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Items: 20

1.
Full record GDS5602

Transcription factor Inhibitor of differentiation 3 knockout effect on invariant natural killer T cells: developmental time course

Analysis of stage 1 (Tet+CD24-CD44-NK1.1-) and stage 2 (Tet+CD24-CD44+NK1.1-) invariant natural killer T (iNKT) cells FACS-sorted from inhibitor of differentiation 3 (Id3) knockout thymus. Results provide insight into the role of transcriptional regulator ID3 during iNKT cell maturation in thymus.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 cell type, 2 development stage, 2 genotype/variation sets
Platform:
GPL1261
Series:
GSE50933
10 Samples
Download data: CEL
2.

Essential functions for ID proteins at multiple checkpoints in natural killer T cell development

(Submitter supplied) Thymic iNKT cell development is divided into four stages (stage 0-3) that are characterised, in C57BL/6 mouse strain, by the differential expression of surface markers, such as CD24, CD44 and NK1.1. During transition from immature to mature iNKT cell subsets, gene expression is tightly regulated. Here, we used microarray analysis to detail the influence of the transcriptional regulator ID3 during iNKT cell maturation in the thymus.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5602
Platform:
GPL1261
10 Samples
Download data: CEL
Series
Accession:
GSE50933
ID:
200050933
3.

Gene expression in neonatal NKT cells and lymphoma samples from mice with high E protein levels

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Expression profiling by array; Third-party reanalysis
Platforms:
GPL8321 GPL21103
8 Samples
Download data: CEL
Series
Accession:
GSE83761
ID:
200083761
4.

Gene expression in neonatal NKT cells and lymphoma samples from mice with high E protein levels [RNA-Seq]

(Submitter supplied) Inhibitor of DNA binding proteins (ID), including Id1-4, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins have been widely reported to be associated with a broad spectrum of tumors, recent studies have identified that Id3 also plays a tumor suppressor role in the development of Burkitt’s lymphoma in humans and Hepatosplenic T cell lymphomas in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
2 Samples
Download data: XLSX
Series
Accession:
GSE83760
ID:
200083760
5.

Gene expression in neonatal NKT cells and lymphoma samples from mice with high E protein levels [Microarray Expression]

(Submitter supplied) Inhibitor of DNA binding proteins (ID), including Id1-4, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins have been widely reported to be associated with a broad spectrum of tumors, recent studies have identified that Id3 also plays a tumor suppressor role in the development of Burkitt’s lymphoma in humans and Hepatosplenic T cell lymphomas in mice. more...
Organism:
Mus musculus
Type:
Expression profiling by array; Third-party reanalysis
Platform:
GPL8321
6 Samples
Download data: CEL, TXT
Series
Accession:
GSE73864
ID:
200073864
6.

A comparison of the transcriptional profiles of invariant NKT cells derived from Wild type and Eomes conditional knockout mice

(Submitter supplied) Functional subsets of iNKT cells, NKT1, NKT2 and NKT17, have been reported to arise during the thymus to peripheral differentiation stages. The key transcription factors for NKT1, NKT2 and NKT17 development in the thymus have been identified as T-bet, Gata3 and Rorγt, respectively. In contrast, these iNKT cell subsets can also undergo further differentiation in the periphery. Eomesodermin (Eomes) is a T-box transcription factor with high homology to T-bet and is expressed by activated CD8+ T cells as well as in resting and activated NK cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
18 Samples
Download data: TXT
Series
Accession:
GSE128069
ID:
200128069
7.

Id proteins suppress E2A-driven iNKT cell development prior to TCR selection [RNA-seq_new]

(Submitter supplied) Id proteins have been shown to promote the differentiation of conventional αβ and γδT cells, and to suppress the expansion of invariant Natural Killer T (iNKT) cells and innate-like γδNKT within their respective cell lineages. However, it remains to be determined whether Id proteins regulate lineage specification in developing T cells that give rise to these distinct cell fates. Here we report that in the absence of Id2 and Id3 proteins, E2A prematurely activates genes critical for the iNKT cell lineage prior to TCR expression. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
7 Samples
Download data: XLSX
Series
Accession:
GSE100601
ID:
200100601
8.

Id proteins suppress E2A-driven iNKT cell development prior to TCR selection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103
23 Samples
Download data: BED, WIG, XLSX
Series
Accession:
GSE89849
ID:
200089849
9.

Id proteins suppress E2A-driven iNKT cell development prior to TCR selection [RNA-seq]

(Submitter supplied) Id proteins have been shown to promote the differentiation of conventional αβ and γδT cells, and to suppress the expansion of invariant Natural Killer T (iNKT) cells and innate-like γδNKT within their respective cell lineages. However, it remains to be determined whether Id proteins regulate lineage specification in developing T cells that give rise to these distinct cell fates. Here we report that in the absence of Id2 and Id3 proteins, E2A prematurely activates genes critical for the iNKT cell lineage prior to TCR expression. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
12 Samples
Download data: XLSX
Series
Accession:
GSE89848
ID:
200089848
10.

Id proteins suppress E2A-driven iNKT cell development prior to TCR selection [ChIP-seq]

(Submitter supplied) Id proteins have been shown to promote the differentiation of conventional αβ and γδT cells, and to suppress the expansion of invariant Natural Killer T (iNKT) cells and innate-like γδNKT within their respective cell lineages. However, it remains to be determined whether Id proteins regulate lineage specification in developing T cells that give rise to these distinct cell fates. Here we report that in the absence of Id2 and Id3 proteins, E2A prematurely activates genes critical for the iNKT cell lineage prior to TCR expression. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: BED, WIG, XLSX
Series
Accession:
GSE89847
ID:
200089847
11.

Expression data from invariant natural killer T (iNKT) cells in spleen and adipose tissue

(Submitter supplied) Adipose tissue iNKT cells have different functions than iNKT cells in the blood and other organs. We used microarrays to detail the global gene expression profiles that might underlie these phenotypic and functional differences in adipose iNKT cells compared to splenic iNKT cells.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
2 Samples
Download data: CEL
Series
Accession:
GSE63358
ID:
200063358
12.

Mature thymic NKT and T cells

(Submitter supplied) Invariant Natural killer T (iNKT) cells are a separate lineage of T lymphocytes with innate effector functions. They express an invariant TCR specific for lipids presented by CD1d and their development and effector differentiation rely on a unique gene expression program. We asked whether this program includes microRNAs, small non-coding RNAs that regulate gene expression posttranscriptionally and play key role in the control of cellular differentiation programs. more...
Organism:
Human polyomavirus 1; Homo sapiens; Human alphaherpesvirus 1; Human betaherpesvirus 5; Macaca mulatta polyomavirus 1; Rattus norvegicus; Murid gammaherpesvirus 4; Mus musculus; Murid betaherpesvirus 1; Human gammaherpesvirus 4; JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8
Type:
Non-coding RNA profiling by array
Platform:
GPL7723
6 Samples
Download data: PDF, TXT
Series
Accession:
GSE15925
ID:
200015925
13.

Transnuclear mice reveal a population of Peyer’s patch iNKT cells that regulate B cell class switching to IgG1

(Submitter supplied) Tissue resident iNKT cells maintain tissue homeostasis and peripheral surveillance against pathogens; however, studying these cells is challenging due to low abundance and poor recovery from tissues. To increase the number of tissue resident iNKT cells, we used transnuclear mice cloned from iNKT nuclei. We detected iNKT cells from tissues where they are rare, including adipose, lung, skin-draining lymph nodes, and a previously undescribed population in Peyer’s patches (PP). more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: CSV
Series
Accession:
GSE129366
ID:
200129366
14.

NKT, CD1d-aGC+ Va24-, and CD4 T cell clones from human peripheral blood

(Submitter supplied) Microarray analysis was performed to determine the transcriptional profiles of NKT, CD1d-aGC+ Va24-, and CD4 T cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
28 Samples
Download data: CEL, CHP
Series
Accession:
GSE28726
ID:
200028726
15.

Transcriptome and Chromatin Landscape of iNKT Cells are Shaped by Subset Differentiation and Antigen Exposure

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
171 Samples
Download data
Series
Accession:
GSE161492
ID:
200161492
16.

Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure [ATAC-seq]

(Submitter supplied) Invariant natural killer T cells (iNKT cells) differentiate into thymic NKT1, NKT2 and NKT17 subsets that are also peripheral. We determined if the gene programs associated with these thymic subsets were maintained in peripheral sites, the influence of tissue location, and if there were large-scale changes after antigen exposure. RNA-seq and ATAC-seq analyses showed that iNKT cells in any subset were similar, regardless of tissue location. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
53 Samples
Download data: TSV
Series
Accession:
GSE161491
ID:
200161491
17.

Transcriptome and Chromatin Landscape of iNKT Cells are Shaped by Subset Differentiation and Antigen Exposure [RNA-seq]

(Submitter supplied) Invariant natural killer T cells (iNKT cells) differentiate into thymic NKT1, NKT2 and NKT17 subsets that are also peripheral. We determined if the gene programs associated with these thymic subsets were maintained in peripheral sites, the influence of tissue location, and if there were large-scale changes after antigen exposure. RNA-seq and ATAC-seq analyses showed that iNKT cells in any subset were similar, regardless of tissue location. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL24247
118 Samples
Download data: TSV
Series
Accession:
GSE157225
ID:
200157225
18.

PLZF acetylation levels regulate NKT cell differentiation

(Submitter supplied) The transcription factor PLZF (promyelocytic leukemia zinc finger) is encoded by the BTB 42 domain-containing 16 (Zbtb16) gene. Its repressor function regulates specific transcriptional 43 programs. During the development of invariant natural killer T (NKT) cells, PLZF is 44 expressed and directs their effector program but the detailed mechanisms underlying PLZF 45 regulation of multi-stage NKT cell developmental program are not well understood. more...
Organism:
Mus musculus
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL17021
4 Samples
Download data: TXT
Series
Accession:
GSE171984
ID:
200171984
19.

UTX controls lineage-specific epigenetic program of iNKT cells

(Submitter supplied) NKT cells are innate-like lymphocytes that protect against infection, autoimmune disease, and cancer. However, little is known about epigenetic regulation of iNKT cell development. Here, we show that the H3K27me3 histone demethylase UTX is an essential cell-intrinsic factor that controls an iNKT lineage specific gene expression program and epigenetic landscape in a demethylase activity dependent manner. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
9 Samples
Download data: BW
Series
Accession:
GSE84238
ID:
200084238
20.

UTX controls lineage-specific epigenetic program of iNKT cells

(Submitter supplied) iNKT cells are innate-like lymphocytes that protect against infection, autoimmune disease, and cancer. However, little is known about epigenetic regulation of iNKT cell development. Here, we show that the H3K27me3 histone demethylase UTX is an essential cell-intrinsic factor that controls an iNKT lineage specific gene expression program and epigenetic landscape in a demethylase activity dependent manner. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
9 Samples
Download data: CEL
Series
Accession:
GSE84015
ID:
200084015
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