by interferon (IFN), to establish a productive infection. However, monocyte derived macrophages (MDMs) may be protected from HIV infection by treatment with type I IFN before virus exposure. The ability of HIV to modulate the type I IFN-mediated innate immune response when it encounters a cell that has already been exposed to IFN was investigated.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
24 Samples
Download data: IDAT, SDF, TXT
Series
Accession:
GSE41731
ID:
200041731
5.

Expression data from IFN alpha 2-treated macrophages infected with HIV

(Submitter supplied) Temporal changes of the expression levels of the complete human transcriptome during the first 24 hours following infection of IFN-pre-treated macrophages. This approach has allowed us to identify genes involved in the IFN signaling that have an impact on HIV-1 infection of macrophages KEYWORDS: time course
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4232
Platform:
GPL570
17 Samples
Download data: CEL
Series
Accession:
GSE30536
ID:
200030536
6.
Full record GDS4232

HIV infection effect on interferon alpha 2-treated monocyte-derived macrophages: time course

Temporal analysis of macrophages pretreated for 18hrs with interferon alpha 2 (IFNα2) then infected with HIV-1 (Bal strain). IFN treatment prior to in vitro HIV infection inhibits virus replication. Results provide insight into molecular mechanisms underlying this modulation of viral replication.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 infection, 2 protocol, 6 time sets
Platform:
GPL570
Series:
GSE30536
17 Samples
Download data: CEL
7.

ChIP-chip from KG-1 cells with HIV Tat

(Submitter supplied) HIV-1 Tat can modulate the expression of both HIV and cellular genes. In antigen-presenting cells Tat induces the expression of a subset of interferon-stimulated genes (ISGs) in the absence of interferons (IFNs). We investigated the genome-wide Tat association with cellular promoters in immature dendritic cells (iDC) and in monocyte derived macrophages (MDM). Chromatin immunoprecipitation (ChIP) of Tat together with chromatin profiling by ChIP-on-chip analysis demonstrated that Tat associates with the MAP2K6 and MAP2K3 promoters and mediates its increase, which also affects the induction of some ISGs.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by genome tiling array
Platforms:
GPL8170 GPL8169
6 Samples
Download data: TXT
Series
Accession:
GSE42191
ID:
200042191
8.

Induction of Pathogenic Sets of Genes in Macrophages and Neurons in NeuroAIDS

(Submitter supplied) The etiology of the central nervous system (CNS) alterations after human immunodeficiency virus (HIV) infection, such as dementia and encephalitis, remains unknown. We have used microarray analysis in a monkey model of neuroAIDS to identify 98 genes, many previously unrecognized in lentiviral CNS pathogenesis, whose expression is significantly up-regulated in the frontal lobe of simian immunodeficiency virus-infected brains. more...
Organism:
Macaca mulatta; Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8300
48 Samples
Download data: CEL, EXP
Series
Accession:
GSE2377
ID:
200002377
9.

hCAF1/CNOT7 regulates interferon signaling by targeting STAT1

(Submitter supplied) Stringent regulation of the interferon signaling pathway is essential for maintaining the immune response to pathogens and tumors. The transcription factor STAT1 is a crucial mediator of this response. Here we show that hCAF1/CNOT7 regulates class I and II interferon pathways at different crucial steps. In resting cells hCAF1 can control STAT1 trafficking by interacting with the latent form of STAT1 in the cytoplasm. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL5175 GPL5188
12 Samples
Download data: CEL
Series
Accession:
GSE43334
ID:
200043334
10.

Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.

(Submitter supplied) Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neuronal deregulation. The viral protein R (Vpr), a protein encoded by HIV-1, has been shown to alter the expression of various important cytokines and inflammatory proteins in infected and uninfected cells; however the mechanisms involved remain unclear. more...
Organism:
Murid gammaherpesvirus 4; Human polyomavirus 1; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; Rattus norvegicus; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1
Type:
Expression profiling by array; Non-coding RNA profiling by array
4 related Platforms
28 Samples
Download data: CEL, GPR, TXT
Series
Accession:
GSE44266
ID:
200044266
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