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Links from GEO DataSets

Items: 18

1.
Full record GDS5415

Model for Wilms tumor of the kidney: time course

Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 age, 2 disease state sets
Platform:
GPL6885
Series:
GSE56323
8 Samples
Download data
2.

Lin28 sustains early renal progenitors and induces Wilms tumor

(Submitter supplied) Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that over-expression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in pathology highly reminiscent of Wilms tumor.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5415
Platform:
GPL6885
8 Samples
Download data: TXT
Series
Accession:
GSE56323
ID:
200056323
3.

Chromatin Analysis of Wilms Tumor Highlights Stem Cell Properties and a Renal Developmental Network

(Submitter supplied) Wilms tumors are pediatric cancers thought to arise from kidney-specific stem cells. In order to identify transcriptional and epigenetic mechanisms that drive these malignant cells, we compared genomewide chromatin profiles of Wilms tumors to embryonic stem (ES) cells and normal kidney.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9052
12 Samples
Download data: WIG
Series
Accession:
GSE20512
ID:
200020512
4.

Lin28 expression affect embryonic lung development

(Submitter supplied) Lin28A and its paralog Lin28B are RNA binding proteins that regulate gene expression by inhibition of the maturation of the Per/Pri Let-7 miRNAs family and also via Let-7 independent mechanism. To study the effect of Lin28A ectopic-expression on mouse embryonic development we used a transgenic mice strain that combine a Cre-Lox system and a Tet-On system (herein Lox-stop-Lox-TetOn-Lin28A mice) and enable spatial and temporal control of transgenic Lin28A over-expression. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
34 Samples
Download data: XLSX
Series
Accession:
GSE122919
ID:
200122919
5.

LIN28 cooperates with Wnt signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans

(Submitter supplied) In this study, we investigated the role of LIN28 in intestinal tumor initiation and invasive progression. We generated animal models with just intestinal LIN28B overexpression, or in combination with Apcmin/+ background. The animals develop intestinal and colorectal tumors with histology ranging from adenoma to adenocarcinoma.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6885
16 Samples
Download data: IDAT, TXT
Series
Accession:
GSE68334
ID:
200068334
6.

Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation

(Submitter supplied) To characterize the in vivo role of DROSHA mutations during kidney development and their oncogenic potential, we analyzed mouse lines with either a targeted deletion of Drosha or an inducible expression of human DROSHA carrying a tumor-specific E1147K mutation that acts in a dominant negative manner.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL23479
9 Samples
Download data: TXT
Series
Accession:
GSE117665
ID:
200117665
7.

Gene expression profiling in Dis3l2-null and wild-type nephron progenitor cells

(Submitter supplied) Purpose: Loss of DIS3L2 in humans is associated with congenital overgrowth in Perlman syndrome, as well as with the development of Wilms tumors. DIS3L2 is an exoribonuclease with a demonstrated preference for 3’-uridylated RNA substrates. However, its targets relevant to human disease are poorly understood. Our goal was to address transcriptomic changes in DIS3L2 deficient mouse nephron progenitor cells, a cell type of the developing kidney with demonstrated relevance to Wilms tumorigenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
5 Samples
Download data: TXT
Series
Accession:
GSE114673
ID:
200114673
8.

Lin28/let-7 axis regulates the timig of cession of nephrogenesis

(Submitter supplied) To study role of Lin28/let-7 axis on nephrogenesis, we profiled kidney transcriptom of LIN28 OE, let-7 KO, and their wild-type littermate control mice.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: BEDGRAPH, BW, TXT
Series
Accession:
GSE117510
ID:
200117510
9.

Effect of LIN28 on miRNA profile at day 5 of neurogliogenesis in vitro

(Submitter supplied) Comparison of mouse P19 and P19+Lin28 cells at day 5 of retinoic acid-induced differentiation The cell lines differ in that one constitutively expresses Lin28 from a heterologous promoter.
Organism:
Rattus norvegicus; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Murid betaherpesvirus 1; Human gammaherpesvirus 4; Human immunodeficiency virus 1; JC polyomavirus; Human gammaherpesvirus 8; Macaca mulatta polyomavirus 1; Homo sapiens; Murid gammaherpesvirus 4; Human polyomavirus 1
Type:
Non-coding RNA profiling by array
Platform:
GPL7722
4 Samples
Download data: TXT
Series
Accession:
GSE19858
ID:
200019858
10.

P19 cells+LIN28_RA-differentiated_Day 4

(Submitter supplied) LIN28 is an RNA-binding protein expressed in many developing tissues. It can block let-7 microRNA processing and help promote pluripotency. We observe LIN28 expression in the developing neural tube, colocalizing with SOX2, suggesting a role in neural development. To better understand its normal developmental function, we investigated LIN28 activity during neurogliogenesis in vitro where the succession of neuronal to glial cell fates occurs as it does in vivo. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
4 Samples
Download data: CEL
Series
Accession:
GSE19705
ID:
200019705
11.

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis in Wilms tumors

(Submitter supplied) Through whole-exome sequencing we identified somatic missense mutations in DICER1 and DROSHA in Wilms tumor, a childhood kidney cancer. DICER1 and DROSHA are key enzymes in the microRNA biogenesis pathway. To determine the effect of these mutations on microRNA expression, we prepared small RNAs from Wilms tumors and used next-generation sequencing to determine the expression levels of microRNAs in the tumors.
Organism:
Homo sapiens
Type:
Non-coding RNA profiling by high throughput sequencing
Platform:
GPL16288
12 Samples
Download data: GFF
Series
Accession:
GSE56955
ID:
200056955
12.

LIN28B is a barrier to the maturation of human embryonic stem cell derived pancreatic β cells

(Submitter supplied) Comparative RNA and small RNA sequencing analysis of in vitro differentiated β like cells, in vivo matured β cells, adult islet cells, and Lin28 deficient in vitro differentiated β like cells
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing
Platform:
GPL11154
24 Samples
Download data: TXT
Series
Accession:
GSE108654
ID:
200108654
13.

Zebrafish embryos: Control MO vs. Lin28A MO vs. Lin28B MO injected

(Submitter supplied) miRNA profiling of zebrafish embryos comparing control MO with Lin28A MO or Lin28B MO injected embryos at 5hpf
Organism:
Danio rerio
Type:
Non-coding RNA profiling by array
Platform:
GPL17951
3 Samples
Download data: TXT
Series
Accession:
GSE52492
ID:
200052492
14.

Wilms Tumor cells with WT1 mutations have characteristic features of mesenchymal stem cells

(Submitter supplied) Wilms tumors are genetically heterogeneous kidney tumors whose cells of origin are unknown. Tumors with WT1 mutations and concomitant loss of the wild-type allele represent a distinct subgroup, frequently associated with mutations in CTNNB1. Here we describe the establishment and characterization of long-term cell cultures derived from five individual Wilms tumors with WT1 mutations. Three of these tumor cell lines also had CTNNB1 mutations and an activated canonical Wnt signaling pathway as measured by β-catenin/TCF transcriptional activity. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
29 Samples
Download data: TXT
Series
Accession:
GSE18058
ID:
200018058
15.

A transcriptome-wide divergence in protein translation scales with LIN28B expression

(Submitter supplied) We report the mapping of LIN28B binding to RNA in HEK293A at various LIN28B expression levels using enhanced CLIP. We provide small RNA sequencing data regarding miRNA expression in HEK293A and those miRNAs bound by AGO2. We also profile the effect of LIN28B expression on transcriptome-wide ribosome occupancy in HEK293A via RNA-seq. Finally, we provide orthogonal regulatory data by profiling the effect of LIN28B expression on transcriptome-wide ribosome occupancy in NIH3T3 via RNA-seq.
Organism:
Homo sapiens; Mus musculus
Type:
Other; Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL20301 GPL21103
30 Samples
Download data: CSV, TXT
16.

LIN28B and colon cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
15 Samples
Download data: CEL
Series
Accession:
GSE26336
ID:
200026336
17.

Expression data from xenograft tumors derived from LoVo colon cancer lines +/- constitutive LIN28B expression

(Submitter supplied) We sought to elucidate functions of LIN28B and potential mechanisms whereby it may promote metastasis by comparing the gene expression profile of LIN28B metastases to primary tumors. Accordingly, we performed microarray analysis on total RNA isolated from empty vector tumors, LIN28B-LoVo tumors, and LIN28B-LoVo metastases
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
9 Samples
Download data: CEL
Series
Accession:
GSE26335
ID:
200026335
18.

Expression data from LoVo colon cancer lines +/- constitutive LIN28B expression

(Submitter supplied) We sought to elucidate the molecular mechanisms whereby LIN28B functions by comparing the gene expression profile of cells constitutively expressing LIN28B to empty vector controls. Accordingly, we performed microarray analysis on total RNA isolated from empty vector LoVo and LIN28B-expressing LoVo colon cancer cell lines.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
6 Samples
Download data: CEL
Series
Accession:
GSE26334
ID:
200026334
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