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Links from GEO DataSets

Items: 9

1.
Full record GDS5503

Small molecule GW8510 effect on pancreatic beta cell

Analysis of pancreatic beta cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5502, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
2.

Expression data from GW8510 treatment of pancreatic cells

(Submitter supplied) Expression of insulin in terminally differentiated non-beta pancreatic cell types could be important for treating type-1 diabetes. We observed that the kinase inhibitor GW8510 up-regulated insulin expression in mouse pancreatic alpha cells. Gene-expression profiling and gene-set enrichment analysis of GW8510-treated alpha cells suggested coordinate up-regulation of the p53 pathway, which was further implicated in induction of insulin transcript.
Organism:
Mus musculus
Type:
Expression profiling by array
Datasets:
GDS5502 GDS5503
Platform:
GPL8321
12 Samples
Download data: CEL
Series
Accession:
GSE31102
ID:
200031102
3.
Full record GDS5502

Small molecule GW8510 effect on pancreatic alpha cell

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL8321
Series:
GSE31102
6 Samples
Download data: CEL
4.

Global microRNA profiling of aTC1-6 and bTC1 before and after treatment with cytokines

(Submitter supplied) The study sought to determine the global miRNA profiles of mouse pancreatic cell lines aTC1-6 and bTC1 at steady state and after treatment with a cocktail of pro-inflammatory cytokines (IL1b; IFNg and TNFa) for a time course of 24 and 48 hours. Inflammatory cocktail contains IL1b 50 IU/ml; IFNg 1000 IU/ml; TNFa 1000 IU/ml. MicroRNA expression profiles in both cell lines during the different experimental conditions were determined using TaqMan® Rodent miRNA A+B Cards Set v2.0 (TLDA, Life Technologies). more...
Organism:
Mus musculus
Type:
Other
Platform:
GPL11199
15 Samples
Download data: TXT
Series
Accession:
GSE42970
ID:
200042970
5.

Diabetes Remission Using Glucose-Responsive Insulin-Producing Human alpha-Cells

(Submitter supplied) Natural and stable cell identity switches, where terminally-differentiated cells convert into different cell-types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells become insulin expressers upon ablation of insulin-secreting β-cells, promoting diabetes recovery. Whether human islets also display this plasticity for reconstituting β-like cells, especially in diabetic conditions, remains unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
4 Samples
Download data: TXT
Series
Accession:
GSE123844
ID:
200123844
6.

Diabetes Remission Using Glucose-Responsive Insulin-Producing Human α-Cells

(Submitter supplied) Natural and stable cell identity switches, where terminally-differentiated cells convert into different cell-types when stressed, represent a widespread regenerative strategy in animals, yet they are poorly documented in mammals. In mice, some glucagon-producing pancreatic α-cells become insulin expressers upon ablation of insulin-secreting β-cells, promoting diabetes recovery. Whether human islets also display this plasticity for reconstituting β-like cells, especially in diabetic conditions, remains unknown. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
39 Samples
Download data: TXT
Series
Accession:
GSE117454
ID:
200117454
7.

Transcriptomic profiling of alpha, beta, and delta cell populations provides new insights into the role of ghrelin in the pancreas

(Submitter supplied) Intra-islet crosstalk between islet cells is critical in orchestrating the body’s response to changes in blood glucose levels, but is incompletely understood. In this study, we used transgenic mouse lines that allowed the purification and transcriptomic characterisation of alpha, beta, and delta cells, yielding an RNA-sequencing database that can be searched for regulatory proteins which are differentially expressed between cell types. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
15 Samples
Download data: TXT
Series
Accession:
GSE76017
ID:
200076017
8.

p53 binding and chromatin dynamics after etoposide treatment of primary lung fibroblast

(Submitter supplied) We report the chromatin modification dynamics at p53 binding sites afte 6 hours of treatment of etoposide (100 micromolar final) in IMR90 human lung fibroblasts using ChIP-seq , ATAC-seq, and polyA+ RNA-seq analyses. We assessed the genomewide occupancy of histone H3, H3K4me3, H3K4me2, H3K4me1, H3K27ac, H4K16ac, RNA polymerase II, p53, and transposase-accessible chromatin (ATAC-seq) in response to etoposide treatment.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL11154 GPL18573
11 Samples
Download data: BEDGRAPH
Series
Accession:
GSE115940
ID:
200115940
9.

Expression data from mouse pancreatic cell lines treated with chromatin-targeting small molecules

(Submitter supplied) We measured the genome-wide expression changes induced by 29 compounds targeting HDACs, DNMTs, histone lysine methyltransferases (HKMTs), and protein arginine methyltransferases (PRMTs) in pancreatic α- and β-cell lines. We used microarrays to detail the global programme of gene-expression changes induced by chromatin-targeting compounds at 1, 6, and 24 hours.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8759
594 Samples
Download data: CEL
Series
Accession:
GSE36379
ID:
200036379
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