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Links from GEO DataSets

Items: 13

1.
Full record GDS5412

Age effect on respiratory epithelium: distal trachea and carina region

Analysis of distal trachea and carina region of young (2 month) and old (14 month) C57Bl/6 females. Aging lungs are associated with a variety of structural and pathologic changes. Results provide insight into molecular mechanisms underlying age-related changes in respiratory epithelium.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL1261
Series:
GSE55162
8 Samples
Download data: CEL
2.

Age-related changes in the cellular composition and epithelial organization of the mouse trachea

(Submitter supplied) We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and the main stem bronchi. We confirm previous reports of the graduate appearance of age-related, gland-like structures (ARGLS) in the submucosa, espeically in the intercartilage regions and carina. Immunohistochemistry shows these structures contain ciliated and secretory cells and Krt5+ basal cells, but not the myoepithelial cells or ciliated ducts typical of normal submucosal glands. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5412
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE55162
ID:
200055162
3.

Gene expression data from mouse tracheal cells before and 48hrs after SO2 injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE69058
ID:
200069058
4.

Gene expression data from mouse tracheal mesenchymal cells before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is underlaid by mesenchymal cells that include vasculature, smooth muscle, fibroblasts and cartilage. The goal of this project is to identify cellular and molecular changes in the mesenchyme after injury to the epithelium by exposure to SO2 and which may participate in repair of the epithelium We used Affymetrix microarray analysis to compare transcripts in tracheal mesenchyme before and after SO2 injury.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE69057
ID:
200069057
5.

Gene expression data from mouse tracheal epithelial cells isolated before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is made up of about equal proportions of ciliated and secretory cells. In addition, in regions where the epithelium is pseudostratfied, ~30% of the epithelium consists of undifferentiated basal cells (BCs). Evidence suggests that these BCs are multipotent stem cells that can self renew over the long term and give rise to both ciliated and secretory lineages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE69056
ID:
200069056
6.

Gene expression in mouse tracheal basal cells

(Submitter supplied) Epithelial basal cells (BCs) are an important stem cell population of the airways. We purified BCs from a KRT5-GFP transgenic mouse line and used Affymetrix arrays to compare there gene expression to that of non-BC epithelium.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE15724
ID:
200015724
7.

Polidocanol injury wildtype versus Myd88 KO trachea

(Submitter supplied) Nf-kB activity is associated with the key pathological features of chronic respiratory diseases including epithelial remodelling, excess mucous production, and submucosal gland hyperplasia. However, the role of Nf-kB activity in airway epithelial differentiation remains controversial. In the present study we demonstrate that Nf-kB adaptor protein Myd88 deficiency promotes increased airway submucosal gland abundance and abnormal epithelial differentiation in proximal adult airways. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
20 Samples
Download data: TXT
Series
Accession:
GSE17268
ID:
200017268
8.

Myb permits multilineage airway epithelial cell differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL17543 GPL19077
21 Samples
Download data: CSV, GPR
Series
Accession:
GSE60369
ID:
200060369
9.

Effects of Myb shRNA on Airway Epithelial Cells

(Submitter supplied) The epithelium of the pulmonary airway is specially differentiated to provide defense against environmental insults, but also subject to dysregulated differentiation that results in lung disease. The current paradigm for airway epithelial differentiation is a one-step program whereby a p63+ basal epithelial progenitor cell generates a ciliated or secretory cell lineage, but the cue for this transition and whether there are intermediate steps is poorly defined. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17543
12 Samples
Download data: TXT
Series
Accession:
GSE60365
ID:
200060365
10.

Mouse Tracheal Epithelial Cell Air-Liquid Interface Primary Culture Time Course (ALI d0, d2, d7)

(Submitter supplied) Mouse tracheal epithelial cells were cultured at air-liquid interface (ALI), RNA was harvested at days 0, 2, and 7 post-ALI, and hybridized to two-channel MEEBO arrays. The experiment was designed to allow investigators to identify genes differentially expressed during airway epithelial cell differentiation and development, including ciliogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL19077
9 Samples
Download data: CSV, GPR
Series
Accession:
GSE60364
ID:
200060364
11.

The effects of Lef-1 overexpression on culture-expanded MECs

(Submitter supplied) The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airway repair—basal cells in the surface airway epithelium (SAE) and an unknown submucosal gland (SMG) cell type. Whether a lineage relationship exists between these two stem cell compartments remains unclear. Using lineage tracing of glandular myoepithelial cells (MECs), we demonstrate that MECs can give rise to seven cell types of the SAE and SMGs following severe airway injury. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
9 Samples
Download data: TXT, XLSX
Series
Accession:
GSE111650
ID:
200111650
12.

Expression data from surface airway epithelial basal cells, ciliated cells, and club cells.

(Submitter supplied) To identify key genes that define surface airway epithelial (SAE) basal cells, we FACS isolated basal, ciliated, and club cell populations as previously reported (Zhao et al., 2014; PMID: 25043474) and performed microarray analysis on isolated mRNA. For fractionating SAE into basal, club, and ciliated populations, cells were stained with EpCAM-PECy7 (eBiosciences), GSIβ4-FITC (Sigma), SSEA1-Alexa Fluor® 647 (BioLegend), and CD24-PE (BD Pharmingen) for 30 minutes on ice as previously described (Zhao et al., 2014), prior to FACS. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, XLSX
Series
Accession:
GSE111557
ID:
200111557
13.

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

(Submitter supplied) Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium and goes on to drive development of most chronic lung diseases. Here, through single cell RNA-sequencing analysis of the tracheal epithelium from smokers and nonsmokers, we generate a comprehensive atlas of epithelial cell types and states, connect these into lineages, and define cell-specific responses to smoking. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
28 Samples
Download data: RDATA, TXT
Series
Accession:
GSE134174
ID:
200134174
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