Format
Items per page
Sort by

Send to:

Choose Destination

Links from GEO DataSets

Items: 20

1.
Full record GDS5349

Dendritic cell subsets

Analysis of FACS-sorted dermal macrophage, epidermal Langerhans and CD14+ dendritic cell (DC) subsets. DCs, monocytes and macrophages are leukocytes with critical roles in immunity. Result provide insight into molecular profiles distinguishing dermal DCs from monocyte-derived cells and macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 cell type, 6 individual sets
Platform:
GPL6884
Series:
GSE60317
11 Samples
Download data
2.

Transcriptome profile of human dermal macrophages and monocyte-derived macrophages

(Submitter supplied) DC, monocyte and macrophage networks are evolutionarily conserved but the distinct subsets have been difficult to distinguish due to shared overlapping phenotypic markers between the cells. Using transcriptome microarray profiling of human and mouse mononuclear phagocyte subsets, we have distinguished human dermal DCs from monocyte-derived cells and macrophages.
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5349
Platform:
GPL6884
11 Samples
Download data: TXT
Series
Accession:
GSE60317
ID:
200060317
3.

Transcriptional and functional profiling of human intestinal dendritic cells

(Submitter supplied) This file contains gene microarray data from subsets of human intestinal dendritic cells, as defined by their expression of CD103 and Sirpa. This will allow for better understanding of human intestinal DC subsets in general and will facilitate translation from findings in the mouse.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
11 Samples
Download data: CEL, CHP
Series
Accession:
GSE50380
ID:
200050380
4.

Genome-wide expression study of the CD11b+ subsets of dermal myeloid cells and their migratory counterparts in the draining lymph node

(Submitter supplied) Numerous CD11b+ myeloid cells are present within the dermis. They are very heterogeneous and can be divided in dermal DCs, tissue monocytes and tissue macrophages. At steady state, only CD11b+ DC migrate from the dermis to the skin draining lymph nodes whereas upon DNFB-induced inflammation, CD11b+ DC as well as dermal monocytes migrated to the lymph nodes. The objective of this study was to use gene expression profiling to rigorously identify the different subsets of dermal CD11b+ myeloid cells at steady state and upon inflammation and to characterize their functional potential.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
38 Samples
Download data: CEL
Series
Accession:
GSE49358
ID:
200049358
5.

Inflammation switches the differentiation program of Ly6Chi monocytes from anti-inflammatory macrophages to inflammatory dendritic cells in the colon

(Submitter supplied) Dendritic cells (DCs) and macrophages (MPs) are important for immunological homeostasis in the colon. We found that F4/80hi CX3CR1hi (CD11b+CD103-) cells account for 80% of mouse colonic lamina propria (cLP) MHC-IIhi cells. Both CD11c+ and CD11c- cells within this population were identified as MPs based on multiple criteria, including a MP transcriptome revealed by microarray analysis. These MPs constitutively released high levels of IL-10 at least partially in response to the microbiota via an MyD88-independent mechanism. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4369
Platform:
GPL6246
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE27859
ID:
200027859
6.
Full record GDS4369

Normal colonic lamina propria macrophage and dendritic cell populations

Analysis of sorted, steady-state colonic cells subdivided into 4 populations: 2 DC subsets and 2 MP subsets based on CD11c and F4/80 expression. DCs and MPs are important for immunological homeostasis in colon. Results provide insight into molecular characterization of colonic MP and DC populations.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 cell type sets
Platform:
GPL6246
Series:
GSE27859
10 Samples
Download data: CEL, CHP
7.

Transcriptome profile of mouse lung dendritic cell subsets and macrophages.

(Submitter supplied) Dendritic cell (DC) are critical initiators and regulators of immunity to pathogens, vaccines, tumors and tolerance to self. Mouse and human dendritic cells (DCs) are comprised of functionally specialized subsets, but precise interspecies correlation is currently incomplete and hampers the full translation of murine findings to human DC-based clinical therapies. In this study, we show that murine lung and gut lamina propria CD11b+ DC populations are comprised of two subsets: FLT3- and IRF4-dependent CD24+CD64- DCs and contaminating CSF-1R-dependent CD24-CD64+ macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
6 Samples
Download data: TXT
Series
Accession:
GSE46680
ID:
200046680
8.

Lineage relationship in human dendritic cells - cDNA arrays

(Submitter supplied) The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compared this to monocyte derived DC (MDDC) and MUTZ3 Langerhans cells (LCs) to define the lineage relationships. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL14674
62 Samples
Download data: GPR
Series
Accession:
GSE32648
ID:
200032648
9.

Lineage relationship in human dendritic cells

(Submitter supplied) The lineage relationships and fate of human blood and tissue dendritic cells (DC) has significance for a number of diseases including HIV where both blood and tissue DC may be infected. We used gene expression profiling of monocyte and DC sub-populations sorted directly from blood and skin and compared this to monocyte derived DC (MDDC) and MUTZ3 Langerhans cells (LCs) to define the lineage relationships. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6884
24 Samples
Download data: TXT
Series
Accession:
GSE32400
ID:
200032400
10.

Transcriptome profiles of mouse and human monocyte and dendritic cell subsets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL6887 GPL10558
64 Samples
Download data
Series
Accession:
GSE35459
ID:
200035459
11.

Transcriptome profiles of mouse and human monocyte and dendritic cell subsets (mouse data)

(Submitter supplied) Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic CD8+ DC and CD103+ DC possess potent antigen cross-presenting capacity. Although recent evidence points to human blood CD141+ DCs as the functional equivalent of CD8+ DC, the precise identity of the human migratory cross-presenting DC has remained elusive. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
15 Samples
Download data: TXT
Series
Accession:
GSE35458
ID:
200035458
12.

Transcriptome profiles of mouse and human monocyte and dendritic cell subsets (human data)

(Submitter supplied) Dendritic cells (DCs) are critical in mediating immunity to pathogens, vaccines, tumors and tolerance to self. Significant progress has been made in the study of DC subsets in murine models but the translation of these findings to human DC immunobiology has not been fully realized. Murine splenic CD8+ DC and CD103+ DC possess potent antigen cross-presenting capacity. Although recent evidence points to human blood CD141+ DCs as the functional equivalent of CD8+ DC, the precise identity of the human migratory cross-presenting DC has remained elusive. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
49 Samples
Download data: TXT
Series
Accession:
GSE35457
ID:
200035457
13.

RNAseq of renal CD64+CD11b+F4/80hi from adult mice after cisplatin-induced acute kidney injury

(Submitter supplied) We use bulk RNA sequencing of sorted cells to characterize the gene expression profiles of renal MHCII+/-D11b+F4/80hi cells 72 hours after cisplatin-induced acute kidney injury (AKI). F4/80hi cells are activated after cisplatin induced AKI and start to downregulate MHCII on transcriptional level. Downregulation of MHCII is probably caused by a downregulation/inhibition of its most important transcriptional activator Ciita
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
8 Samples
Download data: CSV, TAB, TXT
Series
Accession:
GSE135921
ID:
200135921
14.

RNAseq of renal dendritic cells from adult Clec9a-Cre Rosa-YFP mice

(Submitter supplied) We use bulk RNA sequencing of sorted cells to characterize the gene expression profiles of renal dendritic cell (DC) subsets, cDC1 and cDC2, as well as MHCII+CD64+ F4/80hi and MHCII+CD64+ CD11bhi cells. Splenic DCs and red pulp macrophages serve as reference populations for a macrophage-like or DC-like phenotype. By sorting YFP+/YFP- F4/80hi or YFP+/YFP- CD11bhi cells from Clec9a-Cre Rosa-YFP mice we aim to reveal transcriptional differences between YFP-labelled and unlabelled cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18480
33 Samples
Download data: CSV, TAB, TXT
Series
Accession:
GSE131751
ID:
200131751
15.

Human CD1c+ dendritic cells drive the differentiation of CD103+ CD8+ mucosal T cells via TGF-β

(Submitter supplied) In comparison to murine dendritic cells (DCs), less is known about the function of human DCs in tissues. Here, we analyzed, using lung tissues from humans and humanized mice, the role of human CD1c+ and CD141+ DCs in determining the type of CD8+ T cell immunity to live-attenuated influenza virus (LAIV) vaccine. We found that both lung DC subsets acquired influenza antigens in vivo and expanded specific cytotoxic CD8+ T cells in vitro. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL10558
18 Samples
Download data: TXT
Series
Accession:
GSE43184
ID:
200043184
16.

Sheep dendritic cells CD26+ and CD26- versus total dendritic cells

(Submitter supplied) Transcriptomic profiling of ovine skin lymph dendritic cell subsets CD26+ and CD26- compared to total enriched lymph dendritic cells. CD26+ and CD26- dendritic cells (DC) from sheep skin lymph were sorted by flow cytometry and were analysed for their transcriptomic profile. We demonstrate that the minor sheep CD26+ skin lymph DC subset shares significant transcriptomic similarities with mouse CD8a+ and human BDCA3+ DC. more...
Organism:
Ovis aries
Type:
Expression profiling by array
Platform:
GPL10427
5 Samples
Download data: TXT
Series
Accession:
GSE21889
ID:
200021889
17.

Comparative genomics analysis of mononuclear phagocyte subsets confirms similarity between lymphoid tissue-resident and dermal XCR1+ DCs in mouse and human and distinguishes them from Langerhans cells.

(Submitter supplied) Dendritic cells (DC) are mononuclear phagocytes which exhibit a dendritic morphology and excel at naïve T cell activation. DC encompass several subsets initially identified by their expression of specific cell surface molecules and later shown to possess distinct functions. DC subset differentiation is guided by different transcription factors and cytokines. Identifying DC subsets is challenging as very few cell surface molecules are uniquely expressed on any one of these cell populations and conventional flow cytometry analysis using limited antigens is biased and potentially misleading. more...
Organism:
Mus musculus; Homo sapiens
Type:
Third-party reanalysis; Expression profiling by array
Download data: TXT
Series
Accession:
GSE74316
ID:
200074316
18.

Gene expression profiling of plasmacytoid dendritic cells from cutaneous lymph nodes

(Submitter supplied) Plasmacytoid dendritic cells wre isolated from cutaneous lymph nodes of control C57BL/6 mice and used for microarray analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
3 Samples
Download data: CEL
Series
Accession:
GSE74276
ID:
200074276
19.

ImmGen Microarray Phase 1

(Submitter supplied) Gene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
653 Samples
Download data: CEL
Series
Accession:
GSE15907
ID:
200015907
20.

Transcriptional profiling of small intestinal lamina propria Dendritic cells by microarray

(Submitter supplied) CD103+CD11b+ dendritic cells (DC) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGF beta 1) has an indispensable, cell intrinsic role in the development of these cells. Deletion of Tgfbr1 results in markedly fewer intestinal CD103+CD11b+ DCs and a reciprocal increase in the CD103–CD11b+ DC subset. Transcriptional profiling identifies markers that define the CD103+CD11b+ DC lineage, including CD101, TREM1 and Siglec-F, and shows that the absence of CD103+CD11b+ DCs in CD11c-Cre.Tgfbr1fl/fl mice reflects defective differentiation from CD103–CD11b+ intermediaries, rather than an isolated loss of CD103 expression. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
15 Samples
Download data: CEL
Series
Accession:
GSE100393
ID:
200100393
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=|query=1|qty=4|blobid=MCID_617af3bcdfb3cd6c657a48b5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center