Similar studies for GEO DataSets (Select 5439) - GEO DataSets

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Items: 3

Select item 54391.

Mutant HLA-F-adjacent transcript 10 overexpression effect on HCT116 colon cancer cell line

Analysis of HCT116 cells expressing wildtype HLA-F-adjacent transcript 10 (FAT10) or FAT10 mutants with mutations at mitotic arrest-deficient 2 (MAD2)-binding region 1 (M1), region 2 (M2), or at both regions (M12). Results assess the molecular effects of abrogating the FAT10-MAD2 interaction.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 5 genotype/variation sets

Platform:: GPL10558
Series:: GSE54167
10 Samples

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DataSet

Accession:: GDS5439

ID:: 5439

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000541672.

Disruption of FAT10-MAD2 binding inhibits tumor progression

(Submitter supplied) FAT10 interacts with MAD2 and caused tumor progression. The hypothesis tested in the present study was FAT10 induces tumor progression through its binding to MAD2 and Disruption of this binding restored its global gene expression

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5439
Platform:: GPL10558
10 Samples

Download data: TXT

Series

Accession:: GSE54167

ID:: 200054167

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001206413.

Gene expression profiling of aneuploid IMR90 cells induced by Rb, DNMT1 and MAD2 depletion

(Submitter supplied) Segregation errors of chromosomes into daughter cells lead to aneuploidy that is considered a major feature of solid tumors. How diploid cells face chromosome mal-segregation and the mechanisms driving aneuploidy tolerance in tumor cells are not yet completely defined. Thus, an important goal in cancer genetics is to identify gene networks leading to aneuploidy as well involved in its tolerance. To this aim we induced aneuploidy in IMR90 human primary cells and analyzed their gene expression profiles by DNA microarrays. more...