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Links from GEO DataSets

Items: 20

1.
Full record GDS5473

Short-term fasting effect on skeletal muscle: time course

Analysis of skeletal muscle biopsies collected at 1.5, 4, 10, and 24hr post-meal time from healthy young men subjected to a 24hr fast. Results provide insight into the molecular mechanisms underlying metabolic adaptation to fasting in healthy humans.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 12 individual, 4 time sets
Platform:
GPL10558
Series:
GSE55924
48 Samples
Download data
DataSet
Accession:
GDS5473
ID:
5473
2.

Regulation of skeletal muscle energy/nutrient-sensing pathways during metabolic adaptation to fasting in healthy humans

(Submitter supplied) The aim of the study was to investigate how short-term fasting affects whole-body energy homeostasis and skeletal muscle energy/nutrient-sensing pathways and transcriptome in humans. For this purpose, twelve young healthy men were studied during a 24-hour fast. Skeletal muscle biopsies were collected and analyzed at baseline and after 4, 10 and 24h of fasting. As expected, fasting induced a time-dependent decrease in plasma insulin and leptin levels, whereas levels of ketone bodies and free fatty acids increased. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS5473
Platform:
GPL10558
48 Samples
Download data: TXT
Series
Accession:
GSE55924
ID:
200055924
3.

Regulation of Energy Metabolism and Mitochondrial Biogenesis Independently from the SIRT1-PGC1a Pathway in Human Skeletal Muscle during Lipid Overfeeding

(Submitter supplied) The adaptive mechanisms in response to excess energy supply are still poorly known in humans. Our aims were to define metabolic responses and changes in gene expression in skeletal muscle of healthy volunteers during fat overfeeding.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
24 Samples
Download data: CEL
Series
Accession:
GSE50484
ID:
200050484
4.

Regulation of Glucose Uptake and Inflammation by FOXO1 and FOXO3 in Skeletal Muscle

(Submitter supplied) Forkhead box class O (FoxO) transcription factors regulate whole body energy metabolism, skeletal muscle mass and substrate switching. To elucidate the role of FOXO in skeletal muscle, dominant negative (dn) constructs for FOXO1 (FOXO1dn) or FOXO3 (FOXO3dn) were transfected by electroporation into mouse tibialis anterior muscle and glucose uptake, signal transduction, and glucose stimulated gene expression profiles were assessed. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL17400
24 Samples
Download data: CEL
Series
Accession:
GSE105778
ID:
200105778
5.

Genome-wide Analysis of Class IIa Histone Deacetylase Regulation of Hepatic Gluconeogenesis

(Submitter supplied) Analysis of Class II Histone Deacetylase (HDAC) regulation of hepatic gluconeogenesis at the gene expression level. We show that in liver, Class IIa HDACs (HDAC4, 5, and 7) are all phosphorylated and excluded from the nucleus by AMPK family kinases. In response to the fasting hormone glucagon, Class IIa HDACs rapidly translocate to the nucleus where they directly bind to the promoters of gluconeogenic enzymes such as G6Pase. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6103
16 Samples
Download data: TXT
Series
Accession:
GSE20979
ID:
200020979
6.

Circadian transcriptome in mouse skeletal muscle after exercise in the early rest versus active phase

(Submitter supplied) We performed the circadian transcriptome analysis using the skeletal muscle from sedentary and exercised mice either in the early rest phase (ZT3) or in the early active phase (ZT15). By the combination with circadian transcriptomic and metabolomic analysis, we revealed time-of-day-dependent remodeling of circadian muscular metabolic pathways involved in glucose and glycerol metabolism after exercise. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
140 Samples
Download data: TXT
Series
Accession:
GSE126962
ID:
200126962
7.

Circadian misalignment induces fatty acid metabolism gene profiles and induces insulin resistance in human skeletal muscle.

(Submitter supplied) Circadian misalignment, such as in shift work, has been associated with obesity and type 2 diabetes, however, direct effects of circadian misalignment on skeletal muscle insulin sensitivity and muscle molecular circadian clock have never been investigated in humans. Here we investigated insulin sensitivity and muscle metabolism in fourteen healthy young lean men (age 22.4 ± 2.8 years; BMI 22.3 ± 2.1 kg/m2 [mean ± SD]) after a 3-day control protocol and a 3.5-day misalignment protocol induced by a 12-h rapid shift of the behavioral cycle. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17692
47 Samples
Download data: CEL
Series
Accession:
GSE106800
ID:
200106800
8.

Transcriptional response of rat skeletal muscle to prolonged fasting

(Submitter supplied) Prolonged fasting-induced changes in rat tibialis anterior muscle transcriptome Skeletal muscle is of primary importance for metabolism, thermogenesis and locomotion. However, muscle integrity is inevitably challenged throughout life, and muscle atrophy occurs in various situations, being associated with development of metabolic diseases. There is virtually no fully effective countermeasure today to fight the loss of muscle mass. more...
Organism:
Rattus norvegicus
Type:
Expression profiling by array
Platform:
GPL6247
9 Samples
Download data: CEL, CHP
Series
Accession:
GSE149829
ID:
200149829
9.

Temporal RNA-seq analysis of human skeletal myotubes synchronized in vitro

(Submitter supplied) The circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchronized in vitro. Extensive rhythmic transcription was observed in human skeletal muscle in comparison to in vitro cell culture. However, nearly half of the in vivo rhythmicity was lost at the mRNA accumulation level. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
100 Samples
Download data: TXT
Series
Accession:
GSE109825
ID:
200109825
10.

Transcriptomic analyses reveal rhythmic and CLOCK-driven pathways in human skeletal muscle 

(Submitter supplied) The circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchronized in vitro. Extensive rhythmic transcription was observed in human skeletal muscle in comparison to in vitro cell culture. However, nearly half of the in vivo rhythmicity was lost at the mRNA accumulation level. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL16791
57 Samples
Download data: TXT
Series
Accession:
GSE108539
ID:
200108539
11.

Metabolic syndrome exercise training

(Submitter supplied) We assessed vastus lateralis muscle gene expression levels of 12 women with the metabolic syndrome before and after a 6 month exercise training program
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS4909
Platform:
GPL6244
24 Samples
Download data: CEL
Series
Accession:
GSE43760
ID:
200043760
12.
Full record GDS4909

Exercise training effect on metabolic syndrome patients: vastus lateralis muscle

Analysis of skeletal muscle from metabolic syndrome (MS) female patients before and after 6 months of exercise training. MS is associated with insulin resistance. Results provide insight into the molecular mechanisms underlying insulin-resistant skeletal muscle in MS patients.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 2 disease state, 12 individual, 2 protocol sets
Platform:
GPL6244
Series:
GSE43760
24 Samples
Download data: CEL
DataSet
Accession:
GDS4909
ID:
4909
13.

META-PREDICT: Dynamic responses of the global human skeletal muscle coding and noncoding transcriptome to exercise

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL28991 GPL24047 GPL28993
1257 Samples
Download data: CEL
Series
Accession:
GSE154846
ID:
200154846
14.

DERBY BBSRC RET Study: Impact of resistance exercise on human skeletal muscle gene expression

(Submitter supplied) The aim of this work was to produce a molecular signature of human muscle responses to supervised resistance training and examine how such a profile relates to established aerobic exercise adaptation gene networks.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
89 Samples
Download data: CEL
Series
Accession:
GSE47881
ID:
200047881
15.

The Heritage (HEalth, RIsk factors, exercise Training And GEnetics) family study

(Submitter supplied) The overall objective of the heritage project is to study the role of the genotype in cardiovascular,metabolic and hormonal responses to aerobic exercise training and the contribution of regular exercise to changes in several cardiovascular disease and diabetes risk factors. PLEASE NOTE THE POST-TRAINING GENE CHIP FILES HAVE NEVER BEEN RELEASED ON GEO. PLEASE ALSO NOTE THAT DUE TO THE OUTDATED INSULIN ASSAY UTILISED IN THE HERITAGE STUDY, THE INSULIN DATA WAS NOT COMPARABLE WITH ANY MORE RECENT MODERN STUDIES.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
52 Samples
Download data: CEL
Series
Accession:
GSE47874
ID:
200047874
16.

Transcriptome profiling in human primary mitochondrial respiratory chain disease

(Submitter supplied) Primary mitochondrial respiratory chain (RC) diseases are heterogeneous in etiology and manifestations but collectively impair cellular energy metabolism. To identify a common cellular response to RC disease, systems biology level transcriptome investigations were performed in human RC disease skeletal muscle and fibroblasts. Global transcriptional and post-transcriptional dysregulation in a tissue-specific fashion was identified across diverse RC complex and genetic etiologies. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16240
53 Samples
Download data: CEL
Series
Accession:
GSE42986
ID:
200042986
17.

Transcriptome signature of white adipose tissue, liver, and skeletal muscle in 24 hours fasted mice (C57Bl/6J)

(Submitter supplied) Fasting is the process of metabolic adaption to food deprivation that is taking place in most organisms, e.g. during the daily resting phase in mammals. Furthermore, in biomedical research fasting is used in most metabolic studies to synchronize nutritional states of study subjects. Because there is a lack of standardization for this procedure, we need a deeper understanding of the dynamics and the molecular players in fasting. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS4918
Platform:
GPL11533
30 Samples
Download data: CEL
Series
Accession:
GSE46495
ID:
200046495
18.
Full record GDS4918

Fasting effect on white adipose tissue, liver and skeletal muscle

Analysis of white adipose tissue, liver and skeletal muscle in 24h fasted C57Bl/6J males. Results provide insight into the molecular mechanisms underlying metabolic adaption to food deprivation in various tissues.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 protocol, 3 tissue sets
Platform:
GPL11533
Series:
GSE46495
30 Samples
Download data: CEL
19.

Interorgan coordination of the murine adaptive response to fasting

(Submitter supplied) The effects of fasting have been studied extensively, predominantly on isolated processes, within a specific organ. No comprehensive study of the adaptations was available for different organs, let alone interrelating them, which left the understanding of the body’s orchestration of fasting response limited. The gene expression profiles of brain, small intestine, kidney, liver and skeletal muscle were therefore studied in mice subjected to short, moderate and prolonged fasting. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS3893
Platform:
GPL11012
122 Samples
Download data: TXT
Series
Accession:
GSE24504
ID:
200024504
20.
Full record GDS3893

Fasting effect on multiple tissues: time course

Analysis of brain, small intestine, kidney, liver, and skeletal muscle subjected to 0-72 hrs of fasting. Adapting to starvation requires an interorgan integration of metabolic activity to protect vital organs. Results provide insight into molecular mechanisms underlying this adaptive response.
Organism:
Mus musculus
Type:
Expression profiling by array, log2 ratio, 5 time, 5 tissue sets
Platform:
GPL11012
Series:
GSE24504
122 Samples
Download data: TXT
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