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Links from GEO DataSets

Items: 13

1.
Full record GDS5609

Notch ligand delta-like 4 effect on interleukin 10-secreting T helper 1 cells

Analysis of IL-10-secreting and -nonsecreting T helper 1 (Th1) cells stimulated with Notch ligand Delta-like 4. The Notch pathway is a major driver of IL-10 production in Th1 cells. Results provide insight into the molecular basis of Notch-mediated IL-10 induction in Th1 cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 cell type sets
Platform:
GPL1261
Series:
GSE57417
4 Samples
Download data: CEL, CHP
2.

Role of Blimp-1 in programing Th effector cells into IL-10 producers

(Submitter supplied) Gene expression profiling on IL-10-secreting and non-secreting murine Th1 cells, stimulated in the presence or absence of the Notch ligand Delta-like 4 (Dll4), was performed to identify transcription factors co-expressed with IL-10.
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS5609
Platform:
GPL1261
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE57417
ID:
200057417
3.

RNAseq profiling of miR-132/212-deficient CD4+ T cells activated in vitro and in vivo.

(Submitter supplied) Transcriptomic profiling of miR-132/212-deficient and WT CD4 T cells isolated from spleens of L donovani infected mice (d28) to determine the effects of miR-132/212 on CD4 T cell activation in vivo. This was combined by transcriptomic analysis of early stage in vitro activated WT and miR-132/212-deficient CD4 T cells to identify direct miR-132/212 targets in CD4 T cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
25 Samples
Download data: TXT
Series
Accession:
GSE125268
ID:
200125268
4.

Gene expression profiles of mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells

(Submitter supplied) Regulatory T (Treg) cells are required for peripheral tolerance. Recent evidence indicates that Treg cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with T helper differentiation. We demonstrate that expression of the transcription factor Blimp1 defines a population of Treg cells that localize predominantly to mucosal sites and produces IL-10. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6105
6 Samples
Download data: TXT
Series
Accession:
GSE27143
ID:
200027143
5.

Transcriptional profiling of antigen-specific CD8 T cells from wildtype and mutant mice.

(Submitter supplied) To understand CD8 effector T cell differentiation in more detial we have used transcriptional profiling of antigen-specific CD8 T cells deficient in Blimp1, IL-2ra, or both, or Tbet. We reveal a common program of effector differentiation regulated by cytokine signaling and the combined activities of Blimp1 and T-bet, indicating remarkable redundancy and specificity in the control of genes involved in the differentiation of effector T cells.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL9185
16 Samples
Download data: TXT
Series
Accession:
GSE68056
ID:
200068056
6.

Gene array for identifying molecules involved in IL-10 regulation during Th17 polarization

(Submitter supplied) IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta, and associated with Th17 IL-10 production. Both c-Maf and IL-10 induction during Th17 polarization depended on Stat3, but not Stat6 or Stat1, and mechanistically differed from IL-10 regulation by Th2 or IL-27 signals. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
3 Samples
Download data: CEL, CHP
Series
Accession:
GSE15029
ID:
200015029
7.

Expression data from Ctrl and Cko B10 cells in steady state and anti-CD40 stimulstion for 48 h.

(Submitter supplied) Transcriptional repressor Prdm1/Blimp1 is known to play a key role in controlling B ells differentiation and regulating IL-10 production in regulatory T cells. B10 cells is the main IL-10 producing B cells in mouse spleen. We found that B10 cells and IL-10+ B cell levels are increased in Prdm1-deficient mice. Here, we compared the gene expression profiles of B10 cells from Prdm1-deficient mice (Cko) and its control littermate mice (Ctrl) in steady state and stimulated with anti-CD40 antibody for 48 h.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
4 Samples
Download data: CEL, TXT
Series
Accession:
GSE133762
ID:
200133762
8.

Expression data from splenic IL-10 positive and IL-10 negative B cells of C57BL/6

(Submitter supplied) The mechanisms in regulating the development of IL-10 producing B cells are largely unknown. To clarify which transcription factor is critical for regulation of IL-10 producing B cells, we compared the gene expression profile of IL-10 positive B cells and IL-10 negative B cells. Transcriptional repressor Prdm1/Blimp1 is known to play a key role in controlling B ells differentiation. We show a dual role for Blimp-1 in IL-10 expression in IL-10 producing B cells and plasmablasts.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
8 Samples
Download data: CEL, XLSX
Series
Accession:
GSE129260
ID:
200129260
9.

Early T-helper 1 Differentiation Is Marked by A Follicular Helper-like Transition: Differential Roles of STAT4 and T-bet

(Submitter supplied) Follicular helper T (Tfh) cells comprise an important subset of helper T cells; however, their relationship with other helper lineages is incompletely understood. Herein, we show IL-12 acting via signal transducer and activator of transcription 4 (STAT4) induced both Il21 and Bcl6 genes, generating cells with features of both Tfh and Th1 cells. However, STAT4 also induced T-bet. Using ChIP-seq, we defined the genome-wide targets of T-bet and found that it repressed Bcl6 and other markers of Tfh cells, thereby attenuating the nascent Tfh-like phenotype in the late phase of Th1 specification. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11002
9 Samples
Download data: BEDGRAPH
Series
Accession:
GSE33802
ID:
200033802
10.

Autoregulation of Th1-mediated inflammation by twist1

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platforms:
GPL81 GPL8321
10 Samples
Download data: CEL, CHP
Series
Accession:
GSE11556
ID:
200011556
11.

Autoregulation of Th1-mediated inflammation by twist1 2nd part

(Submitter supplied) Gene expression profiling of repeatedly activated compared to recently activated Th1 cells to identify genes that play a role in chronic inflammatory disorders and may qualify as diagnostic or therapeutic targets; Upon activation under appropriate costimulatory conditions, naive T helper (Th) cells differentiate into Th2 or Th17 cells, each characterized by the expression of specific effector cytokines. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL81
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE11534
ID:
200011534
12.

Autoregulation of Th1-mediated inflammation by twist1 1st part

(Submitter supplied) The basic helix-loop-helix transcriptional repressor twist1, as an antagonist of nuclear factor κB (NF-κB)-dependent cytokine expression, is involved in the regulation of inflammation-induced immunopathology. We could show that twist1 is expressed by activated T helper (Th) 1 effector memory cells. Induction of twist1 in Th cells is dependent on NF-κB, nuclear factor of activated T cells (NFAT), and interleukin (IL)-12 signaling via signal transducer and activator of transcription (STAT) 4. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
4 Samples
Download data: CEL, CHP
Series
Accession:
GSE11533
ID:
200011533
13.

Gene expression in LCMV-specific Blimp-1 deficient effector CD8+ T cells compared to wildtype effector CD8+ T cells

(Submitter supplied) Antigen-specific effector CD8+ T cells deficient in Blimp-1 (Prdm1) do not acquire maximal effector functions, evade terminal differentiation, and more rapidly acquire some hallmark properties of memory CD8+ T cells. In this study, we compared the gene expression profiles of wildtype and Prdm1-/- LCMV-specific effector CD8+ T cells to better understand the molecular mechanisms underlying this striking phenotype.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6422
8 Samples
Download data
Series
Accession:
GSE17211
ID:
200017211
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