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Links from GEO DataSets

Items: 20

1.
Full record GDS5306

Human epidermal growth factor receptor 2-positive breast cancer brain metastases

Analysis of HER2+ breast cancer brain metastasis specimens and HER2+ nonmetastatic primary breast tumors. Samples were matched for patient age upon primary tumor detection and ER status of primary tumor. Results provide insight into the molecular basis of HER2+ breast cancer outgrowth in the brain.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 disease state, 38 other, 38 specimen, 2 tissue sets
Platform:
GPL1352
Series:
GSE43837
38 Samples
Download data: CEL
2.

A BRCA1 Deficient-Like Signature is Enriched in Breast Cancer Brain Metastases

(Submitter supplied) Purpose: There is an unmet clinical need for biomarkers to identify breast cancer patients who are at increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways associated with HER2+ brain metastasis. Experimental Design: Gene expression of 19 HER2+ breast cancer brain metastases was compared with HER2+ nonmetastatic primary tumors. Gene Set Enrichment Analysis was used to identify a signature, which was evaluated for correlation with BRCA1 mutation status and clinical outcome using published microarray datasets and for correlation with pharmacological inhibition by a PARP inhibitor and temozolomide using published microarray datasets of breast cancer cell lines. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5306
Platform:
GPL1352
38 Samples
Download data: CEL
Series
Accession:
GSE43837
ID:
200043837
3.

A 13-gene signature predicting rapid development of brain metastases in breast cancer

(Submitter supplied) Brain metastases from breast and other cancers constitute an important part of therapeutic failures and are associated with severe morbidity and mortality. Here, we have examined histopathological data and generated gene expression data in two independent cohorts of primary tumors from HER2-positive advanced breast cancer patients. We report that the combination of estrogen receptor (ER) negativity and expression of a novel 13-gene signature identify a subset of patients with rapid (median, 31 and 41 months in discovery and validation cohorts, respectively) versus slower (median, 66 months and 77 months in discovery and validation cohorts, respectively) development of brain metastases (P<0.0001). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5826
87 Samples
Download data: TXT
Series
Accession:
GSE38057
ID:
200038057
4.

aCGH data from age-dichotomized ER+ breast tumors

(Submitter supplied) To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, DNA samples from matched ER+ invasive breast cancers diagnosed in either young (<45) or old (>70) women were analyzed with aCGH Keywords: biomarker identification
Organism:
Homo sapiens
Type:
Genome variation profiling by genome tiling array
Platform:
GPL4999
71 Samples
Download data: XLS
Series
Accession:
GSE8801
ID:
200008801
5.

Expression data from age-dichotomized ER+ breast tumors

(Submitter supplied) To investigate the biological basis between aging and sporadic breast cancer incidence and prognosis, RNA samples from matched ER+ invasive breast cancers diagnosed in either young (≤45) or old (≥70) women were analyzed by expression microarrays Keywords: biomarker identification
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL4685
47 Samples
Download data: CEL
Series
Accession:
GSE8193
ID:
200008193
6.

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion Positive Prostate Cancer

(Submitter supplied) To identify commonly altered genes between ERG, PARP1, and DNA-PKcs.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
6 Samples
Download data: TXT
Series
Accession:
GSE27723
ID:
200027723
7.

AR and c-Myb depletion effects in prostate cancer cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
60 Samples
Download data
Series
Accession:
GSE49287
ID:
200049287
8.

Genome-wide analysis of c-Myb-responsive gene expression in prostate cancer cells

(Submitter supplied) Analysis of c-Myb-regulation of gene expression. The hypothesis tested in the present study was that c-Myb influences the expression of specific sets of genes that are involved in cell cycle, DNA replication, recombination and repair. Results provide important information on c-Myb-responsive genes that may be crucial to the cell survival and the progression of prostate cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
24 Samples
Download data: TXT
Series
Accession:
GSE49286
ID:
200049286
9.

Genome-wide analysis of AR-responsive gene expression in prostate cancer cells

(Submitter supplied) Analysis of AR-regulation of gene expression. The hypothesis tested in the present study was that AR influences the expression of genes that participate in important bioprocesses in prostate cancer cells, including cell cycle, DNA replication, recombination and repair. Results provide important information on AR-responsive genes that may be crucial to the cell survival and the progression of prostate cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
36 Samples
Download data: TXT
Series
Accession:
GSE49285
ID:
200049285
10.

Identification of subtypes in HER2-positive breast cancer reveals a gene signature prognostic of outcome

(Submitter supplied) Purpose HER2 gene amplification or protein overexpression (HER2+) defines a clinically challenging subgroup of breast cancer with variable prognosis and response to therapy. We aimed to investigate the heterogeneous biological appearance and clinical behavior of HER2+ tumors using molecular profiling. Materials and Methods Hierarchical clustering of gene expression data from 58 HER2-amplified tumors of various stage, histological grade and estrogen receptor (ER) status was used to construct a HER2-derived prognostic predictor that was further evaluated in several large independent breast cancer data sets. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5345
58 Samples
Download data: GPR, TXT
Series
Accession:
GSE18328
ID:
200018328
11.

Metastatic breast cancer to the brain: implications of the local microenvironment for colonization and treatment

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8128
101 Samples
Download data
Series
Accession:
GSE14690
ID:
200014690
12.

Metastatic breast cancer to the brain: set 2

(Submitter supplied) Background: Metastases to the brain from breast cancer have a high mortality. Basal-like and HER2 positive breast cancers appear to have a high propensity to spread to the brain. The mechanisms that allow cells to colonise the brain are unclear. Methods: We have analysed matched and unpaired samples of breast cancer and brain metastases using morphology, immunophenotype and expression profiling and validated the data using in vitro cell culturing models and in vivo mice model. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8128
41 Samples
Download data
Series
Accession:
GSE14683
ID:
200014683
13.

Metastatic breast cancer to the brain: set 1

(Submitter supplied) Background: Metastases to the brain from breast cancer have a high mortality. Basal-like and HER2 positive breast cancers appear to have a high propensity to spread to the brain. The mechanisms that allow cells to colonise the brain are unclear. Methods: We have analysed matched and unpaired samples of breast cancer and brain metastases using morphology, immunophenotype and expression profiling and validated the data using in vitro cell culturing models and in vivo mice model. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL8128
60 Samples
Download data
Series
Accession:
GSE14682
ID:
200014682
14.

Intrinsic subtype and gene expression changes between matched primary and metastatic samples of breast cancer patients

(Submitter supplied) We compared expression of 105 breast cancer-related genes between matched primary and metastatic breast cancer
Organism:
Homo sapiens
Type:
Other
Platform:
GPL17071
246 Samples
Download data: TXT
Series
Accession:
GSE92977
ID:
200092977
15.

Co-targeting of the PI3K pathway improves the response of BRCA1 deficient breast cancer cells to PARP1 inhibition

(Submitter supplied) Although pre-clinical and clinical studies on PARP1 inhibitors, alone and in combination with DNA-damaging agents, show promising results, further ways to improve and broaden the scope of application of this therapeutic approach are warranted. To this end, we have investigated the possibility of improving the response of BRCA1 mutant breast cancer cells to PARP1 inhibition by co-targeting the PI3K pathway. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
15 Samples
Download data: TXT
Series
Accession:
GSE34817
ID:
200034817
16.

Gene expression of breast cancer cell lines treated with conditioned medium derived from NAF and CAF

(Submitter supplied) We treated nine lines of breast cancer cells with conditioned medium derived from NAF and CAF to study the paracrine interaction beetween stroma and tumor. Gene expression profiles for breast cancer cell lines are reported after 72h of treatment with conditioned medium derived from NAF and CAF or with control media.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
87 Samples
Download data: TXT
Series
Accession:
GSE70884
ID:
200070884
17.

Molecular profiling of breast cancer cell lines defines relevant tumor models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by array
8 related Platforms
105 Samples
Download data
Series
Accession:
GSE15376
ID:
200015376
18.

Molecular profiling of breast cancer cell lines defines relevant tumor models (gene expression)

(Submitter supplied) Summary: Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity. In particular, microarray studies have identified molecular subtypes (luminal A, luminal B, ERBB2-associated, basal-like and normal-like) with characteristic gene-expression patterns and underlying DNA copy number alterations (CNAs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7785
50 Samples
Download data
Series
Accession:
GSE15361
ID:
200015361
19.

Molecular profiling of breast cancer cell lines defines relevant tumor models (aCGH)

(Submitter supplied) Breast cancer cell lines have been used widely to investigate breast cancer pathobiology and new therapies. Breast cancer is a molecularly heterogeneous disease, and it is important to understand how well and which cell lines best model that diversity. In particular, microarray studies have identified molecular subtypes - luminal A, luminal B, ERBB2-associated, basal-like and normal-like - with characteristic gene-expression patterns and underlying DNA copy number alterations (CNAs). more...
Organism:
Homo sapiens
Type:
Genome variation profiling by array
7 related Platforms
55 Samples
Download data
Series
Accession:
GSE13914
ID:
200013914
20.

Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles

(Submitter supplied) Breast cancer is a heterogeneous disease for which prognosis and treatment strategies are largely governed by the receptor status (estrogen, progesterone and Her2-neu) of the tumor cells. Gene expression profiling of whole breast tumors further stratifies breast cancer into several molecular subtypes which also co-segregate with the receptor status of the tumor cells. We postulated that cancer associated fibroblasts (CAFs) within the tumor stroma may exhibit subtype specific gene expression profiles and thus contribute to the biology of the disease in a subtype specific manner. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
19 Samples
Download data: TXT
Series
Accession:
GSE37614
ID:
200037614
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