Similar studies for GEO DataSets (Select 5519) - GEO DataSets

Select item 55191.

5-azacytidine effect on mesenchymal progenitor cell line

Analysis of C2C12 mesenchymal progenitor cells treated with 5-azacytidine (5AC). 5AC is a DNA methylation inhibitor and induces genomic demethylation. Results provide insight into the role of DNA demethylation on skeletal myotube maturation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL1261
Series:: GSE30192
6 Samples

Download data: CEL

DataSet

Accession:: GDS5519

ID:: 5519

Select item 2000301922.

Effect of 5-azacytidine on gene expression in C2C12 myoblasts

(Submitter supplied) Mesenchymal progenitor cells can be differentiated in vitro into myotubes that exhibit many characteristic features of primary mammalian skeletal muscle fibers. However, in general, they do not show the functional excitation-contraction coupling or the striated sarcomere arrangement typical of mature myofibers. Epigenetic modifications have been shown to play a key role in regulating the progressional changes in transcription necessary for muscle differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5519
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE30192

ID:: 200030192

Select item 2000220773.

MeDIP-on-chip and Pol-II ChIP-on-chip during C2C12 myogenic and BMP2-induced osteogenic differentiation

(Submitter supplied) Differentiation of pluripotent embryonic stem cells, via more restricted multipotent adult stem cells, towards the multitude of terminally differentiated, specialized cell types that make up the adult body is a multi-step process characterized by a progressive restriction of differentiation potential. Previous studies have demonstrated tissue-specific differences in DNA methylation patterns that might play a role in lineage restriction and tissue-specific gene expression. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by genome tiling array; Methylation profiling by genome tiling array

Platform:: GPL5811
14 Samples

Download data: BAR, BED, CEL

Series

Accession:: GSE22077

ID:: 200022077

PubMed Similar studies

Select item 2001486674.

Culturing C2C12 myotubes on micromolded gelatin hydrogels accelerates myotube maturation

(Submitter supplied) We report that differentiation of the C2C12 myoblast line on patterened hydrogels results in the increased expression of muscle sarcomere genes and more closely models expression changes that happen in in vivo muscle differentiation than do C2C12 myoblasts cultured on unpatterened substrates.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
30 Samples

Download data: TSV

Series

Accession:: GSE148667

ID:: 200148667

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000650375.

Deconstruction of DNA methylation patterns during myogenesis reveals specific epigenetic events in the establishment of the skeletal muscle lineage

(Submitter supplied) Cellular differentiation involves widespread epigenetic reprogramming, including modulation of DNA methylation patterns. We have investigated DNA genome-wide methylation dynamics in embryonic stem cells, primary myoblasts, terminal differentiated myotubes and mature myofibers. About 1.000 differentially methylated regions (DMRs) have been indentified during muscle-lineage determination and terminal differentiation. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL9250
23 Samples

Download data: TAB

Series

Accession:: GSE65037

ID:: 200065037

PubMed Similar studies SRA Run Selector

Select item 2000418776.

Transcriptional analysis of genes regulating the mitochondrial dNTP pool in muscle cells.

(Submitter supplied) Mutations in genes involved in dNTP metabolism can lead to tissue-specific mitochondrial depletion syndromes (MDS), likely because the expression of key enzymes is reduced to critical levels in post mitotic cells. Our goal was to establish an in vitro skeletal muscle cell model to study the muscle specificity of MDS associated with mitochondrial dNTP pool imbalance. We performed a comprehensive analysis at the mRNA level of enzymes and transporters responsible for dNTP pool imbalance in muscle cells in vitro and in vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE41877

ID:: 200041877

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000877497.

An electrical pulse stimulation protocol to study acute epigenetic response to muscle cell contraction uncovers acute hydroxymethylation of the exercise-responsive gene Nr4a3

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16417 GPL16791
56 Samples

Download data

Series

Accession:: GSE87749

ID:: 200087749

PubMed Full text in PMC Similar studies

Select item 2000877488.

An electrical pulse stimulation protocol to study acute epigenetic response to muscle cell contraction uncovers acute hydroxymethylation of the exercise-responsive gene Nr4a3 [RNA-Seq]

(Submitter supplied) Physical exercise triggers numerous positive adaptations through the regulation of genes controlling muscle structure and function. Epigenetic factors like DNA methylation participate in transcriptional activation by allowing the recruitment of the transcription machinery to gene promoters. Exercise induces dynamic DNA demethylation at gene promoters, but the contribution of the demethylation precursor hydroxymethylcytosine is unknown. more...