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Links from GEO DataSets

Items: 8

1.
Full record GDS5418

Glucose effect on steroid receptor coactivator 1 deficient-A549 lung cancer epithelial cell line

Analysis of highly glycolytic A549 lung cancer cells depleted for steroid receptor coactivator SRC-1 and grown in the absence of glucose. SRC-1 promotes gluconeogenesis and glycemia. Results provide insight into the role of SRC-1 in glycolytic cancer cells undergoing glucose deprivation.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets
Platform:
GPL570
Series:
GSE56843
8 Samples
Download data: CEL
2.

Steroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis

(Submitter supplied) SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycolytic cancer cells abrogated their ability to grow in the absence of glucose consistent with SRC-1's role in promoting cellular adaptation to reduced glucose availability
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5418
Platform:
GPL570
8 Samples
Download data: CEL
Series
Accession:
GSE56843
ID:
200056843
3.

Transcription array by profiling in WT and SRC-2 null mouse liver

(Submitter supplied) The molecular targets of SRC-2 regulation in the murine liver stimulate fatty acid degradation and glycolytic pathway while fatty acid, cholesterol, and steroid biosynthetic pathways are down-regulated.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4785
Platform:
GPL1261
6 Samples
Download data: CEL
Series
Accession:
GSE55002
ID:
200055002
4.
Full record GDS4785

Steroid receptor coactivator-2 deficiency effect on the liver

Analysis of livers from C57 females lacking Steroid receptor coactivator-2 (SRC-2). SRC-2 is a mediator of steroid receptor action. Results provide insight into the role of steroid receptor coactivators in hepatic metabolism.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE55002
6 Samples
Download data: CEL
DataSet
Accession:
GDS4785
ID:
4785
5.

HoxC11 ChIP-seq of LY2 Breast Cancer Cell Line

(Submitter supplied) SRC-1 (NCOA1) is a steroid receptor coactivator that has been associated with various aspects of the progression of breast cancer disease such as tamoxifen resistance, metastasis, cell proliferation and invasiveness. In a tamoxifen resistant breast cancer cell line (LY2), SRC-1 has been found to interact with the developmental transcription factor HoxC11. ChIP-sequencing of HoxC11 in LY2 cells shows where the transcription factor binds throughout the genome.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
3 Samples
Download data: BIGWIG
Series
Accession:
GSE54027
ID:
200054027
6.

SRC-1 targets ADAM22: an ER-independent mechanism of tumour progression in endocrine resistance

(Submitter supplied) We profile the binding of Steroid Receptor Co-activator (SRC1) in LY2 cells, a tamoxifen-resistant cell line, in the presence and absence of tamoxifen using ChIP-sequencing technology. The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid-independent tumour. The p160 steroid coactivataor protein SRC-1, through interactions with developmental proteins and other non-steroidal transcription factors, drives this tumour adaptability. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL9115
3 Samples
Download data: MAP, WIG
Series
Accession:
GSE28987
ID:
200028987
7.

SRC1 gene regulation in endocrine resistant breast cancer cells

(Submitter supplied) The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid independent tumour. The p160 steroid coactivator protein SRC-1, through interactions with developmental proteins and other non-steroidal transcription factors drives this tumour adaptability. Here, using discovery studies we identify ADAM22, a non-protease member of the ADAMs family, as a direct target of SRC-1, independent of estrogen receptor(ER). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4095
Platform:
GPL570
14 Samples
Download data: CEL
Series
Accession:
GSE28645
ID:
200028645
8.
Full record GDS4095

Tamoxifen effect on SRC-1-deficient endocrine-resistant breast cancer cell line LY2

Analysis of endocrine-resistant LY2 breast cancer cells depleted of p160 steroid coactivator protein SRC-1 and treated with tamoxifen. SRC-1 is central to the development of the endocrine resistant phenotype. Results provide insight into the molecular basis of endocrine resistant breast cancer.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE28645
14 Samples
Download data: CEL
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