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Links from GEO DataSets

Items: 20

1.
Full record GDS5412

Age effect on respiratory epithelium: distal trachea and carina region

Analysis of distal trachea and carina region of young (2 month) and old (14 month) C57Bl/6 females. Aging lungs are associated with a variety of structural and pathologic changes. Results provide insight into molecular mechanisms underlying age-related changes in respiratory epithelium.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age sets
Platform:
GPL1261
Series:
GSE55162
8 Samples
Download data: CEL
2.

Age-related changes in the cellular composition and epithelial organization of the mouse trachea

(Submitter supplied) We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and the main stem bronchi. We confirm previous reports of the graduate appearance of age-related, gland-like structures (ARGLS) in the submucosa, espeically in the intercartilage regions and carina. Immunohistochemistry shows these structures contain ciliated and secretory cells and Krt5+ basal cells, but not the myoepithelial cells or ciliated ducts typical of normal submucosal glands. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5412
Platform:
GPL1261
8 Samples
Download data: CEL
Series
Accession:
GSE55162
ID:
200055162
3.

Gene expression data from mouse tracheal cells before and 48hrs after SO2 injury

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
12 Samples
Download data: CEL
Series
Accession:
GSE69058
ID:
200069058
4.

Gene expression data from mouse tracheal mesenchymal cells before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is underlaid by mesenchymal cells that include vasculature, smooth muscle, fibroblasts and cartilage. The goal of this project is to identify cellular and molecular changes in the mesenchyme after injury to the epithelium by exposure to SO2 and which may participate in repair of the epithelium We used Affymetrix microarray analysis to compare transcripts in tracheal mesenchyme before and after SO2 injury.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE69057
ID:
200069057
5.

Gene expression data from mouse tracheal epithelial cells isolated before and 48hrs after SO2 injury

(Submitter supplied) The conducting airway epithelium of the rodent and human lung is made up of about equal proportions of ciliated and secretory cells. In addition, in regions where the epithelium is pseudostratfied, ~30% of the epithelium consists of undifferentiated basal cells (BCs). Evidence suggests that these BCs are multipotent stem cells that can self renew over the long term and give rise to both ciliated and secretory lineages. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE69056
ID:
200069056
6.

Beta-catenin dependent gene expression

(Submitter supplied) Gene experssion was evaluated in the lungs of mice in which beta-catenin was stabilized or knocked out in the SCGB1A1 lineage. Gene expression was assayed on post-natal day 21
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE119687
ID:
200119687
7.

Polidocanol injury wildtype versus Myd88 KO trachea

(Submitter supplied) Nf-kB activity is associated with the key pathological features of chronic respiratory diseases including epithelial remodelling, excess mucous production, and submucosal gland hyperplasia. However, the role of Nf-kB activity in airway epithelial differentiation remains controversial. In the present study we demonstrate that Nf-kB adaptor protein Myd88 deficiency promotes increased airway submucosal gland abundance and abnormal epithelial differentiation in proximal adult airways. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL4134
20 Samples
Download data: TXT
Series
Accession:
GSE17268
ID:
200017268
8.

Gene expression in mouse tracheal basal cells

(Submitter supplied) Epithelial basal cells (BCs) are an important stem cell population of the airways. We purified BCs from a KRT5-GFP transgenic mouse line and used Affymetrix arrays to compare there gene expression to that of non-BC epithelium.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE15724
ID:
200015724
9.

Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; synthetic construct
Type:
Expression profiling by array; Non-coding RNA profiling by array
Platforms:
GPL570 GPL8786
18 Samples
Download data: CEL
Series
Accession:
GSE39061
ID:
200039061
10.

Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [miRNA]

(Submitter supplied) Normal human bronchial epithelial (NHBE) cells cultured in an air-liquid interface (ALI) system form a polarized, pseudostratified epithelium composed of basal, ciliated and goblet cells that closely resemble the in vivo airway epithelium structure. ALI cultures of NHBE cells provide a unique in vitro system to investigate airway epithelial biology, including developmental, structural and physiologic aspects. more...
Organism:
synthetic construct; Homo sapiens
Type:
Non-coding RNA profiling by array
Platform:
GPL8786
9 Samples
Download data: CEL
Series
Accession:
GSE39060
ID:
200039060
11.

Changes in microRNA and mRNA expression with differentiation of human bronchial epithelial cells [mRNA]

(Submitter supplied) Normal human bronchial epithelial (NHBE) cells cultured in an air-liquid interface (ALI) system form a polarized, pseudostratified epithelium composed of basal, ciliated and goblet cells that closely resemble the in vivo airway epithelium structure. ALI cultures of NHBE cells provide a unique in vitro system to investigate airway epithelial biology, including developmental, structural and physiologic aspects. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
9 Samples
Download data: CEL
Series
Accession:
GSE39059
ID:
200039059
12.

The effects of Lef-1 overexpression on culture-expanded MECs

(Submitter supplied) The mouse trachea is thought to contain two distinct stem cell compartments that contribute to airway repair—basal cells in the surface airway epithelium (SAE) and an unknown submucosal gland (SMG) cell type. Whether a lineage relationship exists between these two stem cell compartments remains unclear. Using lineage tracing of glandular myoepithelial cells (MECs), we demonstrate that MECs can give rise to seven cell types of the SAE and SMGs following severe airway injury. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
9 Samples
Download data: TXT, XLSX
Series
Accession:
GSE111650
ID:
200111650
13.

Expression data from surface airway epithelial basal cells, ciliated cells, and club cells.

(Submitter supplied) To identify key genes that define surface airway epithelial (SAE) basal cells, we FACS isolated basal, ciliated, and club cell populations as previously reported (Zhao et al., 2014; PMID: 25043474) and performed microarray analysis on isolated mRNA. For fractionating SAE into basal, club, and ciliated populations, cells were stained with EpCAM-PECy7 (eBiosciences), GSIβ4-FITC (Sigma), SSEA1-Alexa Fluor® 647 (BioLegend), and CD24-PE (BD Pharmingen) for 30 minutes on ice as previously described (Zhao et al., 2014), prior to FACS. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, XLSX
Series
Accession:
GSE111557
ID:
200111557
14.

p63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (tracheal epithelium and alveoli)

(Submitter supplied) The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regeneration in mice following H1N1 influenza virus infection and implicated p63+Krt5+ distal airway stem cells, or DASCp63/Krt5, in this process. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE61091
ID:
200061091
15.

p63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
26 Samples
Download data: CEL, CHP
Series
Accession:
GSE60849
ID:
200060849
16.

p63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (transplanted and damaged)

(Submitter supplied) The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regeneration in mice following H1N1 influenza virus infection and implicated p63+Krt5+ distal airway stem cells, or DASCp63/Krt5, in this process. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE60830
ID:
200060830
17.

p63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (Dtox treatment)

(Submitter supplied) The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regeneration in mice following H1N1 influenza virus infection and implicated p63+Krt5+ distal airway stem cells, or DASCp63/Krt5, in this process. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE60829
ID:
200060829
18.

p63+/Krt5+ Distal Airway Stem Cells are Essential for Lung Regeneration (before and after in vitro differentiation)

(Submitter supplied) The possibility of lung regeneration has been long discounted due to the irreversible nature of chronic lung diseases. However, patients who sustain massive loss of lung tissue during acute infections often recover full pulmonary function. Correspondingly, we previously demonstrated lung regeneration in mice following H1N1 influenza virus infection and implicated p63+Krt5+ distal airway stem cells, or DASCp63/Krt5, in this process. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6193
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE60828
ID:
200060828
19.

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

(Submitter supplied) Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium and goes on to drive development of most chronic lung diseases. Here, through single cell RNA-sequencing analysis of the tracheal epithelium from smokers and nonsmokers, we generate a comprehensive atlas of epithelial cell types and states, connect these into lineages, and define cell-specific responses to smoking. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
28 Samples
Download data: RDATA, TXT
Series
Accession:
GSE134174
ID:
200134174
20.

Transcriptional profiling of ICAM-positive and -negative cells from the mouse olfactory epithelium

(Submitter supplied) We used trasncriptional profiling of fluorescent activated cell sorting (FACS) purified ICAM1-positive and negative cells from the olfactory epithelium (OE) of three-week old mice to identify genes enriched in the horizontal basal cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE31972
ID:
200031972
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