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Links from GEO DataSets

Items: 5

1.
Full record GDS5308

Antidepressant fluoxetine effect on depression model: ventral dentate gyrus

Analysis of ventral dentate gyrus from adults subjected to chronic corticosterone (CORT) to induce depression-like behaviors, followed by combined treatment of CORT and selective serotonin reuptake inhibitor fluoxetine. Results provide insight into the molecular basis of antidepressant resistance.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 individual sets
Platform:
GPL1261
Series:
GSE43261
19 Samples
Download data: CEL
2.

Fluoxetine resistance in mice is associated with attenuated progression of a stereotyped dentate gyrus gene expression program

(Submitter supplied) Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine are the most common treatment for major depression. However, approximately 50% of depressed patients fail to achieve an effective treatment response. Understanding how gene expression systems relate to treatment responses may be critical for understanding antidepressant resistance. Transcriptome profiling allows for the simultaneous measurement of expression levels for thousands of genes and the opportunity to utilize this information to determine mechanisms underlying antidepressant treatment responses. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS5307 GDS5308
Platform:
GPL1261
38 Samples
Download data: CEL
Series
Accession:
GSE43261
ID:
200043261
3.
Full record GDS5307

Antidepressant fluoxetine effect on depression model: dorsal dentate gyrus

Analysis of dorsal dentate gyrus from adults subjected to chronic corticosterone (CORT) to induce depression-like behaviors, followed by combined treatment of CORT and selective serotonin reuptake inhibitor fluoxetine. Results provide insight into the molecular basis of antidepressant resistance.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 individual sets
Platform:
GPL1261
Series:
GSE43261
19 Samples
Download data: CEL
4.

Epigenetics and energetics in ventral hippocampus mediate rapid antidepressant action: implications for treatment-resistance

(Submitter supplied) Although regulation of energy metabolism has been linked with multiple disorders, its role in depression and responsiveness to antidepressants is less-known. We found that an epigenetic and energetic agent, acetyl-L-carnitine (LAC, oral administration), rapidly rescued the depressive- and central and systemic metabolic-like phenotype of LAC-deficient Flinders Sensitive Line (FSL) rats. After acute stress during LAC treatment, a subset of FSL continued to respond to LAC (rFSL), whereas the other subset did not respond (nrFSL). more...
Organism:
Rattus norvegicus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18694
12 Samples
Download data: TXT
Series
Accession:
GSE83336
ID:
200083336
5.

Molecular regulation in the hippocampal dentate gyrus in the onset and treatment of depression

(Submitter supplied) Major depression is a multidimensional disorder highly prevalent in modern society. Although several classes of antidepressants (ADs) are currently available to treat depression, the effectiveness of treatment is still limited, as many patients do not show full remission; thus, there is a need to find better patients’ directed therapeutic strategies. Neuroplastic changes in several brain regions, namely in the hippocampal dentate gyrus (DG), are amongst the best correlates of depression and of ADs actions. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
21 Samples
Download data: CEL
Series
Accession:
GSE56028
ID:
200056028
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