GEO DataSets

Analysis of patient PTCL/NOS cells treated with imatinib mesylate (1uM, 6h). PTCL/NOS tumors are characterized by aberrant expression of platelet-derived growth factor receptor α (PDGFRA). Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL570

Series:

GSE53633

4 Samples

Download data: CEL

(Submitter supplied) Identification of the determinants of PDGFRA activity in PTCL/NOS (Peripheral T-cell lymphoma/not otherwise specified) and to elucidate the biological consequences of its activation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5405 GDS5406

Platform:

GPL570

8 Samples

Download data: CEL

Analysis of EOL-1 cells treated with imatinib mesylate (1uM, 6h). EOL-1 cells carry the platelet derived growth factor receptor α (PDGFRA)/FIP1L1 fusion and exhibit constitutive PDGFRA activation. Results provide insight into the molecular effects of inhibiting PDGFRA signaling by imatinib.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL570

Series:

GSE53633

4 Samples

Download data: CEL

(Submitter supplied) Intimal sarcoma (IS) is a rare, malignant and aggressive tumor that shows a relentless course with a concomitant low survival rate, for which no effective treatment is available. In this study, 21 cases of large arterial blood vessel IS were analyzed by immunohistochemistry and fluorescent in situ hydridisation (FISH), and selectively by karyotyping, array-CGH, sequencing, phospho-kinase antibody arrays and Western immunoblotting, in search for the novel diagnostic markers and potential molecular targets. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL4091

8 Samples

Download data: PDF, TXT

(Submitter supplied) To identify potential targets of miR-34a, we performed transcriptional profiling on proneural TS543 GBM cells, focusing on mRNAs whose levels decreased in response to miR-34a transfection as compared to control oligonucleotide.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

6 Samples

Download data

(Submitter supplied) Overall study: Identification of PDGF-dependent patterns of gene expression in U87 glioblastoma cells. RNA was obtained from triplicate dishes of 5 different groups of U87 cells, each (total 15) analyzed with one U95 microarray chip. Three different comparisons were made: 1) Clone 3.1 (34580-34582) vs. clone 3.3 (34583-34585) vs. parent U87 (34592-34594). Purpose: demonstrate that the gene expression profiles between these 3 cell lines are not different, so they could be pooled as a single untreated group. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1730

Platform:

GPL8300

15 Samples

Download data: CEL, EXP

Analysis of U87 glioblastoma (GBM) cell clones overexpressing a dominant-negative form of platelet-derived growth factor (PDGF) A subunit to inactive the PDGF autocrine signaling loop. The autocrine PDGF loop is a hallmark of GBM. Results identify genes regulated by oncogenic PDGF signaling.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 3 genotype/variation sets

Platform:

GPL8300

Series:

GSE1923

15 Samples

Download data: CEL, EXP

(Submitter supplied) Little is known about the genetic regulation of medulloblastoma dissemination, but metastatic medulloblastoma is highly associated with poor outcome. We obtained expression profiles of 23 primary medulloblastomas clinically designated as either metastatic (M+) or non-metastatic (M0) and identified 85 genes whose expression differed significantly between classes. Using a class prediction algorithm based on these genes and a leave-one-out approach, we assigned sample class to these tumors (M+ or M0) with 72% accuracy and to four additional independent tumors with 100% accuracy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS232

Platform:

GPL74

23 Samples

Download data: CEL

Identification of genes causing medulloblastoma tumors to metastasize. Analyzed 23 primary medulloblastomas clinically designated as either metastatic or non-metastatic.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state sets

Platform:

GPL74

Series:

GSE468

23 Samples

Download data: CEL