Similar studies for GEO DataSets (Select 5438) - GEO DataSets

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Items: 12

Select item 54381.

Lung from cigarette smoke-related chronic obstructive pulmonary disease model: time course

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 age, 2 stress sets

Platform:: GPL6885
Series:: GSE52509
12 Samples

Download data

DataSet

Accession:: GDS5438

ID:: 5438

Select item 2000525092.

Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is characterized by a progressive decline in lung function, caused by exposure to exogenous particles, mainly cigarette smoke (CS). COPD pathogenesis is initiated and perpetuated by an abnormal CS-induced inflammatory response of the lungs, involving both innate and adaptive immunity. Specifically, B cells organized in iBALT structures, as well as macrophages, accumulate in the lungs and contribute to CS-induced emphysema, but the mechanisms thereof remain unclear. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5438
Platform:: GPL6885
12 Samples

Download data: TXT

Series

Accession:: GSE52509

ID:: 200052509

Select item 2000493733.

Expression data from the lungs of Scnn1b-Transgenic and wild-type mice

(Submitter supplied) Airway mucus obstruction triggers macrophage activation and MMP12-dependent emphysema

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL

Series

Accession:: GSE49373

ID:: 200049373

Select item 2001192574.

The non-canonical Notch ligand DNER regulates IFNγ in macrophages during COPD progression

(Submitter supplied) Chronic Obstructive Pulmonary Diseases (COPD) is the third leading cause of death worldwide with no curative therapy available. A novel non-canonical Notch ligand, DNER, has been identified in a GWAS to correlate with disease severity, but its function and contribution to COPD is completely unknown. DNER localization and expression was determined in COPD patients and 6 month cigarette smoke (CS)-exposed mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
18 Samples

Download data: CEL

Series

Accession:: GSE119257

ID:: 200119257

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000335125.

Gene expression data on lungs of wild-type and Rora (Retinoic acid related orphan receptor) mutant mice exposed to room air and smoke

(Submitter supplied) Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE33512

ID:: 200033512

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000938986.

MMP28 is a key contributor to emphysema pathogenesis

(Submitter supplied) Chronic Obstructive Pulmonary Disease, which is comprised of chronic bronchitis and emphysema, is a leading cause of morbidity and mortality. Because tissue destruction is the prominent characteristic of emphysema, extracellular proteinases, particularly those with elastolytic ability, are often considered to be key drivers in this disease. Several human and mouse studies have implicated roles for matrix metalloproteinases (MMPs), particularly macrophage-derived proteinases, in COPD pathogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
16 Samples

Download data: TXT

Series

Accession:: GSE93898

ID:: 200093898

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000570737.

Irp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading

(Submitter supplied) Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death globally, is influenced by both cigarette smoking and genetic determinants. We have previously identified iron-responsive element binding protein 2 (IRP2) as a candidate COPD susceptibility gene based on genetic association studies, with IRP2 increased in the lungs of COPD patients. Here we demonstrate that mice deficient in IRP2 are protected from cigarette smoke (CS)-induced COPD. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE57073

ID:: 200057073

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000570488.

Irp2 mediates cigarette smoke-induced bronchitis and emphysema via regulation of cytochrome c oxidase and mitochondrial iron loading.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL17777
11 Samples

Download data: CEL

Series

Accession:: GSE57048

ID:: 200057048

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001376539.

polyA+ RNA sequencing on FACS sorted alveolar macrophages (CD45+SiglecF+CD11c+) from air and cigarette-smoke exposed wild type and miR-155 KO mice

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) is a highly prevalent respiratory disease characterized by airflow limitation and chronic inflammation. MiR-155 is described as an ancient regulator of the immune system. Our objective was to establish a role for miR-155 in cigarette smoke (CS)-induced inflammation and COPD. We demonstrate increased miR-155 expression by RT-qPCR in lung tissue of smokers without airflow limitation and patients with COPD compared to never smokers and in lung tissue and alveolar macrophages of CS-exposed mice compared to air-exposed mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
20 Samples

Download data: TXT

Series

Accession:: GSE137653

ID:: 200137653

PubMed Similar studies SRA Run Selector

Select item 20008784210.

Role of Gq/11 and G12/13 signalling in Type II alveolar epithelial cells

(Submitter supplied) We have used microarrays to identify individual genes and pathways regulated by Gq/11 or G12/13 signalling in type II alveolar epithelial cells isolated from the lungs of knockout mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE87842

ID:: 200087842

Select item 20003451711.

Cigarette smoking alters mRNA expression in human alveolar macrophages

(Submitter supplied) Alveolar macrophages from never smokers and active smokers were isolated by bronchoalveolar lavage and gene expression was measured. Chronic cigarette smoke exposure, as occurs in smoker's lungs, leads to significant changes in gene expression. Of note, RNA was isolated immediately following bronchoscopy. Alveolar macrophage levels were >95%.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
8 Samples

Download data: CEL

Series

Accession:: GSE34517

ID:: 200034517

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008233512.

Diesel exhaust particle (DEP)-treated HBE cells

(Submitter supplied) We evaluated the profile of lncRNA and mRNA expression in control and 50μg/ml DEP treated HBE cells using the Arraystar Human LncRNA Array v3.0 array,7th generation. Our findings implicates that dysregulation of mitochondria invovled mRNAs may play important role in cytotoxicity of DEP.