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Links from GEO DataSets

Items: 15

1.
Full record GDS5430

Ethanol effect on lymphoblastoid cell lines from alcoholics

Analysis of lymphoblastoid cell lines (LCLs), obtained from alcoholics, after treatment with ethanol in vitro. Results provide insight into the feasibility of using LCLs to study the molecular consequences of exposure to alcohol.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 disease state, 2 gender, 42 individual sets
Platform:
GPL570
Series:
GSE52553
84 Samples
Download data: CEL, CHP
2.

Human post-mortem brain gene expression from various brain regions from alcoholic and non-alcoholic subjects

(Submitter supplied) 4 samples from 9 brain regions Brain tissue from the New South Wales Tissue Resource Centre, 9 brain regions, 4 samples each: 1 male alcoholic, 1 female alcoholic, 1 male control, 1 female control. Brain regions: pre-frontal cortex, cerebral cortex, visual cortex, thalamus, hippocampus, amygdala, caudate nucleus, putamen, cerebellum
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
36 Samples
Download data: CEL
Series
Accession:
GSE121497
ID:
200121497
3.

Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression

(Submitter supplied) Compared gene expression in lymphoblasoid cell lines from alcholics and controls and 24 hr treatment with ethanol. To elucidate the effects of a controlled exposure to ethanol on gene expression, we studied lymphoblastoid cell lines (LCLs) from 21 alcoholics and 21 controls. We cultured each cell line for 24 h with and without 75 mM ethanol and measured gene expression using microarrays. Differences in expression between LCL from alcoholics and controls were modest, but included 13 genes previously identified as associated with alcoholism or related traits in one or more GWAS, including KCNA3, DICER1, ZNF415, Catalase and PPARGC1B. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5430
Platform:
GPL570
84 Samples
Download data: CEL, CHP
Series
Accession:
GSE52553
ID:
200052553
4.

ETHANOL ACTIVATES IMMUNE RESPONSE IN LYMPHOBLASTOID CELLS

(Submitter supplied) The short term effects of alcohol on gene expression in brain tissue cannot directly be studied in humans. Because neuroimmune signaling is altered by alcohol, immune cells are a logical, accessible choice to study and might provide biomarkers. RNAseq was used to study the effects of 48 h exposure to ethanol on lymphoblastoid cell lines (LCLs) from 20 alcoholics and 20 controls. Ethanol exposure resulted in differential expression of 4,577 of the 12,526 genes detectably expressed in the LCLs (FDR ≤ 0.05); 55% of these showed increased expression. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16558
80 Samples
Download data: TXT
Series
Accession:
GSE126329
ID:
200126329
5.

Stress-response pathways are altered in the hippocampus of chronic alcoholics.

(Submitter supplied) Comparison of gene expression in post-mortem hippocampus from 20 alcoholics and 19 controls. The chronic high-level alcohol consumption seen in alcoholism leads to dramatic effects on the hippocampus, including decreased white matter, loss of oligodendrocytes and other glial cells, and inhibition of neurogenesis. Examining gene expression in post mortem hippocampal tissue from 20 alcoholics and 19 controls allowed us to detect differentially expressed genes that may play a role in the risk for alcoholism or whose expression is modified by chronic consumption of alcohol. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4879
Platform:
GPL6244
39 Samples
Download data: CEL
Series
Accession:
GSE44456
ID:
200044456
6.
Full record GDS4879

Chronic high-level alcohol consumption effect on brain: post-mortem hippocampus

Analysis of post-mortem hippocampus of chronic alcoholics (CAs). Chronic high-level alcohol consumption leads to decreased white matter and inhibition of neurogenesis. Results provide insight into molecular mechanisms that may play a role in the risk for alcoholism.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 2 gender sets
Platform:
GPL6244
Series:
GSE44456
39 Samples
Download data: CEL
7.

Human Variation Panel: Gene Expression and Genotype

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array; Expression profiling by array; Genome variation profiling by SNP array
4 related Platforms
862 Samples
Download data: CEL
Series
Accession:
GSE24277
ID:
200024277
8.

Genome-wide SNP array data from Human Variation Panel by Illumina 650K

(Submitter supplied) Radiation therapy is used to treat half of all cancer patients. Response to radiation therapy varies widely among patients. Therefore, we performed a genome-wide association study (GWAS) to identify biomarkers to help predict radiation response using 277 ethnically defined human lymphoblastoid cell lines (LCLs). Basal gene expression levels (Affymetrix) and 1.3 million genome-wide SNP markers (Illumina) were assayed for all 277 human LCLs. more...
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platform:
GPL6987
95 Samples
Download data: CSV
Series
Accession:
GSE24274
ID:
200024274
9.

Genome-wide SNP array data from Human Variation Panel by Illumina 550K

(Submitter supplied) Radiation therapy is used to treat half of all cancer patients. Response to radiation therapy varies widely among patients. Therefore, we performed a genome-wide association study (GWAS) to identify biomarkers to help predict radiation response using 277 ethnically defined human lymphoblastoid cell lines (LCLs). Basal gene expression levels (Affymetrix) and 1.3 million genome-wide SNP markers (Illumina) were assayed for all 277 human LCLs. more...
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platform:
GPL6434
192 Samples
Download data: CSV
Series
Accession:
GSE24260
ID:
200024260
10.

Genome-wide SNP array data from Human Variation Panel by Illumina 510S

(Submitter supplied) Radiation therapy is used to treat half of all cancer patients. Response to radiation therapy varies widely among patients. Therefore, we performed a genome-wide association study (GWAS) to identify biomarkers to help predict radiation response using 277 ethnically defined human lymphoblastoid cell lines (LCLs). Basal gene expression levels (Affymetrix) and 1.3 million genome-wide SNP markers (Illumina) were assayed for all 277 human LCLs. more...
Organism:
Homo sapiens
Type:
SNP genotyping by SNP array; Genome variation profiling by SNP array
Platform:
GPL6988
288 Samples
Download data: CSV
Series
Accession:
GSE24245
ID:
200024245
11.

Basal gene expression data from Human Variation Panel

(Submitter supplied) We used microarrays to identify the variation of basal gene expression level among 287 lymphoblastoid cell lines. Radiation therapy is used to treat half of all cancer patients. Response to radiation therapy varies widely among patients. Therefore, we performed a genome-wide association study (GWAS) to identify biomarkers to help predict radiation response using 277 ethnically defined human lymphoblastoid cell lines (LCLs). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
287 Samples
Download data: CEL
Series
Accession:
GSE23120
ID:
200023120
12.

Transcriptional alterations in cycling neural stem cells underlying alcohol use disorders

(Submitter supplied) Ethanol inhibits the proliferation of neural stem cells in the fetal, adolescent, and adult brain. The consequences are cognitive deficits associated with fetal alcohol spectrum disorder and alcohol use disorder. We tested the hypothesis that ethanol affects progression through cell cycle checkpoints by differentially modifying transcriptional processes. Monolayer cultures of NS-5 neural stem cells were treated for 48 hr with the mitogenic agent FGF2 or the anti-mitogenic TGFβ1 in the absence or presence of ethanol. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, CHP
Series
Accession:
GSE19436
ID:
200019436
13.

Gene expression analysis in absence epilepsy using a monozygotic twin design

(Submitter supplied) Objective: To identify genes involved in idiopathic absence epilepsies by analysing gene expression using a monozygotic (MZ) twin design. Methods: Genome-wide gene expression in lymphoblastoid cell lines was determined using microarrays derived from five discordant and four concordant MZ twin pairs with idiopathic absence epilepsies and five unaffected MZ twin pairs. Gene expression was analysed using three strategies: discordant MZ twins were compared as matched pairs, MZ twins concordant for epilepsy were compared to control MZ twins, and a singleton design of affected versus unaffected MZ twin individuals was used irrespective of twin pairing. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
30 Samples
Download data: CEL, CHP
Series
Accession:
GSE7486
ID:
200007486
14.

Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

(Submitter supplied) Alcoholism is a complex disorder determined by interactions between genetic and environmental risk factors. Drosophila represents a powerful model system to dissect the genetic architecture of alcohol sensitivity, as large numbers of flies can readily be reared in defined genetic backgrounds and under controlled environmental conditions. Furthermore, flies exposed to ethanol undergo physiological and behavioral changes that resemble human alcohol intoxication, including loss of postural control, sedation, and development of tolerance. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Dataset:
GDS3072
Platform:
GPL1322
24 Samples
Download data: CEL, CHP
Series
Accession:
GSE7614
ID:
200007614
15.
Full record GDS3072

Alcohol sensitivity model

Analysis of alcohol resistant and sensitive strains. Strains generated by artificial selection for alcohol sensitivity over multiple generations. Results provide insight into the molecular basis of alcohol sensitivity.
Organism:
Drosophila melanogaster
Type:
Expression profiling by array, count, 2 gender, 2 other, 3 strain sets
Platform:
GPL1322
Series:
GSE7614
24 Samples
Download data: CEL, CHP
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